Our aim was to assess the relationship between gestational diabetes and glucose intolerance regarding maternal serum PAPP-A and free β‐hCG concentrations in first trimester pregnancies. This study was conducted on 278 women between 18–45 years old with singleton pregnancies. The subjects were divided into four groups, according to their 50 and 100 g OGTT results. Group 1 was the Control Group, Group 2 with positive 50 g OGTT results, but negative 100 g, Group 3 had gestational diabetes after testing with 50 g OGTT (≥180 mg/dl) or with 100 g OGTT. Finally Group 4 was made of women with a one single high glucose level after testing with 100 g OGTT. These groups were analysed in terms of OGTT results. In the GDM group, serum PAPP-A concentrations were significantly lower when compared with the Control Group’s (p = 0.015). There was either no significant differences regarding free β‐hCG concentrations among the groups. GDM rate is 21.1%, the patients with GDM had significantly low concentrations of serum PAPP-A but their f β‐hCG concentrations did not change. Our results are supported by several studies. However, we need greater numbered studies for exact results.

The increased use of assisted reproductive technologies (ART) has led to an increase in the frequency of multiple pregnancies. Multiple pregnancies are associated with higher maternal and fetal morbidity compared to singleton pregnancies. Multifetal pregnancy reduction (MFPR) can be performed to reduce these risks. This study aimed to compare the maternal and perinatal outcomes of triplet pregnancies undergoing MFPR with those followed without intervention. This retrospective cohort study was conducted in a tertiary obstetrics and gynecology clinic over 10 years (January 2014–January 2024). All triplet pregnancies received counseling regarding MFPR. Pregnancies reduced from triplets to twins constituted the MFPR group, while those followed without intervention constituted the conservative management group. Demographic data, obstetric history, and pregnancy outcomes were compared using appropriate statistical tests. A total of 187 triplet pregnancies (MFPR, n = 47; conservative management, n = 140) were examined. No significant differences were found between the groups in terms of maternal age, parity, history of miscarriage or preterm birth (P > .05). The gestational age at delivery was higher in the MFPR (35.2 vs 32.2 wk, P = .003). In triplet pregnancies, conservative treatment was an independent risk factor for delivery at <34 weeks (OR 2.4), cesarean delivery (OR 3.4), and need for NICU (OR 10.6) (all P < .05). Neonatal mortality was 5% in the conservative management and not in the MFPR. The MFPR procedure of triplets can significantly prolong gestational age, reduce the need for NICU, and improve perinatal prognosis. Because it provides these benefits without increasing maternal complications, MFPR should be offered as an option to patients and their families in the first trimester.

This study aimed to investigate if the pregnancy associated plasma Protein-A (PAPP-A) multiples of median (MoM) levels could be used as a marker for the early prediction of RDS. The present study was designed with data gathered from 1773 patients who were referred to our institution for first trimester fetal chromosomal anomaly screening. First trimester PAPP-A MoM values and postnatal RDS occurrences in these pregnancies were retrospectively analysed. Of the 1773 neonates that were included in the study, 28 were delivered at or beyond 37 weeks, and 42 were delivered less than 37 weeks of gestation. In the group of neonates at or beyond 37 weeks, the cut-off value for RDS prediction was determined as 1.02. For this cut-off value, sensitivity was 72.41% and specificity was 91.84%. The area under curve (AUC) was determined to be statistically significant (p < .01). In conclusion, it was determined that in neonates that were delivered at or beyond 37 weeks of gestation, RDS occurrence could be predicted at a significant rate by utilising PAPP-A MoM values.

Objective The COVID-19 pandemic was declared a pandemic and a global health emergency by the World Health Organization (WHO) on March 11, 2020. COVID-19 infection is the most common cause of life-threatening acute respiratory tract infection in adults and older people but more mildly in the childhood age group. While the pandemic continues, there is no clear information about the vertical transmission of COVID-19 infection from the mother to the baby. Methods In our study, we aimed to examine vertical virus transmission (breast milk, amniotic fluid, placenta) in pregnant women with COVID-19 infection and to examine the demographic, clinical, and laboratory characteristics of these infants. Our prospective and observational study was conducted in our hospital between March 1, 2020 and July 31, 2021. Results During the study period, a total of 24 infants were included. All infants were admitted to the neonatal intensive care unit for postnatal follow-up. The virus was not detected in breast milk or amniotic fluids by the SARS-COV-2 reverse transcription polymerase chain reaction (RT-PCR) test, and no evidence of vertical transmission was found. Conclusion In our study, no life-threatening complication was found in the babies of mothers infected with COVID-19 at birth. Babies born to mothers with COVID-19 infection did not develop any system findings that required specific treatment.