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Aristotle University of Thessaloniki
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235 Members

Basic Info

Latest Publications
Journal Article
Expert Systems with Applications
Published: 01 September 2024 in Expert Systems with Applications
ACS Style

Eleftherios Kouloumpris; Konstantinos Moutsianas; Ioannis Vlahavas. SABER: Stochastic-Aware Bootstrap Ensemble Ranking for portfolio management. Expert Systems with Applications 2024, 249 .

AMA Style

Eleftherios Kouloumpris, Konstantinos Moutsianas, Ioannis Vlahavas. SABER: Stochastic-Aware Bootstrap Ensemble Ranking for portfolio management. Expert Systems with Applications. 2024; 249 ():.

Chicago/Turabian Style

Eleftherios Kouloumpris; Konstantinos Moutsianas; Ioannis Vlahavas. 2024. "SABER: Stochastic-Aware Bootstrap Ensemble Ranking for portfolio management." Expert Systems with Applications 249, no. : .

Journal Article
Magnetic Resonance Imaging
Published: 01 September 2024 in Magnetic Resonance Imaging
ACS Style

Christos G. Xanthis; Robert Jablonowski; Sebastian Bidhult-Johansson; David Nordlund; Anna-Bettina Haidich; Tania Lala; Håkan Arheden; Anthony H. Aletras. Unravelling the mechanisms of CE-SSFP in imaging myocardium at risk: The effect of relaxation times on myocardial contrast. Magnetic Resonance Imaging 2024, 111, 90 -102.

AMA Style

Christos G. Xanthis, Robert Jablonowski, Sebastian Bidhult-Johansson, David Nordlund, Anna-Bettina Haidich, Tania Lala, Håkan Arheden, Anthony H. Aletras. Unravelling the mechanisms of CE-SSFP in imaging myocardium at risk: The effect of relaxation times on myocardial contrast. Magnetic Resonance Imaging. 2024; 111 ():90-102.

Chicago/Turabian Style

Christos G. Xanthis; Robert Jablonowski; Sebastian Bidhult-Johansson; David Nordlund; Anna-Bettina Haidich; Tania Lala; Håkan Arheden; Anthony H. Aletras. 2024. "Unravelling the mechanisms of CE-SSFP in imaging myocardium at risk: The effect of relaxation times on myocardial contrast." Magnetic Resonance Imaging 111, no. : 90-102.

Journal Article
Medicinal Chemistry
Published: 01 August 2024 in Medicinal Chemistry

Neuro-inflammation is a complex phenomenon resulting in several disorders. ALOX-5, COX-2, pro-inflammatory enzymes, and amino acid neurotransmitters are tightly correlated to neuro- inflammatory pathologies. Developing drugs that interfere with these targets will offer treatment for various diseases. Herein, we extend our previous research by synthesizing a series of multitarget hybrids of cinnamic acids with amino acids recognized as neurotransmitters. The synthesis was based on an in silico study of a library of cinnamic amide hybrids with glycine, γ- aminobutyric, and L - glutamic acids. Drug-likeness and ADMET properties were subjected to in silico analysis. Cinnamic acids were derived from the corresponding aldehydes by Knoevenagel condensation. The synthesis of the amides followed a two-step reaction with 1-hydroxybenzotriazole monohydrate and 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride in dry dichloromethane and the corresponding amino acid ester hydrochloride salt in the presence of N,N,-diisopropyl-Nethylamine. The new compounds, such as lipoxygenase, cyclooxygenase-2, lipid peroxidation inhibitors, and anti-inflammatories, were tested in vitro. The compounds exhibited LOX inhibition with IC50 values in the low μM region. Compounds 18a, 23b, and 11c are strong lipid peroxidation inhibitors (99%, 78%, and 92%). Compound 28c inhibits SLOX-1 with IC50 =8.5 μM whereas 11a and 22a highly inhibit COX-2 (IC50 6 and 5 μM). Hybrids 14c and 17c inhibit both enzymes. Compound 29c showed the highest anti-inflammatory activity (75%). The in silico ADMET properties of 14c and 11a support their drug-likeness.

ACS Style

Ioannis Fotopoulos; Eleni Pontiki; Dimitra Hadjipavlou-Litina. Pharmacochemical Study of Multitarget Amino Acids’ Hybrids: Design, Synthesis, In vitro, and In silico Studies. Medicinal Chemistry 2024, 20, 709 -720.

AMA Style

Ioannis Fotopoulos, Eleni Pontiki, Dimitra Hadjipavlou-Litina. Pharmacochemical Study of Multitarget Amino Acids’ Hybrids: Design, Synthesis, In vitro, and In silico Studies. Medicinal Chemistry. 2024; 20 (7):709-720.

Chicago/Turabian Style

Ioannis Fotopoulos; Eleni Pontiki; Dimitra Hadjipavlou-Litina. 2024. "Pharmacochemical Study of Multitarget Amino Acids’ Hybrids: Design, Synthesis, In vitro, and In silico Studies." Medicinal Chemistry 20, no. 7: 709-720.

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