Vanessa de Andrade Royo

Prof. Dr. Vanessa de Andrade Royo

Biologia Geral, Universidade Estadual de Montes Claros, Montes Claros, Minas Gerais, Brazil
orcid

Research Focus & Metrics

Academic Career Length

23Years (2004-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 January 2005 in Bioorganic & Medicinal Chemistry Letters
Verified
Journal Article
Closed access
VSVanessa A. de Souza
Vanessa A. de Souza
RSRosangela da Silva
Rosangela da Silva
APAna C. Pereira
Ana C. Pereira
Vanessa de Andrade RoyoVanessa de Andrade Royo
Vanessa de Andrade Royo
JSJuliana Saraiva
Juliana Saraiva
MSMárcio Silva
Márcio Silva

1 August 2006 in Zeitschrift für Naturforschung C
Verified
Journal Article
Open access
PDF file
MVMaria Anita L. Vasconcelos
Maria Anita L. Vasconcelos
Vanessa de Andrade RoyoVanessa de Andrade Royo
Vanessa de Andrade Royo
DFDaniele S. Ferreira
Daniele S. Ferreira
Antônio Eduardo Miller CrottiAntônio Eduardo Miller Crotti
Antônio Eduardo Miller Crotti
MSMárcio Silva
Márcio Silva
WCWilson Cunha
Wilson Cunha
The aim of this work was to use in vivo models to evaluate the analgesic and anti-inflammatory activities of ursolic acid (UA) and oleanoic acid (OA), the major compounds isolated as an isomeric mixture from the crude methylene chloride extract of Miconia albicans aerial parts, in an attempt to clarify if these compounds are responsible for the analgesic properties displayed by this plant. Ursolic acid inhibited abdominal constriction in a dose-dependent manner, and the result obtained at a content of 40 mg kg-1 was similar to that produced by administration of acetylsalicylic acid at a content of 100 mg kg-1. Both acids reduced the number of paw licks in the second phase of the formalin test, and both of them displayed a significant anti-inflammatory effect at a content of 40 mg kg-1. It is noteworthy that the administration of the isolated mixture, containing 65% ursolic acid/35% oleanolic acid, did not display significant analgesic and anti-inflammatory activities. On the basis of the obtained results, considering that the mixture of UA and OA was poorly active, it is suggested that other compounds, rather than UA and OA, should be responsible for the evaluated activities in the crude extract, since the crude extract samples displayed good activities.

1 February 2005 in Bioorganic & Medicinal Chemistry Letters
Verified
Journal Article
Closed access
RSRosangela da Silva
Rosangela da Silva
GSGustavo H.B. de Souza
Gustavo H.B. de Souza
ASAdemar A. da Silva
Ademar A. da Silva
VSVanessa A. de Souza
Vanessa A. de Souza
APAna C. Pereira
Ana C. Pereira
JBJairo K. Bastos
Jairo K. Bastos

18 January 2007 in Phytotherapy Research
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Journal Article
Closed access
PDF file
MSMárcio Silva
Márcio Silva
HCH. S. Coímbra
H. S. Coímbra
APA. C. Pereira
A. C. Pereira
VAV. A. Almeida
V. A. Almeida
TLT. C. Lima
T. C. Lima
JBJ. K. Bastos
J. K. Bastos

1 October 2013 in Journal of Ethnopharmacology
Verified
Journal Article
Closed access
FAFelipe Queiroz Alvarenga
Felipe Queiroz Alvarenga
BMBárbara C.F. Mota
Bárbara C.F. Mota
MLMarcel Nani Leite
Marcel Nani Leite
JFJaciara M.S. Fonseca
Jaciara M.S. Fonseca
DODario A. Oliveira
Dario A. Oliveira
RLRosangela S. Laurentiz
Rosangela S. Laurentiz

1 April 2007 in Food and Chemical Toxicology
Verified
Journal Article
Closed access
JMJamile Ferraris Medola
Jamile Ferraris Medola
VCVívian Pedigone Cintra
Vívian Pedigone Cintra
ÉSÉrika Patrı´cia Pesqueira e Silva
Érika Patrı´cia Pesqueira e Silva
Vanessa de Andrade RoyoVanessa de Andrade Royo
Vanessa de Andrade Royo
RSRosângela da Silva
Rosângela da Silva
DTDenise Crispim Tavares
Denise Crispim Tavares