Computer-assisted clinical coding (CAC) based on automated coding algorithms has been expected to improve the International Classification of Disease, tenth version (ICD-10) coding quality and productivity, whereas studies oriented to primary diagnosis auto-coding are limited in the Chinese context. This study aims at developing a machine learning (ML) model for automated primary diagnosis ICD-10 coding. A total of 71,709 admissions in Fuwai hospital were included to carry out this study, corresponding to 168 primary diagnosis ICD-10 codes. Based on clinical implications, two feature engineering methods were used to process discharge diagnosis and procedure texts into sequential features and sequential grouping features respectively by which two kinds of models were built and compared. One baseline model using one-hot encoding features was considered. Light Gradient Boosting Machine (LightGBM) was adopted as the classifier, and grid search and cross-validation were used to select the optimal hyperparameters. SHapley Additive exPlanations (SHAP) values were applied to give the interpretability of models. Our best prediction model was developed based on sequential grouping features. It showed good performance in the test phase with accuracy and macro-averaged F1 (Macro-F1) of 95.2% and 88.3% respectively. The comparison of the models demonstrated the effectiveness of the sequential information and the grouping strategy in boosting model performance (P-value < 0.01). Subgroup analysis of the best model on each individual code manifested that 91.1% of the codes achieved the F1 over 70.0%. Our model has been demonstrated its effectiveness for automated primary diagnosis coding in the Chinese context and its results are interpretable. Hence, it has the potential to assist clinical coders to improve coding efficiency and quality in Chinese inpatient settings.

Background: Secondary hypertension is a kind of hypertension with a definite etiology and may be cured. Patients with suspected secondary hypertension can benefit from timely detection and treatment and, conversely, will have a higher risk of morbidity and mortality than those with primary hypertension. Objective: The aim of this study was to develop and validate machine learning (ML) prediction models of common etiologies in patients with suspected secondary hypertension. Methods: The analyzed data set was retrospectively extracted from electronic medical records of patients discharged from Fuwai Hospital between January 1, 2016, and June 30, 2019. A total of 7532 unique patients were included and divided into 2 data sets by time: 6302 patients in 2016-2018 as the training data set for model building and 1230 patients in 2019 as the validation data set for further evaluation. Extreme Gradient Boosting (XGBoost) was adopted to develop 5 models to predict 4 etiologies of secondary hypertension and occurrence of any of them (named as composite outcome), including renovascular hypertension (RVH), primary aldosteronism (PA), thyroid dysfunction, and aortic stenosis. Both univariate logistic analysis and Gini Impurity were used for feature selection. Grid search and 10-fold cross-validation were used to select the optimal hyperparameters for each model. Results: Validation of the composite outcome prediction model showed good performance with an area under the receiver-operating characteristic curve (AUC) of 0.924 in the validation data set, while the 4 prediction models of RVH, PA, thyroid dysfunction, and aortic stenosis achieved AUC of 0.938, 0.965, 0.959, and 0.946, respectively, in the validation data set. A total of 79 clinical indicators were identified in all and finally used in our prediction models. The result of subgroup analysis on the composite outcome prediction model demonstrated high discrimination with AUCs all higher than 0.890 among all age groups of adults. Conclusions: The ML prediction models in this study showed good performance in detecting 4 etiologies of patients with suspected secondary hypertension; thus, they may potentially facilitate clinical diagnosis decision making of secondary hypertension in an intelligent way.

Automated ICD coding via machine learning that focuses on some specific diseases has been a hot topic. As one of the leading causes of death, coronary heart diseases (CHD) have seldom been specifically studied by related research, probably due to lack of data concretely targeting at the diseases. Based on Fuwai-CHD and MIMIC-III-CHD, which are a private dataset from Fuwai Hospital and the CHD-related subset of a public dataset named MIMIC-III respectively, this study aimed at automated CHD coding by a deep learning method, which mainly consists of three modules. The first is a B ERT variant module responsible for encoding clinical text. In the module, we fine-tuned BERT variants with masked language model on clinical text, and proposed a truncation method to tackle the problem that BERT variants generally cannot handle sequences containing more than 512 tokens. The second is a word2vec module for encoding code titles and the third is a label-attention module for integrating the embeddings of clinical text and code titles. In short, we named the method BW_att. We compared BW_att against some widely studied baselines, and found that BW_att performed best in most of the coding missions. Specifically, BW_att reached a Macro-F1 of 96.2% and a Macro-AUC of 98.9% for the top-100 most frequent codes in Fuwai-CHD, which covered 89.2% of the total code occurrences. When predicting the top-50 most frequent codes in MIMIC-III-CHD, BW_att reached a Macro-F1 of 40.5% and a Macro-AUC of 66.1%. Moreover, BW_att was capable of locating informative tokens from clinical text for predicting the target codes. In summary, BW_att can not only suggest CHD codes accurately, but also possess robust interpretability, hence has great potential in facilitating CHD coding in practice.

BACKGROUND Blood transfusion was related to postoperative adverse events and increased medical costs in patients underwent cardiovascular surgery. Predicting transfusion risk or major bleeding risk will help reduce transfusion. Machine learning (ML) methods show good performance at predicting risk, but transfusion risk prediction based on ML models among Chinese population were unavailable. OBJECTIVE To establish and validate prediction models using ML methods for perioperative transfusion risk of patients undergoing cardiovascular surgery in the Chinese population. METHODS Analysis was performed using electronic medical records from patients underwent cardiovascular surgery in Fuwai hospital between January 1, 2016 and June 30, 2019. Based on the 66402 unique patients, a retrospective cohort (N=61892) and a prospective cohort (N=4510) were formed for model derivation and validation. Four ML algorithms including eXtreme Gradient Boosting (XGBoost), random forest, naive Bayes, logistic regression with least absolute shrinkage and selection operator were adopted using 10-folds cross-validation to build prediction models of perioperative blood, red blood cell, plasma and platelet transfusion. According to the model evaluation in the validation cohort, the optimal perioperative blood transfusion prediction model was selected to compare with the Association of Cardiothoracic Anaesthetists perioperative risk of blood transfusion score (the ACTA-PORT score) established in previous research. RESULTS Among ML models, the XGBoost(area under the receiver-operating characteristic curve[AUC]:0.823; 95% confidence interval[CI]: 0.810 to 0.836) outperformed other models for perioperative blood transfusion and showed better prediction ability than ACTA-PORT score (AUC:0.690; 95% CI: 0.673 to 0.707; P<.001) in the validation cohort. While ML prediction models for perioperative red blood cell transfusion, plasma transfusion and platelet transfusion, achieving good model performance as AUC levels were 0.836(95% CI: 0.823 to 0.849), 0.766(95% CI: 0.745 to 0.787) and 0.948(95% CI: 0.937 to 0.959) respectively. CONCLUSIONS The study retrospectively developed and prospectively validated discriminative perioperative transfusion prediction models, which may promote the early warning and intervention against perioperative transfusion, and benefit patient blood management.

BACKGROUND Secondary hypertension is a kind of hypertension with a definite etiology and may be cured. Patients with suspected secondary hypertension can benefit from timely detection and treatment and, conversely, will have a higher risk of morbidity and mortality than those with primary hypertension. OBJECTIVE The aim of this study was to develop and validate machine learning (ML) prediction models of common etiologies in patients with suspected secondary hypertension. METHODS The analyzed data set was retrospectively extracted from electronic medical records of patients discharged from Fuwai Hospital between January 1, 2016, and June 30, 2019. A total of 7532 unique patients were included and divided into 2 data sets by time: 6302 patients in 2016-2018 as the training data set for model building and 1230 patients in 2019 as the validation data set for further evaluation. Extreme Gradient Boosting (XGBoost) was adopted to develop 5 models to predict 4 etiologies of secondary hypertension and occurrence of any of them (named as composite outcome), including renovascular hypertension (RVH), primary aldosteronism (PA), thyroid dysfunction, and aortic stenosis. Both univariate logistic analysis and Gini Impurity were used for feature selection. Grid search and 10-fold cross-validation were used to select the optimal hyperparameters for each model. RESULTS Validation of the composite outcome prediction model showed good performance with an area under the receiver-operating characteristic curve (AUC) of 0.924 in the validation data set, while the 4 prediction models of RVH, PA, thyroid dysfunction, and aortic stenosis achieved AUC of 0.938, 0.965, 0.959, and 0.946, respectively, in the validation data set. A total of 79 clinical indicators were identified in all and finally used in our prediction models. The result of subgroup analysis on the composite outcome prediction model demonstrated high discrimination with AUCs all higher than 0.890 among all age groups of adults. CONCLUSIONS The ML prediction models in this study showed good performance in detecting 4 etiologies of patients with suspected secondary hypertension; thus, they may potentially facilitate clinical diagnosis decision making of secondary hypertension in an intelligent way.