There is an ongoing Oropouche Fever (OF) outbreak in Brazil since 2024. There are dengue and chikungunya prediction models available, but none to help discriminate dengue, chikungunya, and OF. Objective: This study aims to develop and validate clinical prediction models for dengue, chikungunya, OF. Methods: This study uses surveillance data from Espirito Santo state / Brazil, from 2023-2025. Epidemiological investigations and biological samples were used to conclude cases as either (a) clinical-epidemiologically confirmed, (b) laboratory confirmed, or (c) discarded. The predictors were all data related to signs, symptoms, and comorbidities available in the notification forms. The analysis was performed using random forest regression models, one for each outcome, in development and validation datasets. Results: A total of 465,280 observations were analyzed, 261,691 dengue cases (56.6%), 18,676 chikungunya cases (4.0%), 12,174 OF cases (2.6%), and 179,115 discarded cases (38.6%). All three models had good discrimination and moderate to good calibration after scaling prediction. The models retained from 26 to 16 predictors each. Leukopenia and vomiting were the most discriminatory predictors for dengue, arthritis, arthralgia, and rash were the most discriminatory for chikungunya, and epidemiological features were the most relevant for OF. The dengue, chikungunya, and OF models had ROC AUC of 0.726, 0.851, and 0.896 in the validation set, respectively. Conclusion: This research identified predictors most discriminative between dengue, chikungunya, and OF. We developed and validated predictive models, one for each condition, with moderate to very good performance available at https://pedrobrasil.shinyapps.io/INDWELL/. One may use them in diagnostic work-up and arbovirus surveillance.

Wound treatment represents a significant clinical challenge, requiring strategies that combine traditional approaches and technological innovations. The article analyzes advances in vacuum dressings, biopolymers and nanotechnology-based materials, promoting faster and more effective healing. The research used an integrative literature review with databases such as PubMed, Scopus and ScienceDirect, covering publications between 2019 and 2024. The results highlight significant advances in the use of vacuum dressings, biopolymers and nanotechnology-based materials, promoting faster and more effective healing. Despite this, challenges remain, such as personalizing treatments and adapting biopolymers to different needs. The combination of traditional methods and emerging technologies has the potential to optimize care, accelerate tissue regeneration and improve patients' quality of life. The study concludes that integrated and multidisciplinary approaches, combined with new technological developments, are essential to overcome the barriers in the treatment of complex wounds.