Sean Cash

Prof. Sean Cash

Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA.
orcid

Research Focus & Metrics

Academic Career Length

25Years (2002-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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13 August 2019 in Frontiers in Plant Science
Verified
Journal Article
Open access
SASelena Ahmed
Selena Ahmed
TGTimothy S. Griffin
Timothy S. Griffin
DKDebra Kraner
Debra Kraner
MSM. Katherine Schaffner
M. Katherine Schaffner
DSDeepak Sharma
Deepak Sharma
Sean CashSean Cash
Sean Cash
Climate change is impacting food and beverage crops around the world with implications for environmental and human well-being. While numerous studies have examined climate change effects on crop yields, relatively few studies have examined effects on crop quality (concentrations of nutrients, minerals, and secondary metabolites). This review article employs a culturally relevant beverage crop, tea (Camelia sinensis), as a lens to examine environmental effects linked to climate change on the directionality of crop quality. Our systematic review identified 86 articles as relevant to the review question. Findings provide evidence that shifts in seasonality, water stress, geography, light factors, altitude, herbivory and microbes, temperature, and soil factors that are linked to climate change can result in both increases and decreases up to 50% in secondary metabolites. A gap was found regarding evidence on the direct effects of carbon dioxide on tea quality, highlighting a critical research area for future study. While this systematic review provides evidence that multiple environmental parameters are impacting tea quality, the directionality and magnitude of these impacts is not clear with contradictory evidence between studies likely due to confounding factors including variation in tea variety, cultivar, specific environmental and agricultural management conditions, and differences in research methods. The environmental factors with the most consistent evidence in this systematic review were seasonality and water stress with 14 out of 18 studies (78%) demonstrating a decrease in concentrations of phenolic compounds or their bioactivity with a seasonal shift from the spring and /or first tea harvest to other seasons and seven out of 10 studies (70%) showing an increase in levels of phenolic compounds or their bioactivity with drought stress. Herbivory and soil fertility were two of the variables that showed the greatest contradictory evidence on tea quality. Both herbivory and soil fertility are variables which farmers have the greatest control over, pointing to the importance of agricultural management for climate mitigation and adaptation. The development of evidence-based management strategies and crop breeding programs for resilient cultivars are called for to mitigate climate impacts on crop quality and overall risk in agricultural and food systems.

2 November 2006 in Canadian Journal of Agricultural Economics/Revue canadienne d'agroeconomie
Verified
Journal Article
Closed access
PDF file
CAChris Arnot
Chris Arnot
PBPeter C. Boxall
Peter C. Boxall
Sean CashSean Cash
Sean Cash

1 September 2023 in Circulation: Cardiovascular Quality and Outcomes
Verified
Journal Article
Closed access
KHKurt Hager
Kurt Hager
MDMengxi Du
Mengxi Du
ZLZhongyu Li
Zhongyu Li
DMDariush Mozaffarian
Dariush Mozaffarian
KCKenneth Chui
Kenneth Chui
FZFang Fang Zhang
Fang Fang Zhang
BACKGROUND: Produce prescriptions may improve cardiometabolic health by increasing fruit and vegetable (F&V) consumption and food insecurity yet impacts on clinical outcomes and health status have not been evaluated in large, multisite evaluations. METHODS: This multisite, pre- and post-evaluation used individual-level data from 22 produce prescription locations in 12 US states from 2014 to 2020. No programs were previously evaluated. The study included 3881 individuals (2064 adults aged 18+ years and 1817 children aged 2–17 years) with, or at risk for, poor cardiometabolic health recruited from clinics serving low-income neighborhoods. Programs provided financial incentives to purchase F&V at grocery stores or farmers markets (median, $63/months; duration, 4–10 months). Surveys assessed F&V intake, food security, and self-reported health; glycated hemoglobin, blood pressure, body mass index (BMI), and BMI z -score were measured at clinics. Adjusted, multilevel mixed models accounted for clustering by program. RESULTS: After a median participation of 6.0 months, F&V intake increased by 0.85 (95% CI, 0.68–1.02) and 0.26 (95% CI, 0.06–0.45) cups per day among adults and children, respectively. The odds of being food insecure dropped by one-third (odds ratio, 0.63 [0.52–0.76]) and odds of improving 1 level in self-reported health status increased for adults (odds ratio, 1.62 [1.30–2.02]) and children (odds ratio, 2.37 [1.70–3.31]). Among adults with glycated hemoglobin ≥6.5%, glycated hemoglobin declined by −0.29% age points (−0.42 to −0.16); among adults with hypertension, systolic and diastolic blood pressures declined by −8.38 mm Hg (−10.13 to −6.62) and −4.94 mm Hg (−5.96 to −3.92); and among adults with overweight or obesity, BMI decreased by −0.36 kg/m 2 (−0.64 to −0.09). Child BMI z -score did not change −0.01 (−0.06 to 0.04). CONCLUSIONS: In this large, multisite evaluation, produce prescriptions were associated with significant improvements in F&V intake, food security, and health status for adults and children, and clinically relevant improvements in glycated hemoglobin, blood pressure, and BMI for adults with poor cardiometabolic health.

6 October 2014 in PLOS ONE
Verified
Journal Article
Open access
PDF file
SASelena Ahmed
Selena Ahmed
JSJohn Richard Stepp
John Richard Stepp
COColin Mark Orians
Colin Mark Orians
TGTimothy Griffin
Timothy Griffin
CMCorene Matyas
Corene Matyas
EKEdward Kennelly
Edward Kennelly
Climate change is impacting agro-ecosystems, crops, and farmer livelihoods in communities worldwide. While it is well understood that more frequent and intense climate events in many areas are resulting in a decline in crop yields, the impact on crop quality is less acknowledged, yet it is critical for food systems that benefit both farmers and consumers through high-quality products. This study examines tea (Camellia sinensis; Theaceae), the world's most widely consumed beverage after water, as a study system to measure effects of seasonal precipitation variability on crop functional quality and associated farmer knowledge, preferences, and livelihoods. Sampling was conducted in a major tea producing area of China during an extreme drought through the onset of the East Asian Monsoon in order to capture effects of extreme climate events that are likely to become more frequent with climate change. Compared to the spring drought, tea growth during the monsoon period was up to 50% higher. Concurrently, concentrations of catechin and methylxanthine secondary metabolites, major compounds that determine tea functional quality, were up to 50% lower during the monsoon while total phenolic concentrations and antioxidant activity increased. The inverse relationship between tea growth and concentrations of individual secondary metabolites suggests a dilution effect of precipitation on tea quality. The decrease in concentrations of tea secondary metabolites was accompanied by reduced farmer preference on the basis of sensory characteristics as well as a decline of up to 50% in household income from tea sales. Farmer surveys indicate a high degree of agreement regarding climate patterns and the effects of precipitation on tea yields and quality. Extrapolating findings from this seasonal study to long-term climate scenario projections suggests that farmers and consumers face variable implications with forecasted precipitation scenarios and calls for research on management practices to facilitate climate adaptation for sustainable crop production.

3 October 2023 in Nature Communications
Verified
Journal Article
Open access
PDF file
LCLaura Lara Castor
Laura Lara Castor
RMRenata Micha
Renata Micha
FCFrederick Cudhea
Frederick Cudhea
VMVictoria Miller
Victoria Miller
PSPeilin Shi
Peilin Shi
DMDariush Mozaffarian
Dariush Mozaffarian
Sugar-sweetened beverages (SSBs) are associated with cardiometabolic diseases and social inequities. For most nations, recent estimates and trends of intake are not available; nor variation by education or urbanicity. We investigated SSB intakes among adults between 1990 and 2018 in 185 countries, stratified subnationally by age, sex, education, and rural/urban residence, using data from the Global Dietary Database. In 2018, mean global SSB intake was 2.7 (8 oz = 248 grams) servings/week (95% UI 2.5-2.9) (range: 0.7 (0.5-1.1) in South Asia to 7.8 (7.1-8.6) in Latin America/Caribbean). Intakes were higher in male vs. female, younger vs. older, more vs. less educated, and urban vs. rural adults. Variations by education and urbanicity were largest in Sub-Saharan Africa. Between 1990 and 2018, SSB intakes increased by +0.37 (+0.29, +0.47), with the largest increase in Sub-Saharan Africa. These findings inform intervention, surveillance, and policy actions worldwide, highlighting the growing problem of SSBs for public health in Sub-Saharan Africa.

1 August 2018 in Food Policy
Verified
Journal Article
Closed access
RBRebecca Boehm
Rebecca Boehm
PWParke E. Wilde
Parke E. Wilde
MPMichele Ver Ploeg
Michele Ver Ploeg
CCChristine Costello
Christine Costello
Sean CashSean Cash
Sean Cash