Diabetes mellitus is a chronic metabolic disorder, being globally one of the most deadly diseases. This disease requires continually monitoring of the body’s glucose levels. There are different types of sensors for measuring glucose, most of them invasive to the patient. Fiber optic sensors have been proven to have advantages compared to conventional sensors and they have great potential for various applications, especially in the biomedical area. Compared to other sensors, they are smaller, easy to handle, mostly non-invasive, thus leading to a lower risk of infection, high precision, well correlated and inexpensive. The objective of this review article is to compare different types of fiber optic sensors made with different experimental techniques applied to biomedicine, especially for glucose sensing. Observations are made on the way of elaboration, as well as the advantages and disadvantages that each one could have in real applications.

Vital signs not only reflect essential functions of the human body but also symptoms of a more serious problem within the anatomy; they are well used for physical monitoring, caloric expenditure, and performance before a possible symptom of a massive failure—a great variety of possibilities that together form a first line of basic diagnosis and follow-up on the health and general condition of a person. This review includes a brief theory about fiber optic sensors’ operation and summarizes many research works carried out with them in which their operation and effectiveness are promoted to register some vital sign(s) as a possibility for their use in the medical, health care, and life support fields. The review presents methods and techniques to improve sensitivity in monitoring vital signs, such as the use of doping agents or coatings for optical fiber (OF) that provide stability and resistance to the external factors from which they must be protected in in vivo situations. It has been observed that most of these sensors work with single-mode optical fibers (SMF) in a spectral range of 1550 nm, while only some work in the visible spectrum (Vis); the vast majority, operate through fiber Bragg gratings (FBG), long-period fiber gratings (LPFG), and interferometers. These sensors have brought great advances to the measurement of vital signs, especially with regard to respiratory rate; however, many express the possibility of monitoring other vital signs through mathematical calculations, algorithms, or auxiliary devices. Their advantages due to miniaturization, immunity to electromagnetic interference, and the absence of a power source makes them truly desirable for everyday use at all times.

Background/Objectives: Differentiating complicated acute appendicitis (CA) and uncomplicated acute appendicitis (UC) is essential to guide clinical management. While CA requires urgent surgical management, UC can be treated with antibiotic therapy in selected cases. However, accurate identification of CA remains a clinical challenge. This study aimed to identify factors associated with CA and to develop a diagnostic severity scale. Methods: In this retrospective study, we included 132 adult patients (>16 years) with a confirmed postsurgical diagnosis of appendicitis, of whom 52 had CA and 80 had UA. Signs, symptoms, comorbidities, laboratory values, and ultrasonographic findings were evaluated to determine predictive factors and construct a diagnostic scale. Results: The factors most significantly associated with CA were elevated plasma concentrations of C-reactive protein (>7.150 mg/dL), fibrinogen (481.5 mg/dL), International Normalized Ratio (INR) (>1.150), and the presence of free fluid periappendicular. The combination of these factors within one scale showed an area under the curve (AUC) of 0.84, with a sensitivity of 78.75% and a specificity of 82.69%. Conclusions: Serum C-reactive protein concentration, fibrinogen, and INR can be employed individually or as part of a scale as important indicators in diagnosing CA.

We propose and demonstrate a tunable and switchable multi-wavelength fiber ring laser configuration based on a Mach–Zehnder interferometer (MZI) filter. The MZI was fabricated using a core-offset splicing technique, with a 2 cm piece of thin-core erbium-doped fiber (TCEDF), with a core diameter of 2.90 µm, coupled in the central region of the MZI between two segments of single-mode fiber (SMF). By applying curvature to the MZI filter, we generated lasing single-, double-, triple-, and quadruple-emission lines with a curvature range from 2.3452 m⁻¹ to 6.0495 m⁻¹. A single-emission lasing line can be tuned from 1556.63 nm to 1564.25 nm with a tuning span of 7.62 nm and an SMSR of 49.80 dB. The laser emission can be switched to quadruple- and triple-emission lasing signals, with SMSR values of 39.96 dB and 36.83 dB, respectively. The dual-narrow emission lasing signal can be tuned from 1564.56 nm to 1561.34 nm, with an SMSR of 40.46 dB. Another lasing dual-emission signal can be tuned from 1585.69 nm to 1576.89 nm, producing an 8.8 nm tuning range, and from 1572.53 nm to 1563.66 nm, producing an 8.87 nm range, with the best SMSR of 42.35 dB.

In this work, we experimentally analyzed and demonstrated the performance of an in-line Mach–Zehnder interferometer in the visible region, with an LED light source. The different waist diameter taper and asymmetric core-offset interferometers proposed used a single-mode fiber (SMF). The visibility achieved was V = 0.14 with an FSR of 23 nm for the taper MZI structure and visibilities of V = 0.3, V = 0.27, and V = 0.34 with FSRs of 23 nm, 17 nm, and 8 nm and separation lengths L of 2.5 cm, 4.0 cm, and 5.0 cm between the core-offset structure, respectively. The experimental investigation of the response to the temperature sensor yielded values from 50 °C to 300 °C; the sensitivity obtained was 3.53 a.u./°C, with ${\mathrm{R}}^2$ of 0.99769 and 1% every 1 °C in the transmission. For a range of 50 °C to 150 °C, 20.3 pm/°C with a ${\mathrm{R}}^2$ of 0.96604 was obtained.

The technique of optical interferometry has many applications in various fields of knowledge, including astronomy, optical metrology, biology, and chemistry. The visible interference pattern of a conventional single mode fiber (SMF-28) tapered and core-offset structured in-line Mach-Zehnder interferometer has been demonstrated. The white source is generated by an LED, with a wavelength range of 400 nm to 650 nm emission. We analyze the performance of the interference emission with a waist length of 1.8 mm to 6 mm and with a waist diameter of 10 µm to 60 µm for the tapered structure. The achieved visibility is V=0.14 with an FSR of 23 nm. The core-offset structure interferometer is analyzed with different displacements in x and y axis and with a separation length L of 2.5 cm, 4.0 cm and 5.0 cm between two core joints. The output interference emission has a visibility of V= 0.3, V=0.27 and V=0.34 with an FSR of 23 nm, 17 nm and 8 nm, respectively. The sensitivity obtained from the temperature sensor is of 3.53 a.u./°C, with R2 of 0.99769. The proposed MZIs are low cost and can be used for implementation of sensing system in the field as the industry and medical applications.