Based on the theoretical framework of systems thinking, this study investigates the mechanism of systems thinking in promoting entrepreneurial persistence among technology entrepreneurs in China’s digital economy development. From a dynamic complex systems perspective, 409 technology entrepreneurs from China, were measured using the systems thinking scale, the psychological ownership scale, the resource bricolage scale, and the entrepreneurial persistence scale. Systems thinking among technology entrepreneurs has been found to enhance entrepreneurial persistence significantly. Psychological ownership of technology entrepreneurs partially mediates the process of systems thinking influencing entrepreneurial persistence. Resource bricolage positively moderates the systems thinking process, influencing entrepreneurial persistence among technology entrepreneurs. This study innovatively introduces systems thinking into the field of technology entrepreneurship, reveals the relationship between systems thinking and entrepreneurial persistence of technology entrepreneurs, and provides theoretical guidance for Chinese technology entrepreneurs to enhance entrepreneurial persistence through systems thinking.