Miloš Nikolić

Dr. Miloš Nikolić

Pharmaceutical Chemistry, University of Kragujevac, Faculty of medical sciences, Kragujevac, Serbia
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Research Focus & Metrics

Academic Career Length

15Years (2012-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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28 April 2023 in Pharmaceuticals
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Journal Article
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Nikola NedeljkovićNikola Nedeljković
Nikola Nedeljković
Vladimir DobričićVladimir Dobričić
Vladimir Dobričić
JBJelena Bošković
Jelena Bošković
MVMarina Vesović
Marina Vesović
JBJovana Bradic
Jovana Bradic
Miloš NikolićMiloš Nikolić
Miloš Nikolić
The aim of the study was a synthesis and investigation of the dose-dependent anti-inflammatory effect of new thiourea derivatives of naproxen with selected aromatic amines and esters of aromatic amino acids. The results of the in vivo study indicate that derivatives of m-anisidine (4) and N-methyl tryptophan methyl ester (7) showed the most potent anti-inflammatory activity four hours after injection of carrageenan, with the percentage of inhibition of 54.01% and 54.12%, respectively. In vitro assays of COX-2 inhibition demonstrated that none of the tested compounds achieved 50% inhibition at concentrations lower than 100 µM. On the other hand, the aromatic amine derivatives (1–5) accomplished significant inhibition of 5-LOX, and the lowest IC50 value was observed for compound 4 (0.30 μM). High anti-edematous activity of compound 4 in the rat paw edema model, together with potent inhibition of 5-LOX, highlight this compound as a promising anti-inflammatory agent.

19 December 2023 in Pharmaceutics
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Nikola NedeljkovićNikola Nedeljković
Nikola Nedeljković
Miloš NikolićMiloš Nikolić
Miloš Nikolić
PČPetar Čanović
Petar Čanović
MZMilan Zaric
Milan Zaric
RZRadica Živković Zarić
Radica Živković Zarić
Vladimir DobričićVladimir Dobričić
Vladimir Dobričić
The objective of this study was to synthesize seven novel thiourea derivatives of naproxen (8–14), examine the anti-inflammatory activity of the newly synthesized compounds, investigate the cytotoxic potential of both sets of synthesized compounds (1–7 and 8–14), and select the most promising anti-inflammatory and antitumor drug candidates. The results of the in vivo anti-inflammatory study clearly showed that compounds 8 and 9 were capable of decreasing paw edema, as evident from a high percentage of inhibition (44.83% and 49.29%, respectively). In addition, the results of in vitro enzyme inhibition assays demonstrated that neither of the newly synthesized compounds reached 50% inhibition of 5-LOX at concentrations lower than 100 µM. In terms of antitumor potential, derivatives 3 and 8 exhibited strong cytotoxic effects on the HeLa cell line, suggesting the involvement of the extrinsic pathway of apoptosis. According to the overall results obtained for both sets of synthesized molecules, derivatives 4 and 8 can be underlined as molecules with the strongest anti-inflammatory activity, while derivatives 3 and 8 are the most promising cytotoxic agents.

1 July 2016 in Journal of Molecular Structure
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Miloš NikolićMiloš Nikolić
Miloš Nikolić
MMMarina Ž. Mijajlović
Marina Ž. Mijajlović
VJVerica V. Jevtić
Verica V. Jevtić
ZRZoran R. Ratković
Zoran R. Ratković
SNSlađana B. Novaković
Slađana B. Novaković
GRGordana P. Radić
Gordana P. Radić

1 January 2017 in Journal of Molecular Structure
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ABAndriana M. Bukonjić
Andriana M. Bukonjić
DTDušan Lj. Tomović
Dušan Lj. Tomović
Miloš NikolićMiloš Nikolić
Miloš Nikolić
MMMarina Ž. Mijajlović
Marina Ž. Mijajlović
VJVerica V. Jevtić
Verica V. Jevtić
GRGordana P. Radić
Gordana P. Radić


1 November 2018 in Transition Metal Chemistry
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APAna Popović
Ana Popović
Miloš NikolićMiloš Nikolić
Miloš Nikolić
MVMarina Vesovic
Marina Vesovic
ZRZoran Ratković
Zoran Ratković
VJVerica Jevtić
Verica Jevtić
IJIvan Jovanović
Ivan Jovanović