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Denise Mafra

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Principal Investigator and Full Professor at Federal University Fluminense-UFF- Niterói - Rio de Janeiro, Brazil, and Professor of three Postgraduate Programs (Medical Sciences, Cardiovascular Sciences and Nutrition Sciences). Research field is molecular and clinical nutrition, with emphasis on nephrology. Responsible for creating a public outpatient clinic (in 2009) that serves more than 750 non-dialysis patients with chronic kidney disease. Professor in Clinical Nutrition discipline with emphasis on diabetes, cardiovascular and kidney diseases, and supervises trainees at the University Hospital. In the laboratory, we work evaluating the effects of nutrients and bioactive compounds such as cranberry, curcuma, resistant starch, probiotics, Brazil nut, vitamin E, resveratrol, Brazilian propolis, dark chocolate, açai fruit on the gene expression of nuclear transcription factors involved with inflammation such as Nrf2 and NF-kB, also we analyze NLRP3 inflammasome expression, cytokines, DNA damage and oxidative stress markers and gut microbiota composition as well as, uremic toxins produced by the gut microbiota.

Research Keywords & Expertise

Chronic Kidney Disease
Food
Hemodialysis
Inflammation
microbiota

Short Biography

Principal Investigator and Full Professor at Federal University Fluminense-UFF- Niterói - Rio de Janeiro, Brazil, and Professor of three Postgraduate Programs (Medical Sciences, Cardiovascular Sciences and Nutrition Sciences). Research field is molecular and clinical nutrition, with emphasis on nephrology. Responsible for creating a public outpatient clinic (in 2009) that serves more than 750 non-dialysis patients with chronic kidney disease. Professor in Clinical Nutrition discipline with emphasis on diabetes, cardiovascular and kidney diseases, and supervises trainees at the University Hospital. In the laboratory, we work evaluating the effects of nutrients and bioactive compounds such as cranberry, curcuma, resistant starch, probiotics, Brazil nut, vitamin E, resveratrol, Brazilian propolis, dark chocolate, açai fruit on the gene expression of nuclear transcription factors involved with inflammation such as Nrf2 and NF-kB, also we analyze NLRP3 inflammasome expression, cytokines, DNA damage and oxidative stress markers and gut microbiota composition as well as, uremic toxins produced by the gut microbiota.