We introduce a model-based image reconstruction framework with a convolution neural network (CNN) based regularization prior. The proposed formulation provides a systematic approach for deriving deep architectures for inverse problems with the arbitrary structure. Since the forward model is explicitly accounted for, a smaller network with fewer parameters is sufficient to capture the image information compared to direct inversion approaches, thus reducing the demand for training data and training time. Since we rely on end-to-end training with weight sharing across iterations, the CNN weights are customized to the forward model, thus offering improved performance over approaches that rely on pre-trained denoisers. Our experiments show that the decoupling of the number of iterations from the network complexity offered by this approach provides benefits including lower demand for training data, reduced risk of overfitting, and implementations with significantly reduced memory footprint. We propose to enforce data-consistency by using numerical optimization blocks such as conjugate gradients algorithm within the network; this approach offers faster convergence per iteration, compared to methods that rely on proximal gradients steps to enforce data consistency. Our experiments show that the faster convergence translates to improved performance, primarily when the available GPU memory restricts the number of iterations.

Validation is arguably the bottleneck in the diffusion magnetic resonance imaging (MRI) community. This paper evaluates and compares 20 algorithms for recovering the local intra-voxel fiber structure from diffusion MRI data and is based on the results of the “HARDI reconstruction challenge” organized in the context of the “ISBI 2012” conference. Evaluated methods encompass a mixture of classical techniques well known in the literature such as diffusion tensor, Q-Ball and diffusion spectrum imaging, algorithms inspired by the recent theory of compressed sensing and also brand new approaches proposed for the first time at this contest. To quantitatively compare the methods under controlled conditions, two datasets with known ground-truth were synthetically generated and two main criteria were used to evaluate the quality of the reconstructions in every voxel: correct assessment of the number of fiber populations and angular accuracy in their orientation. This comparative study investigates the behavior of every algorithm with varying experimental conditions and highlights strengths and weaknesses of each approach. This information can be useful not only for enhancing current algorithms and develop the next generation of reconstruction methods, but also to assist physicians in the choice of the most adequate technique for their studies.

In this article, we provide a detailed review of recent advances in the recovery of continuous-domain multidimensional signals from their few nonuniform (multichannel) measurements using structured low-rank (SLR) matrix completion formulation. This framework is centered on the fundamental duality between the compactness (e.g., sparsity) of the continuous signal and the rank of a structured matrix, whose entries are functions of the signal. This property enables the reformulation of the signal recovery as an SLR matrix completion problem, which includes performance guarantees. We also review fast algorithms that are comparable in complexity to current compressed sensing (CS) methods, which enable the framework's application to large-scale magnetic resonance (MR) recovery problems. The remarkable flexibility of the formulation can be used to exploit signal properties that are difficult to capture by current sparse and low-rank optimization strategies. We demonstrate the utility of the framework in a wide range of MR imaging (MRI) applications, including highly accelerated imaging, calibration-free acquisition, MR artifact correction, and ungated dynamic MRI.

We introduce a model-based deep learning architecture termed MoDL-MUSSELS for the correction of phase errors in multishot diffusion-weighted echo-planar MR images. The proposed algorithm is a generalization of the existing MUSSELS algorithm with similar performance but significantly reduced computational complexity. In this work, we show that an iterative re-weighted least-squares implementation of MUSSELS alternates between a multichannel filter bank and the enforcement of data consistency. The multichannel filter bank projects the data to the signal subspace, thus exploiting the annihilation relations between shots. Due to the high computational complexity of the self-learned filter bank, we propose replacing it with a convolutional neural network (CNN) whose parameters are learned from exemplary data. The proposed CNN is a hybrid model involving a multichannel CNN in the k-space and another CNN in the image space. The k-space CNN exploits the annihilation relations between the shot images, while the image domain network is used to project the data to an image manifold. The experiments show that the proposed scheme can yield reconstructions that are comparable to state-of-the-art methods while offering several orders of magnitude reduction in run-time.