The article presents the results of morphological, biochemical and immunological studies of the blood of cows using biologically active drugs. A double administration of aminoseleferon-b 45 and 15 days before calving at a dose of 5 ml with a 24-hour interval helps reduce the processes of lipid and protein peroxidation, the phenomena of endogenous intoxication with a simultaneous increase in humoral and cellular defense, activation of the antioxidant system. This is manifested by a decrease in the incidence of uterine subinvolution – by 1.3-1.6 times and postpartum endometritis - by 1.6-2.0 times.

The article presents the results of the efficacy of using the drug antimetrimast for the prevention of postpartum endometritis in cows. Administration of antimetrimast on three occasions, starting on the first day after calving, with a 24-hour interval at a dose of 10 ml/animal, provides a 3.3-fold decrease in the incidence of postpartum endometritis in cows, a 2.0-fold increase in prophylactic efficacy, and an increase by 42.7% in the number of fertilized animals. The application of antimetrimast for prophylactic purposes helps reduce the inflammatory reaction in the uterus and activate the humoral and cellular elements of the general nonspecific resistance of bovine organism.

The disease of cows with clinically pronounced catarrhal mastitis is acompanied by an intensification of the pro-cesses of lipid peroxidation and a high level of endogenous intoxication. Etiotropic therapy using the drug Synulox LC contributed to an increase in the activity of the antioxidant defense system, a decrease in the level of oxidative stress and endogenous intoxication. The most pronounced changes in the pro- and antioxidant status were noted when the antimi-crobial drug Sinulox LC and the drug “AMSF” were used together. The additional inclusion of the drug “AMSF” in the treatment regimen provided a decrease in the content of malondialdehyde in the blood by 36.3%, medium-weight molecules – by 34.2% (Р<0,0001), medium molecular peptides – by 37.4% (Р<0.0001) and endogenous intoxication index – by 27.7% (Р<0.01), an increase in vitamin А concentration – by 37.4% (Р<0.005), vitamin Е – by 27.9% (Р<0,005) and vitamin С – by 38.0% (Р<0.05), catalase activity – by 42.9% (Р<0.01) and glutathione peroxidase activity – by 37.4% (Р<0.01.) This was clinically confirmed by an increase in therapeutic efficacy.

The article presents the material on studying the morphobiochemical blood status of cows in the complex therapy of chronic endometritis. It has been established that the use of general stimulant (biostimulgin subcutaneously with a 48-hour interval at a dose of 25.0 ml/animal), symptomatic (uteroton three times with a 24-hour interval at a dose of 10.0 ml/animal) drugs and a new antimicrobial drug (intrauterine 1-2 times with a 24-hour interval at a dose of 20.0 ml/animal) is accompanied by the normalization of inflammatory processes in the reproductive organs, lipid metabolism, liver function, activation of the cellular and humoral link of nonspecific resistance of the organism, the antioxidant system, a decrease in the intensity of lipid peroxidation processes, predominance of anti-inflammatory processes over pro-inflammatory ones.