Browsing is a prevalent activity on the World Wide Web, and users usually demonstrate significant expectations for expeditious information retrieval and seamless transactions. This article presents a comprehensive performance evaluation of the most frequently accessed webpages in recent years using Data Envelopment Analysis (DEA) adapted to the context (inverse DEA), comparing their performance under two distinct communication protocols: TCP/IP and QUIC. To assess performance disparities, parametric and non-parametric hypothesis tests are employed to investigate the appropriateness of each website’s communication protocols. We provide data on the inputs, outputs, and efficiency scores for 82 out of the world’s top 100 most-accessed websites, describing how experiments and analyses were conducted. The evaluation yields quantitative metrics pertaining to the technical efficiency of the websites and efficient benchmarks for best practices. Nine websites are considered efficient from the point of view of at least one of the communication protocols. Considering TCP/IP, about 80.5% of all units (66 webpages) need to reduce more than 50% of their page load time to be competitive, while this number is 28.05% (23 webpages), considering QUIC communication protocol. In addition, results suggest that TCP/IP protocol has an unfavorable effect on the overall distribution of inefficiencies.