María José Ruiz

Prof. Dr. María José Ruiz

Department of Preventive Medicine and Public Health, University of Valencia, Valencia, Spain
orcid

Research Focus & Metrics

Academic Career Length

34Years (1993-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 March 2007 in Journal of Biochemical and Biophysical Methods
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Journal Article
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Yolanda PicòYolanda Picò
Yolanda Picò
MFMónica Fernández-Franzón
Mónica Fernández-Franzón
María José RuizMaría José Ruiz
María José Ruiz
GFGuillermina Font
Guillermina Font

17 March 2009 in Journal of Agricultural and Food Chemistry
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Journal Article
Closed access
María José RuizMaría José Ruiz
María José Ruiz
MFMónica Fernández-Franzón
Mónica Fernández-Franzón
Yolanda PicòYolanda Picò
Yolanda Picò
JMJordi Mañes
Jordi Mañes
MAM. Asensi
M. Asensi
JEJose M. Estrela
Jose M. Estrela

30 June 2022 in Toxins
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Journal Article
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Veronica ZingalesVeronica Zingales
Veronica Zingales
MTMercedes Taroncher
Mercedes Taroncher
PMPiera Anna Martino
Piera Anna Martino
María José RuizMaría José Ruiz
María José Ruiz
FCFrancesca Caloni
Francesca Caloni
Earth’s climate is undergoing adverse global changes as an unequivocal result of anthropogenic activity. The occurring environmental changes are slowly shaping the balance between plant growth and related fungal diseases. Climate (temperature, available water, and light quality/quantity; as well as extreme drought, desertification, and fluctuations of humid/dry cycles) represents the most important agroecosystem factor influencing the life cycle stages of fungi and their ability to colonize crops, survive, and produce toxins. The ability of mycotoxigenic fungi to respond to Climate Change (CC) may induce a shift in their geographical distribution and in the pattern of mycotoxin occurrence. The present review examines the available evidence on the impact of CC factors on growth and mycotoxin production by the key mycotoxigenic fungi belonging to the genera Aspergillus, Penicillium, and Fusarium, which include several species producing mycotoxins of the greatest concern worldwide: aflatoxins (AFs), ochratoxins, and fumonisins (FUMs).

1 December 2009 in Toxicology in Vitro
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EGEmilia FERRER GARCIA
Emilia FERRER GARCIA
Ana Juan-GarciaAna Juan-Garcia
Ana Juan-Garcia
GFGuillermina Font
Guillermina Font
María José RuizMaría José Ruiz
María José Ruiz

16 November 2017 in Frontiers in Public Health
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Journal Article
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APAlessandra Prosperini
Alessandra Prosperini
HBHouda Berrada
Houda Berrada
María José RuizMaría José Ruiz
María José Ruiz
FCFrancesca Caloni
Francesca Caloni
TCTeresa Coccini
Teresa Coccini
ALAlessandra Lafranconi
Alessandra Lafranconi
Mycotoxin enniatin B (ENN B) is a secondary metabolism product by Fusarium fungi. It is a well-known antibacterial, antihelmintic, antifungal, herbicidal, and insecticidal compound. It has been found as a contaminant in several food commodities, particularly in cereal grains, co-occurring also with other mycotoxins. The primary mechanism of action of ENN B is mainly due to its ionophoric characteristics, but the exact mechanism is still unclear. In the last two decades, it has been a topic of great interest since its potent mammalian cytotoxic activity was demonstrated in several mammalian cell lines. Moreover, the co-exposure in vitro with other mycotoxins enhances its toxic potential through synergic effects, depending on the concentrations tested. Despite its clear cytotoxic effect, European Food Safety Authority stated that acute exposure to ENNs, such as ENN B, does not indicate concern for human health, but a concern might be the chronic exposure. However, given the lack of relevant toxicity data, no firm conclusion could be drawn and a risk assessment was not possible. In fact, very few studies have been carried out in vivo and, in these studies, no adverse effects were observed. So, research on toxicological effects induced by ENN B is still on-going. Recently, some studies are dealing with new advances regarding ENN B. This review summarizes the information on biochemical and biological activity of ENN B, focusing on toxicological aspects and on the latest advances in research on ENN B.

1 January 2018 in Food and Chemical Toxicology
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Journal Article
Closed access
BMBeatriz Mallebrera
Beatriz Mallebrera
APAlessandra Prosperini
Alessandra Prosperini
GFGuillermina Font
Guillermina Font
María José RuizMaría José Ruiz
María José Ruiz