A series of nuevamine aza-analogues were prepared in moderate to good yields in two reaction steps. The synthetic strategy involves an isonitrile-based multicomponent reaction, including an aza-Diels–Alder cycloaddition and Pictet–Spengler reaction as postcondensation.

A series of five novel bis-1,5-disubstituted-1H-tetrazoles (bis-1,5-DS-1H-T) were quickly prepared by a catalyst-free Ugi-azide repetitive process from easily accessible starting materials in excellent yields, either at room temperature (88%–95%) or using mild MW-heating conditions (80%–91%). These molecules may have a wide range of applications, such as chelating agents, organocatalysts and luminescent materials, and mainly as bioactive compounds.

Six novel tris-heterocycles 1′-tetrazolylmethyl-spiro[pyrrolidine-3,3′-oxindoles] were synthesized in 39–82% yields in two experimental steps: (i) a one-pot Ugi-azide/Pictet–Spengler process coupled to (ii) a one-pot oxidative spiro-rearrangement. The synthesized polyheterocycles could be used for further in vitro studies because they contain moieties present in various anticancer bioactive molecules and drugs.

The synthesis of novel and complex molecules of tetrakis-tetrazole was done via a Ugi-azide repetitive reaction from easily accessible starting materials in good yields. The use of orthogonal bifunctional reagents in isocyanide-based multicomponent reactions (IMCR) allowed the synthesis of structurally complex molecules in one pot manner. The molecules herein synthesized could have applications such as use as chelating agents and organocatalysts.

A serie of 2-tetrazolylmethyl-2,3,4,9-tetrahydro-1H-β-carbolines were synthesized via a one pot Ugi-azide/Pictet–Spengler process under mild ultrasound-assisted conditions. The products containing two privileged heterocyclic frameworks: 1,5-disubstituted-1H-tetrazole and tetrahydro-β-carboline, which are present in a variety of bioactive compounds and commercial drugs.

This paper presents a system for the measurement of chlorides in drinking and wastewater, based on an electrochemical process using a selective electrode as a transducer, which was developed by this group. The measurement for the concentration is carried out by introducing the implemented electrode (considered as reference) in the sample that will be analyzed; then a current is passed producing a potential difference in the system. Different aqueous solutions of sodium chloride (NaCl) were used, ranging between 35 and 3546 µg of chloride ions (Cl⁻). As a data acquisition and monitoring system for the analysis, an ATmega 328P microcontroller was used as the main capture element for subsequent interpretation through graphics. The experimental results show that it was possible to detect a potential difference in the electrochemical measurement system that corresponded to 35 µg of chloride ions (Cl⁻), making clear the detection process and the selectivity of chloride ions. It is important to mention that with this measurement system and the applied methodology, results are obtained in real time using a small sample volume and without generate ng extra liquid waste, compared to the application of the traditional analytical titrimetric method. Finally, this chloride measurement system is inexpensive and can be used in drinking and wastewater measurements.