Leukemia is a cancer of blood cells in the bone marrow that affects both children and adolescents. The rapid growth of unusual lymphocyte cells leads to bone marrow failure, which may slow down the production of new blood cells, and hence increases patient morbidity and mortality. Age is a crucial clinical factor in leukemia diagnosis, since if leukemia is diagnosed in the early stages, it is highly curable. Incidence is increasing globally, as around 412,000 people worldwide are likely to be diagnosed with some type of leukemia, of which acute lymphoblastic leukemia accounts for approximately 12% of all leukemia cases worldwide. Thus, the reliable and accurate detection of normal and malignant cells is of major interest. Automatic detection with computer-aided diagnosis (CAD) models can assist medics, and can be beneficial for the early detection of leukemia. In this paper, a single center study, we aimed to build an aggregated deep learning model for Leukemic B-lymphoblast classification. To make a reliable and accurate deep learner, data augmentation techniques were applied to tackle the limited dataset size, and a transfer learning strategy was employed to accelerate the learning process, and further improve the performance of the proposed network. The results show that our proposed approach was able to fuse features extracted from the best deep learning models, and outperformed individual networks with a test accuracy of 96.58% in Leukemic B-lymphoblast diagnosis.

Artificial intelligence (AI)-powered chatbots are rapidly supplanting human-derived scholarly work in the fast-paced digital age. This necessitates a re-evaluation of our traditional research and publication ethics, which is the focus of this article. We explore the ethical issues that arise when AI chatbots are employed in research and publication. We critically examine the attribution of academic work, strategies for preventing plagiarism, the trustworthiness of AI-generated content, and the integration of empathy into these systems. Current approaches to ethical education, in our opinion, fall short of appropriately addressing these problems. We propose comprehensive initiatives to tackle these emerging ethical concerns. This review also examines the limitations of current chatbot detectors, underscoring the necessity for more sophisticated technology to safeguard academic integrity. The incorporation of AI and chatbots into the research environment is set to transform the way we approach scholarly inquiries. However, our study emphasizes the importance of employing these tools ethically within research and academia. As we move forward, it is of the utmost importance to concentrate on creating robust, flexible strategies and establishing comprehensive regulations that effectively align these potential technological developments with stringent ethical standards. We believe that this is an essential measure to ensure that the advancement of AI chatbots significantly augments the value of scholarly research activities, including publications, rather than introducing potential ethical quandaries.

Journal of Animal Science and Technology (JAST) is a peer-reviewed, open access journal publishing original research, review articles and notes in all fields of animal science. Topics covered by the journal include: genetics and breeding, physiology, nutrition of monogastric animals, nutrition of ruminants, animal products (milk, meat, eggs and their by-products) and their processing, grasslands and roughages, livestock environment, animal biotechnology, animal behavior and welfare.

Introduction: Preterm birth is a leading cause of infant mortality and morbidity. Despite the improvement in the overall mortality in premature infants, the intact survival of these infants remains a significant challenge. Screening the physical growth of infants is fundamental to potentially reducing the escalation of this disorder. Recently, machine learning models have been used to predict the growth restrictions of infants; however, they frequently rely on conventional risk factors and cross-sectional data and do not leverage the longitudinal database associated with medical data from laboratory tests.Methods: This study aimed to present an automated interpretable ML-based approach for the prediction and classification of short-term growth outcomes in preterm infants. We prepared four datasets based on weight and length including weight baseline, length baseline, weight follow-up, and length follow-up. The CHA Bundang Medical Center Neonatal Intensive Care Unit dataset was classified using two well-known supervised machine learning algorithms, namely support vector machine (SVM) and logistic regression (LR). A five-fold cross-validation, and several performance measures, including accuracy, precision, recall and F1-score were used to compare classifier performances. We further illustrated the models’ trustworthiness using calibration and cumulative curves. The visualized global interpretations using Shapley additive explanation (SHAP) is provided for analyzing variables’ contribution to final prediction.Results: Based on the experimental results with area under the curve, the discrimination ability of the SVM algorithm was found to better than that of the LR model on three of the four datasets with 81%, 76% and 72% in weight follow-up, length baseline and length follow-up dataset respectively. The LR classifier achieved a better ROC score only on the weight baseline dataset with 83%. The global interpretability results revealed that pregnancy-induced hypertension, gestational age, twin birth, birth weight, antenatal corticosteroid use, premature rupture of membranes, sex, and birth length were consistently ranked as important variables in both the baseline and follow-up datasets.Discussion: The application of machine learning models to the early detection and automated classification of short-term growth outcomes in preterm infants achieved high accuracy and may provide an efficient framework for clinical decision systems enabling more effective monitoring and facilitating timely intervention.

Dementia has a negative impact on global healthcare that has become a serious concern worldwide. The most common cause, Alzheimer's disease, underlies the majority of dementia. The identification and accurate prediction of Alzheimer's disease in its initial stage is most critical, of which has several important practical applications. However, a reliable diagnosis remains a challenging task and requires a combination of methods based on important clinical information. Developing computer-aided diagnosis systems to support early Alzheimer's disease detection is essential for effective treatment planning. In this study, a nationwide cohort dataset, the Korean Brain Aging Study for the Early diagnosis and prediction of Alzheimer's disease is classified by using eight state-of-the-art supervised machine learning algorithms namely Support Vector Machine, Naive Bayes, XGBoost, Decision Tree, Logistic Regression, Random Forest, Bagging and AdaBoost. The best performing model appeared to be the XGBoost classifier yielding an accuracy of 82.09%. Thus, the present research shows that the application of the machine learning model to the KBASE dataset will offer an efficient clinical classification of cognitively normal control individuals, mild cognitive impairment and Alzheimer's disease patients and provides a framework for clinical decision systems.

Kim JK, et al. J Clin Neurol. 2024 Jan;20:e12. https://doi.org/10.3988/jcn.2022.0257