Natan Straathof

Prof. Natan Straathof

DTU
orcid

Research Focus & Metrics

Academic Career Length

15Years (2012-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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3 March 2016 in Chemical Reviews
Verified
Journal Article
Closed access
DCDario Cambié
Dario Cambié
CBCecilia Bottecchia
Cecilia Bottecchia
NSNatan Straathof
Natan Straathof
VHVolker Hessel
Volker Hessel
TNTimothy Noël
Timothy Noël

23 July 2014 in Chemistry – A European Journal
Verified
Journal Article
Closed access
PDF file
YSYuanhai Su
Yuanhai Su
NSNatan Straathof
Natan Straathof
VHVolker Hessel
Volker Hessel
TNTimothy Noël
Timothy Noël

15 November 2016 in Angewandte Chemie International Edition
Verified
Journal Article
Closed access
PDF file
NSNatan Straathof
Natan Straathof
SCSten E. Cramer
Sten E. Cramer
VHVolker Hessel
Volker Hessel
TNTimothy Noël
Timothy Noël

7 May 2020 in Journal of the American Chemical Society
Verified
Journal Article
Open access
JSJeroen B. I. Sap
Jeroen B. I. Sap
NSNatan Straathof
Natan Straathof
TKThomas Knauber
Thomas Knauber
CMClaudio F. Meyer
Claudio F. Meyer
MMMaurice Médebielle
Maurice Médebielle
VGVéronique Gouverneur
Véronique Gouverneur
Molecular editing such as insertion, deletion and single atom exchange in highly functionalized compounds is an aspira-tional goal for all chemists. Here, we disclose a photoredox protocol for the replacement of a single fluorine atom with hydrogen in a range of electron-deficient trifluoromethylarenes including complex drug molecules. A robustness screening experiment shows that this reductive defluorination tolerates a range of functional groups and heterocycles commonly found in bioactive molecules. Preliminary mechanistic studies allude to a catalytic cycle whereby the excited state of the organophotocatalyst is reductively quenched by the hydrogen atom do-nor, and returned in its original oxidation state by the trifluoromethylarene.

6 April 2014 in ChemSusChem
Verified
Journal Article
Closed access
PDF file
NSNatan Straathof
Natan Straathof
HGHannes P. L. Gemoets
Hannes P. L. Gemoets
XWXiao Wang
Xiao Wang
JSJaap C. Schouten
Jaap C. Schouten
VHVolker Hessel
Volker Hessel
TNTimothy Noël
Timothy Noël

3 December 2015 in Nature Protocols
Verified
Journal Article
Closed access
NSNatan Straathof
Natan Straathof
YSYuanhai Su
Yuanhai Su
VHVolker Hessel
Volker Hessel
TNTimothy Noël
Timothy Noël