Water quality is a big concern for the humankind as it is the most important natural resource. Water is polluted by increasing activities of population and the necessity to provide them with goods and services that use water as a vital resource. In this study, surface water samples were collected in the summer and the winter season from Rupsa river, Bangladesh, and pH, electrical conductivity (EC), Cr, Ni, Cu, As, Cd and Pb concentrations were analyzed to assess the metal toxicity, identify the possible sources and determine health risk from metals in water. During the the summer season, the mean concentrations of Cr, Pb, As, Cu, Ni and Cd were measured as 7.20 ± 0.613, 7.09 ± 0.904, 5.45 ± 0.441, 5.36 ± 0.471, 3.85 ± 0.694 and 0.975 ± 0.106 µg/L, respectively, whereas the concentrations were measured as 8.87 ± 0.756, 7.32 ± 0.93, 6.05 ± 0.490, 6.02 ± 0.529, 5.48 ± 0.986 and 1.38 ± 0.151 µg/L, respectively, during the the winter season. Source identification like correlation analysis, Principal component analysis (PCA) and cluster analysis (CA) were applied to identify the source of toxic metals in water. Total heavy metal toxicity load and heavy metal evaluation index values were found to be higher than permissible value except for Cu. According to the ecological risk index classification, 85% of the total samples were found to pose moderate ecological risks, while the rest 15% were found to pose low ecological risks during both seasons. As showed high non-carcinogenic risk on the basis of single element via oral exposure. The hazard index value for oral exposure by male, female and children was found to be 4.17E + 00, 3.67E + 00 and 8.64E + 00, respectively; indicating that non-carcinogenic effects are obvious to occur. The carcinogenic risks of Ni and As due to regular exposure via oral and dermal contact pathways were higher than the standard value (>1.0E-04) which anticipated possible cancer risks to male, female and children in the study area.

Rice is the staple food of Bangladeshi people and is consumed at least twice a day. Thus, the presence of toxic metals in rice grains has become a major public health concern in Bangladesh. The present research was conducted to investigate the concentrations of toxic metals in rice grains and their possible human health risks in the Tangail district of Bangladesh. Toxic metals were measured by using an inductively coupled plasma mass spectrometer (ICP-MS), and the mean concentrations of toxic metals in rice samples were found in order of Cr > Pb > Ni > As > Cu > Cd. The concentrations of Cr, Pb, As, and Cd in the studied rice grain samples exceeded the FAO/WHO standard values for food samples by 100%, whereas the Ni concentrations by 10%. The principal component analysis (PCA) revealed significant anthropogenic contributions of Cr, Ni, As, and Pb concentrations in rice grains. The metal concentrations in rice grain samples showed strong significant correlations by forming primary clusters with each other. The estimated daily intake (EDI) values of Cr, Ni, As, Cd, and Pb from all samples were higher than the maximum tolerable daily intake (MTDI) allowed. The total targeted hazard quotient (TTHQ) values of Cu, Ni, As, Cd, and Pb also exceeded the threshold value of 1.00, indicating a potential non-carcinogenic risk. The estimated target carcinogenic risk of As was higher than the USEPA threshold level 10⁻⁴ (0.0001) indicating increased risk of cancer for adults and children in the study area.

Human immunodeficiency virus (HIV) is one of the leading causes of death worldwide, with African countries being the worst affected by this deadly virus. Curcumin (CUR) is a Curcuma longa-derived polyphenol that has attracted the attention of researchers due to its antimicrobial, anti-inflammatory, antioxidant, immunomodulatory and antiviral effects. CUR also demonstrates anti-HIV effects by acting as a possible inhibitor of gp120 binding, integrase, protease, and topoisomerase II activities, besides also exerting a protective action against HIV-associated diseases. However, its effectiveness is limited due to its poor water solubility, rapid metabolism, and systemic elimination. Nanoformulations have been shown to be useful to enhance curcumin’s bioavailability and its effectiveness as an anti-HIV agent. In this sense, bioactive effects of CUR in HIV infection are carefully reviewed, along with the most effective isolation techniques and type of nanoformulations available.

Antimicrobial resistance among the bacteria present in ready-to-eat foods like vegetable salads is an emerging concern today. The current study was undertaken to investigate the presence of multi-drug resistant extended-spectrum β-lactamase (ESBL) producing E. coli and Salmonella spp. in raw vegetable salads served at hotels and restaurants in Bharatpur. A total of 216 salad samples were collected from three different grades of hotels and restaurants and examined for the presence of E. coli and Salmonella spp. in Microbiology laboratory of Birendra Multiple Campus by conventional microbiological techniques. Out of 216 samples, 66 samples (35.2%) showed the presence of Salmonella spp. whereas E. coli was recovered from 29 (13.4%) samples of which 3 samples harbored E. coli O157: H7. Antibiotic susceptibility testing revealed that 9 (13.6%) Salmonella and 4 (13.8%) E. coli isolates were detected as multi-drug resistant. Total ESBL producers reported were 5 (7.57%) Salmonella and 4 (13.8%) E. coli. The study also assessed a significant association between occurrence of E. coli and Salmonella with different grades of hotels and restaurants, personal hygiene and literacy rate of chefs and with the type of cleaning materials used to wash knives and chopping boards (p < 0.05). The findings suggest an immediate need of attention by the concerned authorities to prevent the emergence and transmission of food-borne pathogens and infections antimicrobial resistance among them.