Background/Objectives: The use of rehabilitation interventions is critical in addressing health and economic outcomes, including return to work (RTW) facilitation for individuals with disabilities. However, the economic evaluation of these interventions has been found to lack consistency, with limited adherence to reporting standards and little focus on integrated approaches. This scoping review will map the existing evidence on the economic evaluations of rehabilitation interventions and their implications for return to work (RTW) programs. Methods: A systematic search of databases, such as PubMed, Scopus, and Web of Science, to identify studies that provided full economic evaluations of rehabilitation interventions related to RTW. Using the PRISMA-ScR framework, 11 studies were ultimately included. Data extraction included the model type, cost-effectiveness models, adherence to CHEERS reporting guidelines, and implications for RTW. Results: The majority of studies examined medical or psychological interventions, with little representation of vocational or integrated approaches. ICERs differed greatly between studies based on methodologies and healthcare settings. The reporting of heterogeneity, uncertainty analysis, and societal perspectives were some of the gaps identified from adherence to CHEERS guidelines. Conclusions: Economic evaluations show that rehabilitation interventions can be cost-effective for improving RTW outcomes. Future research priorities include interdisciplinary approaches, standardized methodologies, and studies based on LMICs to address global disparities.

People often turn to sweet foods for comfort during times of stress, as energy imbalance is implicated in several neuropsychiatric disorders including post-traumatic stress disorder (PTSD). Although acute sucrose consumption may improve cognitive capabilities, its long-term effectiveness has been debated. Objectives: In a widely used mouse model, we examined the effect of sucrose drinking on conditioned fear-induced freezing (as a model of PTSD), with emphasis on the concentrations and timing of the intervention as well as sex differences. We aimed to develop a low-cost, widely accessible therapeutic option. Methods: A short electric foot shock was used for trauma, and freezing was detected 24 h (mimicking acute stress disorder, ASD) or 14 days (PTSD-like symptoms) later in the trauma context and with trauma cues. Results: First, we confirmed that our trauma increased freezing, independent of previous habituation to sucrose drinking. Next, we confirmed that 16% and 32%, but not 2% sucrose drinking for 24 h (but not 3 h) immediately after trauma, diminished freezing behavior the next day. However, the same intervention did not influence behavior 14 days later. Moreover, we could not find any curative effect of 24 h of 16% sucrose consumption before testing remote fear memory 14 days after trauma. Conclusions: Consuming a high-calorie solution immediately following trauma for 24 h may influence ASD but does not necessarily alter the development of PTSD symptoms. Here, we offer a new perspective on energy regulation in neuropsychiatric disorders.

Background: Posttraumatic stress disorder (PTSD) is a mental illness in which central stress-regulating regions, including locus coeruleus (LC) and paraventricular nucleus of hypothalamus (PVN), play key roles. Clonidine, a central sympatholytic drug, can inhibit LC activity and reduce PTSD-related symptoms, suggesting noradrenergic involvement. Glia-driven immune mechanisms may link LC activity to PVN responses. Since TRPA1 ion channel is implicated in both neuroinflammation and stress adaptation, we aimed to determine whether its presence modulates the function of brain structures contributing to PTSD-related alteration in central stress adaptation. Methods: Foot shock PTSD model was applied to Trpa1 wild-type (WT) and knockout (KO) mice, and outcomes were assessed four weeks later. Immunohistochemistry was used to evaluate tyrosine hydroxylase (TH) levels in the LC and glial activation in the PVN. Behavioral effects of clonidine and circulating corticosterone levels were also examined. Results: Stress increased LC/TH immunoreactivity and PVN glial activation. Trpa1 deletion exaggerated LC/TH responses but reduced PVN astrocyte activation. Clonidine increased freezing and decreased jumping (a hyperarousal marker). KO mice showed enhanced jumping and did not respond to clonidine. Corticosterone levels remained unchanged. Conclusions: TRPA1 may support stress adaptation in PTSD by regulating LC noradrenergic output and PVN neuroinflammation, independently of α₂-adrenergic signaling.

Objective Knee pain is prevalent across all age groups, affecting approximately 25% of adults, with reported prevalence rates ranging from 10% to 60% depending on the underlying etiology. Over the past two decades, the incidence of knee pain has increased by nearly 65%, influenced by various causative factors—proximal, local, and ...