Indicators of the blood coagulation system (thrombin time, prothrombin time, activated partial thromboplastin time - aPTT) were studied on 42 pregnant cows at 60-75, 135-150 and 210-230 days of pregnancy, divided according to the principle of analogues into three groups: physiological course, fetal growth restriction syndrome without late toxicosis of pregnancy, fetal growth restriction syndrome complicated by gestosis. Pregnancy was diagnosed using transrectal and ultrasound examinations. Fetal growth restriction syndrome was diagnosed at 60-75 days of pregnancy using an ultrasound scanner with a linear sensor with a frequency of 7.5 MHz. Late toxicosis of pregnant animals was diagnosed at 210-230 days of pregnancy by the presence of hypertension, proteinuria and edema. Blood samples were taken from the animals included in the experiment to determine the platelet content, thrombin and prothrombin time and aPTT. It has been established that platelet content is an informative indicator for predicting gestosis in the first five months of pregnancy with a sensitivity of 80.0% and specificity of 87.5%. The sensitivity of thrombin time at 60-150 days of pregnancy is 77.8%, specificity - 90.0%, prothrombin time - 70.0 and 88.9%, aPTT at 135-150 days of pregnancy - 77.8 and 85.7%, respectively. Prognostic markers for early diagnosis of late toxicosis in pregnant animals, determined at 2 months of pregnancy are: platelet level - 451.2 x 10⁹/L and higher; thrombin time – 87.3 seconds and below; prothrombin time – 35.1 seconds and below. Indicators for early diagnosis of gestosis, determined at 5 months of pregnancy, are: platelet level - 437.5 x 10⁹/L and higher; thrombin time – 78.6 seconds and below; prothrombin time – 30.3 seconds and below; aPTT – 41.8 sec and below.

The article presents the results of morphological, biochemical and immunological studies of the blood of cows using biologically active drugs. A double administration of aminoseleferon-b 45 and 15 days before calving at a dose of 5 ml with a 24-hour interval helps reduce the processes of lipid and protein peroxidation, the phenomena of endogenous intoxication with a simultaneous increase in humoral and cellular defense, activation of the antioxidant system. This is manifested by a decrease in the incidence of uterine subinvolution – by 1.3-1.6 times and postpartum endometritis - by 1.6-2.0 times.

The article presents the results of the efficacy of using the drug antimetrimast for the prevention of postpartum endometritis in cows. Administration of antimetrimast on three occasions, starting on the first day after calving, with a 24-hour interval at a dose of 10 ml/animal, provides a 3.3-fold decrease in the incidence of postpartum endometritis in cows, a 2.0-fold increase in prophylactic efficacy, and an increase by 42.7% in the number of fertilized animals. The application of antimetrimast for prophylactic purposes helps reduce the inflammatory reaction in the uterus and activate the humoral and cellular elements of the general nonspecific resistance of bovine organism.

This article presents the data of a study on clinical and laboratory indicators in pregnant cows with various gestation course, indicating the hypoxia development. It has been established that hypoxic state in cows is most pronounced at the final stages of gestation (7-9 months), characterized by a decrease in erythrocyte hemoglobin saturation by 16.8-18.8%, a decrease in the number of osmotic-resistant forms by 1.8-8.0% and a decrease in the diameter of the middle uterine arteries by 12.4-19.9%, with an increase in the erythrocyte count by 7.2%, a decrease in the relative expression level of HIF-1α genes by 1.3-22.2 times and a decrease in blood pressure by 17.9-27.5%. The identified differences in clinical, ultrasound and laboratory indicators manifest the development of intrauterine fetal hypoxia at the final stages of gestation, especially in cows with complicated gestation.