This work presents the development of titanium dioxide (TiO₂) film immobilized on circular glass sheets for photocatalytic degradation of caffeine under ultraviolet C (UVC) irradiation. TiO₂ was synthesized through the ultrasonic-assisted sol–gel method and immobilized on circular glass sheets by the doctor blade technique. Polyvinylpyrrolidone (PVP) was used to mix with the TiO₂ precursor solution to enhance film adhesion on the glass surface. TiO₂ film was mainly composed of anatase phase with a small amount of rutile phase. Caffeine removal was found to increase with increasing irradiation time. Caffeine (20 mg/L) in the synthetic wastewater could not be detected after 3 h of UVC irradiation. The reaction rate of caffeine degradation followed the pseudo-first-order model. The concentrated caffeine solutions required a longer irradiation time for degradation. The used TiO₂-coated glass sheets could be easily separated from the treated wastewater and reusable. The caffeine removal efficiency of TiO₂-coated glass sheets in each cycle maintained a high level (~100%) during fifteen consecutive cycles.