André Moreni Lopes

Prof. André Moreni Lopes

Department of Biotechnology, University of São Paulo, Lorena, Brazil
orcid

Research Focus & Metrics

Academic Career Length

20Years (2007-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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8 January 2016 in Applied Microbiology and Biotechnology
Verified
Journal Article
Closed access
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angela jozalaangela jozala
angela jozala
LLLeticia Celia de Lencastre-Novaes
Leticia Celia de Lencastre-Novaes
André Moreni LopesAndré Moreni Lopes
André Moreni Lopes
VSValeria Santos-Ebinuma
Valeria Santos-Ebinuma
PRISCILA MAZZOLAPRISCILA MAZZOLA
PRISCILA MAZZOLA
Marco ChaudMarco Chaud
Marco Chaud

11 December 2007 in Journal of Chemical Technology & Biotechnology
Verified
Journal Article
Open access
PDF file
PRISCILA MAZZOLAPRISCILA MAZZOLA
PRISCILA MAZZOLA
André Moreni LopesAndré Moreni Lopes
André Moreni Lopes
FHFrancislene A Hasmann
Francislene A Hasmann
AJAngela F Jozala
Angela F Jozala
TPThereza Cv Penna
Thereza Cv Penna
Adalberto Pessoa-JrAdalberto Pessoa-Jr
Adalberto Pessoa-Jr
Two‐phase systems can be exploited in separation science for the extraction/purification of desired biomolecules. This article reviews recent experimental work on the use of aqueous two‐phase polymer systems, two‐phase aqueous micellar systems and reversed micellar systems for the extraction/purification of biomolecules. The experimental partitioning behavior of different biomolecules is reviewed and new results with nisin and lipopolysaccharides are presented. An extensive description of each system is presented, based on the biomolecules behavior and the tools employed to improve their extraction and purification. Copyright © 2007 Society of Chemical Industry

17 November 2015 in Biotechnology Progress
Verified
Journal Article
Closed access
LNLetícia Celia de Lencastre Novaes
Letícia Celia de Lencastre Novaes
AJAngela Faustino Jozala
Angela Faustino Jozala
André Moreni LopesAndré Moreni Lopes
André Moreni Lopes
VSValeria Santos-Ebinuma
Valeria Santos-Ebinuma
PRISCILA MAZZOLAPRISCILA MAZZOLA
PRISCILA MAZZOLA
Adalberto Pessoa-JrAdalberto Pessoa-Jr
Adalberto Pessoa-Jr

23 December 2015 in Critical Reviews in Biotechnology
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Journal Article
Closed access
André Moreni LopesAndré Moreni Lopes
André Moreni Lopes
LOLaura de Oliveira-Nascimento
Laura de Oliveira-Nascimento
Artur RibeiroArtur Ribeiro
Artur Ribeiro
CTCarlos Abrunhosa Tairum
Carlos Abrunhosa Tairum
CBCarlos Alexandre Breyer
Carlos Alexandre Breyer
Adalberto Pessoa-JrAdalberto Pessoa-Jr
Adalberto Pessoa-Jr
L-asparaginase (l-asparagine amino hydrolase, E.C.3.5.1.1) is an enzyme clinically accepted as an antitumor agent to treat acute lymphoblastic leukemia and lymphosarcoma. It catalyzes l-asparagine (Asn) hydrolysis to l-aspartate and ammonia, and Asn effective depletion results in cytotoxicity to leukemic cells. Microbial l-asparaginase (ASNase) production has attracted considerable attention owing to its cost effectiveness and eco-friendliness. The focus of this review is to provide a thorough review on microbial ASNase production, with special emphasis to microbial producers, conditions of enzyme production, protein engineering, downstream processes, biochemical characteristics, enzyme stability, bioavailability, toxicity and allergy potential. Some issues are also highlighted that will have to be addressed to achieve better therapeutic results and less side effects of ASNase use in cancer treatment: (a) search for new sources of this enzyme to increase its availability as a drug; (b) production of new ASNases with improved pharmacodynamics, pharmacokinetics and toxicological profiles, and (c) improvement of ASNase production by recombinant microorganisms. In this regard, rational protein engineering, directed mutagenesis, metabolic flux analysis and optimization of purification protocols are expected to play a paramount role in the near future.

1 January 2007
Verified
Journal Article
Closed access
Perola Oliveira MagalhaesPerola Oliveira Magalhaes
Perola Oliveira Magalhaes
André Moreni LopesAndré Moreni Lopes
André Moreni Lopes
PRISCILA MAZZOLAPRISCILA MAZZOLA
PRISCILA MAZZOLA
CRCARLOTA RANGEL-YAGUI
CARLOTA RANGEL-YAGUI
TPThereza C V Penna
Thereza C V Penna
Adalberto Pessoa-JrAdalberto Pessoa-Jr
Adalberto Pessoa-Jr

18 November 2015 in Biomaterials Science
Verified
Journal Article
Closed access
PDF file
JPJuliana de Almeida Pachioni-Vasconcelos
Juliana de Almeida Pachioni-Vasconcelos
André Moreni LopesAndré Moreni Lopes
André Moreni Lopes
AAAlexsandra Apolinário
Alexsandra Apolinário
Johanna Valenzuela OsesJohanna Valenzuela Oses
Johanna Valenzuela Oses
Juliana Souza Ribeiro CostaJuliana Souza Ribeiro Costa
Juliana Souza Ribeiro Costa
CRCARLOTA RANGEL-YAGUI
CARLOTA RANGEL-YAGUI
Nanostructured systems, such as nanoemulsions and polymersomes, are important tools to develop safe and effective therapeutic protein preparations.