Alan Parker

Prof. Alan Parker

Cardiff University
orcid

Research Focus & Metrics

Academic Career Length

26Years (2001-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

View All Publications
1 February 2008 in Cell
Verified
Journal Article
Closed access
SWSimon Waddington
Simon Waddington
JMJohn H. McVey
John H. McVey
DBDavid Bhella
David Bhella
Alan ParkerAlan Parker
Alan Parker
KBKristeen Barker
Kristeen Barker
Andy BakerAndy Baker
Andy Baker

20 January 2020 in Nature Immunology
Verified
Journal Article
Closed access
PDF file
MCMichael Crowther
Michael Crowther
GDGarry Dolton
Garry Dolton
MLMateusz Legut
Mateusz Legut
MCMarine E. Caillaud
Marine E. Caillaud
ALAngharad Lloyd
Angharad Lloyd
ASAndrew K. Sewell
Andrew K. Sewell

15 October 2006 in Blood
Verified
Journal Article
Closed access
PDF file
Alan ParkerAlan Parker
Alan Parker
SWSimon Waddington
Simon Waddington
CNCampbell G. Nicol
Campbell G. Nicol
DSDmitry M. Shayakhmetov
Dmitry M. Shayakhmetov
SBSuzanne M. Buckley
Suzanne M. Buckley
Andy BakerAndy Baker
Andy Baker
Upon local delivery, adenovirus (Ad) serotype 5 viruses use the coxsackie and Ad receptor (CAR) for cell binding and αv integrins for internalization. When administered systemically, however, their role in liver tropism is limited because CAR-permissive and mutated viruses show similar biodistribution, a finding recently attributed to blood coagulation factor (F) IX or complement protein C4BP binding to the adenovirus fiber and “bridging” to either low-density lipoprotein receptor-related protein or heparan sulfate proteoglycans. Here, we show that hepatocyte transduction in vitro can be enhanced by the vitamin K-dependent factors FX, protein C, and FVII in addition to FIX but not by prothrombin (FII), FXI, and FXII. This phenomenon was not dependent on proteolytic activation or cell signaling activity and for FX was mediated by direct virus-factor binding. Human FX substantially enhanced hepatocyte transduction by CAR-permissive and mutated viruses in an ex vivo liver perfusion model. In vivo, global down-regulation of vitamin K-dependent zymogens by warfarin significantly diminished liver uptake of CAR-deleted Ads; however, this phenomenon was fully rescued by acute infusion of human FX. Our results indicate a common and pivotal role for distinct vitamin K-dependent coagulation factors in mediating hepatocyte transduction by adenoviruses in vitro and in vivo.

11 December 2001 in Journal of the American Chemical Society
Verified
Journal Article
Closed access
DODavid Oupicky
David Oupicky
Alan ParkerAlan Parker
Alan Parker
LSLeonard W. Seymour
Leonard W. Seymour

3 May 2020 in British Journal of Surgery
Verified
Journal Article
Open access
PDF file
NMN. G. Mowbray
N. G. Mowbray
JAJ. Ansell
J. Ansell
JHJ. Horwood
J. Horwood
JCJ. Cornish
J. Cornish
PRP. Rizkallah
P. Rizkallah
JTJ. Torkington
J. Torkington
Background: The COVID-19 global pandemic has resulted in a plethora of guidance and opinion from surgical societies. A controversial area concerns the safety of surgically created smoke and the perceived potential higher risk in laparoscopic surgery.Methods: The limited published evidence was analysed in combination with expert opinion. A review was undertaken of the novel coronavirus with regards to its hazards within surgical smoke and the procedures that could mitigate the potential risks to healthcare staff.Results: Using existing knowledge of surgical smoke, a theoretical risk of virus transmission exists. Best practice should consider the operating room set-up, patient movement and operating theatre equipment when producing a COVID-19 operating protocol. The choice of energy device can affect the smoke produced, and surgeons should manage the pneumoperitoneum meticulously during laparoscopic surgery. Devices to remove surgical smoke, including extractors, filters and non-filter devices, are discussed in detail.Conclusion: There is not enough evidence to quantify the risks of COVID-19 transmission in surgical smoke. However, steps can be undertaken to manage the potential hazards. The advantages of minimally invasive surgery may not need to be sacrificed in the current crisis.

3 December 2021 in Science Advances
Verified
Journal Article
Open access
Alexander BakerAlexander Baker
Alexander Baker
RBRyan J. Boyd
Ryan J. Boyd
DSDaipayan Sarkar
Daipayan Sarkar
ATAlicia Teijeira-Crespo
Alicia Teijeira-Crespo
CCChun Kit Chan
Chun Kit Chan
MBMitesh J. Borad
Mitesh J. Borad
We observe previously unknown interactions between clinically important adenovirus vector capsids, platelet factor 4, and CAR.