Safdar Khan

Dr. Safdar Khan

orcid

Research Focus & Metrics

Academic Career Length

5Years (2022-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 January 2022 in Reproductive Medicine and Biology
Verified
Journal Article
Open access
Safdar KhanSafdar Khan
Safdar Khan
BBBakhtwar Batool
Bakhtwar Batool
HZHira Zubair
Hira Zubair
RBRiffat Bano
Riffat Bano
SAShakil Ahmad
Shakil Ahmad
MSMuhammad Shahab
Muhammad Shahab
Propose: The mechanism that underpins how RFRP‐3 and kisspeptin interacts are not fully understood in higher primates. This study therefore set out to assess RFRP‐3 and kisspeptin expression and their morphological interactions in the breeding, and in the non‐breeding period in monkey hypothalamus.Methods: Eight mature male macaques (Macaca mulatta) in the breeding season (February; n = 4) and non‐breeding season (June; n = 4) were used. To reveal the expression and co‐localization of RFRP‐3 and kisspeptin, double‐labeled immunohistochemistry was performed. Testicular volume, sperm count, and plasma testosterone level were also measured to validate the breeding and non‐breeding paradigms.Results: Testicular volume, plasma testosterone level, and sperm count showed a significant reduction during non‐breeding season. The number of kisspeptin‐positive cells was significantly increased during the breeding season (p < 0.05), whereas more RFRP‐3‐positive cell bodies were seen in the non‐breeding season (p < 0.01). Close contacts of RFRP‐3 fibers with kisspeptin cells showed no significant difference (p > 0.05) across seasons. However, co‐localization of RFRP‐3‐ir cell bodies onto kisspeptin IR cell bodies showed a statistical increase (p < 0.01) in non‐breeding season.Conclusion: In higher primates, RFRP‐3 decreases kisspeptin drives from the same cells to GnRH neurons in an autocrine manner causing suppression of the reproductive axis during the non‐breeding period.


20 March 2025 in Toxicological Research
Verified
Journal Article
Closed access
PDF file
Safdar KhanSafdar Khan
Safdar Khan
Mohammad AttaullahMohammad Attaullah
Mohammad Attaullah
SJSarwat Jahan
Sarwat Jahan
RARahmat Ali
Rahmat Ali
SAShakil Ahmad
Shakil Ahmad

24 February 2026 in Regulatory Toxicology and Pharmacology
Verified
Journal Article
Closed access
Safdar KhanSafdar Khan
Safdar Khan
Mohammad AttaullahMohammad Attaullah
Mohammad Attaullah
MZMuhammad Zubair
Muhammad Zubair
MKMuhammad Kashif Khan
Muhammad Kashif Khan
RARahmat Ali
Rahmat Ali
SJSarwat Jahan
Sarwat Jahan