Recent developments in AI have provided assisting tools to support pathologists’ diagnoses. However, it remains challenging to incorporate such tools into pathologists’ practice; one main concern is AI’s insufficient workflow integration with medical decisions. We observed pathologists’ examination and discovered that the main hindering factor to integrate AI is its incompatibility with pathologists’ workflow. To bridge the gap between pathologists and AI, we developed a human-AI collaborative diagnosis tool— xPath —that shares a similar examination process to that of pathologists, which can improve AI’s integration into their routine examination. The viability of xPath is confirmed by a technical evaluation and work sessions with 12 medical professionals in pathology. This work identifies and addresses the challenge of incorporating AI models into pathology, which can offer first-hand knowledge about how HCI researchers can work with medical professionals side-by-side to bring technological advances to medical tasks towards practical applications.

Graph convolutional networks (GCNs) have been introduced to effectively process non-Euclidean graph data. However, GCNs incur large amounts of irregularity in computation and memory access, which prevents efficient use of traditional neural network accelerators. Moreover, existing dedicated GCN accelerators demand high memory volumes and are difficult to implement onto resource limited edge devices. In this work, we propose LW-GCN, a lightweight FPGA-based accelerator with a software-hardware co-designed process to tackle irregularity in computation and memory access in GCN inference. LW-GCN decomposes the main GCN operations into Sparse Matrix-Matrix Multiplication (SpMM) and Matrix-Matrix Multiplication (MM). We propose a novel compression format to balance workload across PEs and prevent data hazards. Moreover, we apply data quantization and workload tiling, and map both SpMM and MM of GCN inference onto a uniform architecture on resource limited hardware. Evaluation on GCN and GraphSAGE are performed on Xilinx Kintex-7 FPGA with three popular datasets. Compared to existing CPU, GPU, and state-of-the-art FPGA-based accelerator, LW-GCN reduces latency by up to 60×, 12×, and 1.7× and increases power efficiency by up to 912×, 511×, and 3.87×, respectively. Furthermore, compared with NVIDIA’s latest edge GPU Jetson Xavier NX, LW-GCN achieves speedup and energy savings of 32× and 84×, respectively.

Recent developments in AI have provided assisting tools to support pathologists' diagnoses. However, it remains challenging to incorporate such tools into pathologists' practice; one main concern is AI's insufficient workflow integration with medical decisions. We observed pathologists' examination and discovered that the main hindering factor to integrate AI is its incompatibility with pathologists' workflow. To bridge the gap between pathologists and AI, we developed a human-AI collaborative diagnosis tool -- xPath -- that shares a similar examination process to that of pathologists, which can improve AI's integration into their routine examination. The viability of xPath is confirmed by a technical evaluation and work sessions with twelve medical professionals in pathology. This work identifies and addresses the challenge of incorporating AI models into pathology, which can offer first-hand knowledge about how HCI researchers can work with medical professionals side-by-side to bring technological advances to medical tasks towards practical applications.

Table S1 shows the nitrified proteins identified by mass spectrometry. Figure S1 shows the cytotoxicity assay of OA in HepG2, PLC and SMMC7721 cell lines.