Journal of Medical Internet Research - International Scientific Journal for Medical Research, Information and Communication on the Internet #Preprint #PeerReviewMe: Warning: This is a unreviewed preprint. Readers are warned that the document has not been peer-reviewed by expert/patient reviewers or an academic editor, may contain misleading claims, and is likely to undergo changes before final publication, if accepted, or may have been rejected/withdrawn. Readers with interest and expertise are encouraged to sign up as peer-reviewer, if the paper is within an open peer-review period. Please cite this preprint only for review purposes or for grant applications and CVs (if you are the author). Background: Vital signs monitoring is a universal tool for the detection of postoperative complications, but unwell patients can be missed in between traditional observation rounds. New remote monitoring technologies promise to convey the benefits of continuous monitoring to patients on general wards. Objective: The aim of this pilot study was to evaluate whether continuous remote vital signs monitoring is a practical and acceptable way of monitoring surgical patients, and to optimise the delivery of a definitive trial. Methods: A prospective, cluster-randomised, parallel-group, unblinded controlled pilot study was performed. Patients admitted to two surgical wards at a large tertiary hospital received either continuous and intermittent vital signs monitoring, or intermittent monitoring alone using an early warning score system. Continuous monitoring was provided by a wireless patch, worn on the patient’s chest, with data transmitted wirelessly every two minutes to a central monitoring station or a mobile device carried by the patient’s nurse. The primary outcome measure was time to administration of antibiotics in sepsis. Secondary outcome measures included length of hospital stay, 30-day readmission rate, mortality and patient acceptability. Results: 226 patients were randomised between January and June 2017. 140 patients were randomised to continuous remote monitoring; 86 patients were randomised to receive intermittent monitoring alone. On average, patients receiving continuous monitoring were administered antibiotics faster after evidence of sepsis (626 minutes, n=22, 95% CI 431.7-820.3 minutes, versus 1012.8 minutes, n=12, 95% CI 425.0-1600.6 minutes), had a shorter average length of hospital stay (13.3 days, 95% CI 11.3-15.3 days, versus 14.6 days, 95% CI 11.5-17.7 days) and were less likely to require readmission within 30 days of discharge (11.4%, 95% CI 6.16%-16.7%, versus 20.9%, 95% CI 12.3%-29.5%). Wide confidence intervals suggest these differences are not statistically significant. Patients found the monitoring device to be acceptable in terms of comfort and perceived an enhanced sense of safety, despite 34% discontinuing the intervention early. Conclusions: Remote continuous vital signs monitoring on surgical wards is practical and acceptable to patients. Large, well-controlled studies in high-risk populations are required to determine if the observed trends translate into a significant benefit for continuous over intermittent monitoring. Clinical Trial: The study was prospectively registered on the ISRCTN registry on 19th December 2016 under registry number ISRCTN60999823; URL: https://doi.org/10.1186/ISRCTN60999823.