Ilfir Ramazanov

Prof. Dr. Ilfir Ramazanov

orcid

Research Focus & Metrics

Academic Career Length

30Years (1997-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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20 December 2016 in The Journal of Organic Chemistry
Verified
Journal Article
Closed access
VDVladimir Dyakonov
Vladimir Dyakonov
GKGulnara N. Kadikova
Gulnara N. Kadikova
Lilya U DzhemilevaLilya U Dzhemileva
Lilya U Dzhemileva
GGGuzel F. Gazizullina
Guzel F. Gazizullina
IRIlfir Ramazanov
Ilfir Ramazanov
Lilya U DzhemilevaLilya U Dzhemileva
Lilya U Dzhemileva

10 April 2021 in Cancers
Verified
Journal Article
Open access
PDF file
VDVladimir Dyakonov
Vladimir Dyakonov
AMAlexey A. Makarov
Alexey A. Makarov
Lilya U DzhemilevaLilya U Dzhemileva
Lilya U Dzhemileva
IRIlfir Ramazanov
Ilfir Ramazanov
EMElina Kh. Makarova
Elina Kh. Makarova
Lilya U DzhemilevaLilya U Dzhemileva
Lilya U Dzhemileva
The first Z-stereoselective method was developed for the synthesis of unsaturated acids containing a 1Z,5Z,9Z-triene moiety in 61–64% yields using the new Ti-catalyzed cross-coupling of oxygen-containing and aliphatic 1,2-dienes as the key synthetic step. It was shown for the first time that trienoic acids with non-methylene-interrupted Z-double bonds show moderate cytotoxic activities against tumor cell lines (Jurkat, K562, U937, HL60, HeLa), human embryonic kidney cells (Hek293), normal fibroblasts and human topoisomerase I (hTop1) inhibitory activity in vitro. The synthesized acids efficiently initiate apoptosis of Jurkat tumor cells, with the cell death mechanism being activated by the mitochondrial pathway. A probable mechanism of topoisomerase I inhibition was also hypothesized on the basis of in silico studies resorting to docking. The activation and inhibition of the most versatile intracellular signaling pathways (CREB, JNK, NFkB, p38, ERK1/2, Akt, p70S6K, STAT3 and STAT5 tyrosine kinases) responsible for cell proliferation and for initiation of apoptosis were studied by multiplex assay technology (Luminex xMAP).

9 June 2015 in European Journal of Organic Chemistry
Verified
Journal Article
Closed access
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VDVladimir Dyakonov
Vladimir Dyakonov
GKGulnara N. Kadikova
Gulnara N. Kadikova
DKDmitry I. Kolokol'TSev
Dmitry I. Kolokol'TSev
IRIlfir Ramazanov
Ilfir Ramazanov
Lilya U DzhemilevaLilya U Dzhemileva
Lilya U Dzhemileva

4 May 2009 in Tetrahedron Letters
Verified
Journal Article
Closed access
IRIlfir Ramazanov
Ilfir Ramazanov
AYAlsu V. Yumagulova
Alsu V. Yumagulova
Lilya U DzhemilevaLilya U Dzhemileva
Lilya U Dzhemileva
ONOleg M. Nefedov
Oleg M. Nefedov

1 March 2001 in Russian Chemical Bulletin
Verified
Journal Article
Closed access
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Lilya U DzhemilevaLilya U Dzhemileva
Lilya U Dzhemileva
AIA. G. Ibragimov
A. G. Ibragimov
IRIlfir Ramazanov
Ilfir Ramazanov
MLM. P. Luk'YAnova
M. P. Luk'YAnova
ASA. Z. Sharipova
A. Z. Sharipova

20 July 2017 in Synthesis
Verified
Journal Article
Closed access
PDF file
RKRita Kadikova
Rita Kadikova
IRIlfir Ramazanov
Ilfir Ramazanov
AVAlexey V. Vyatkin
Alexey V. Vyatkin
Lilya U DzhemilevaLilya U Dzhemileva
Lilya U Dzhemileva
The Cp2ZrCl2-catalyzed methylalumination and сycloalumination of 1-alkynyl selenides followed by deuterolysis or hydrolysis affords corresponding (Z)-1-alkenyl selenides in high yields. Alternatively, (E)-1-alkenyl selenides were prepared by the reaction of 1-alkenylaluminums with organic diselenides in a one-pot procedure starting from the corresponding 1-alkynes, which provides a versatile tool for the preparation of stereo-defined unsaturated organic derivatives of selenium.