Prof. Christophe Drouet
CIRIMAT UMR 5085-CNRS, UT, INPT, UPS, ENSIACET, 4 allée Emile Monso, CS 44362, 31030 Toulouse, France
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Academic Career Length
28Years (1999-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
View All Publications2 April 2009 in Osteoporosis International
Journal Article
CRChristian Rey
Christian ReyCCChristèle Combes
Christèle CombesChristophe DrouetMGM. J. Glimcher
M. J. Glimcher1 March 2007 in Materials Science and Engineering: C
Journal Article
CRC. Rey
C. Rey
CCChristèle Combes
Christèle CombesChristophe DrouetHSH. Sfihi
H. Sfihi
ABA. Barroug
A. Barroug
11 June 2019 in Scientific Reports
Journal Article
SEStanislas Von Euw
Stanislas Von EuwYWYan Wang
Yan Wang
GLGuillaume Laurent
Guillaume LaurentChristophe DrouetFBFlorence Babonneau
Florence BabonneauTAThierry Azaïs
Thierry Azaïs +1
Some compositional and structural features of mature bone mineral particles remain unclear. They have been described as calcium-deficient and hydroxyl-deficient carbonated hydroxyapatite particles in which a fraction of the PO43− lattice sites are occupied by HPO42− ions. The time has come to revise this description since it has now been proven that the surface of mature bone mineral particles is not in the form of hydroxyapatite but rather in the form of hydrated amorphous calcium phosphate. Using a combination of dedicated solid-state nuclear magnetic resonance techniques, the hydrogen-bearing species present in bone mineral and especially the HPO42− ions were closely scrutinized. We show that these HPO42− ions are concentrated at the surface of bone mineral particles in the so-called amorphous surface layer whose thickness was estimated here to be about 0.8 nm for a 4-nm thick particle. We also show that their molar proportion is much higher than previously estimated since they stand for about half of the overall amount of inorganic phosphate ions that compose bone mineral. As such, the mineral-mineral and mineral-biomolecule interfaces in bone tissue must be driven by metastable hydrated amorphous environments rich in HPO42− ions rather than by stable crystalline environments of hydroxyapatite structure.
29 July 2013 in BioMed Research International
Journal Article
Christophe DrouetCalcium phosphate apatites are inorganic compounds encountered in many different mineralized tissues. Bone mineral, for example, is constituted of nanocrystalline nonstoichiometric apatite, and the production of “analogs” through a variety of methods is frequently reported. In another context, the ability of solid surfaces to favor the nucleation and growth of “bone-like” apatite upon immersion in supersaturated fluids such as SFB is commonly used as one evaluation index of the “bioactivity” of such surfaces. Yet, the compounds or deposits obtained are not always thoroughly characterized, and their apatitic nature is sometimes not firmly assessed by appropriate physicochemical analyses. Of particular importance are the “actual” conditions in which the precipitation takes place. The precipitation of a white solid does not automatically indicate the formation of a “bone-like carbonate apatite layer” as is sometimes too hastily concluded: “all that glitters is not gold.” The identification of an apatite phase should be carefully demonstrated by appropriate characterization, preferably using complementary techniques. This review considers the fundamentals of calcium phosphate apatite characterization discussing several techniques: electron microscopy/EDX, XRD, FTIR/Raman spectroscopies, chemical analyses, and solid state NMR. It also underlines frequent problems that should be kept in mind when making “bone-like apatites.”
1 March 2013 in Progress in Crystal Growth and Characterization of Materials
Journal Article
Jaime Gómez Morales
Michele IafiscoJDJosé Manuel Delgado-López
José Manuel Delgado-LópezSSStéphanie Sarda
Stéphanie Sarda
Christophe Drouet1 September 2014 in Journal of Archaeological Science
Journal Article
AGA. Grunenwald
A. Grunenwald
CKC. Keyser
C. Keyser
ASA.M. Sautereau
A.M. Sautereau
ECE. Crubézy
E. Crubézy
BLB. Ludes
B. Ludes
Christophe DrouetAbout Me
C. Drouet is a CNRS Senior Scientist, leader of the Phosphates, Pharmacotechnics, and Biomaterials group of the CIRIMAT laboratory (2016‒2020) at the University of Toulouse, France.
PhD in Materials Sciences. Major research fields include the physico-chemistry and thermochemistry of natural or synthetic (bio)minerals and their characterization and surface reactivity. Key milestones include 3 years as a Research Associate in Prof. A. Navrotsky’s group at the University of California at Davis (UCDavis), USA, and other stays including in Prof. J. L.G. Fierro’s group at the University of Madrid, Spain.
A special focus in C. Drouet’s research relates to calcium phosphates and related compounds, including biomimetic nanocrystalline apatites analogous to bone minerals, in view of innovative bio-medical applications (bone repair and nanomedicine). He and Prof. C. Rey contributed to the development of the “hydrated layer model” on the surface of apatite nanocrystals, to cold sintering approaches to consolidate metastable calcium phosphates, and developed colloidal apatite-based nanoparticles for nanomedicine. On (bio)material thermodynamics, C. Drouet developed the ThermAP free software to estimate the thermodynamic properties of complex oxides (e.g. substituted apatites).
C. Drouet received two international awards, namely the honorary Racquel Legeros Award in June 2013 and the ISCM Excellence Award in 2016, for his contribution to the field of calcium phosphates research.