Griffith University

Hyaluronic acid (HA) hydrogels, obtained through cross-linking, provide a stable 3D environment that is important for controlled delivery and tissue engineering applications. Cross-linking density has a significant impact on the physicochemical properties of hydrogels, including their shape stability, mechanical stiffness and macromolecular diffusivity. However, often cross-linking chemistries require photoinitiator and catalyst that may be toxic and cause unwanted tissue response. Here, we prepared a series of HA hydrogel with varying cross-linker length and cross-linking density, which can be obtained by altering the feed ratio of three different cross-linkers from small molecules to macromolecules (e.g., 1,4-butanediol diglycidyl ether (BDDE), ferulic acid (FA), pluronic (PLU)), to ameliorate skin wrinkles in mice models. HA cross-linked with FA and PLU exhibited enzyme and temperature-dependent sol-to-gel phase transition, respectively, and the gels possess good injectability. In vitro test confirmed that HA hydrogels co-cultured with RAW 264.7 and HDF cells showed good biocompatibility. In particular, HA cross-linked with PLU stimulated the growth of HDF cells and HaCaT cells. HA cross-linked with PLU suppressed the expression levels of proteins involved in collagen degradation including mitogen-activated protein kinases (ERK, JNK, p38) and matrix metalloproteases (MMP-1, MMP-3, and MMP-9) resulting in increased deposition of Collagen I. The free-flowing sols of HA hydrogel precursors are subcutaneously injected into the back of BALB/c mice and form stable gels at the dermis layer and found to be non-toxic. More importantly, HA hydrogel cross-linked with PLU showed an enhanced anti-wrinkling effect in the wrinkled mice model. Thus, properties of HA hydrogels such as injectability, biocompatibility, and good anti-wrinkling effect altered through varying cross-linking density must be considered in the context of soft tissue engineering applications.

Mohanapriya Murugesan; Ramya Mathiyalagan; Zelika Mega Ramadhania; Qihui Zhou; Se Chan Kang; Thavasyappan Thambi. Tailoring hyaluronic acid hydrogels: Impact of cross-linker length and density on skin rejuvenation as injectable dermal fillers and their potential effects on the MAPK signaling pathway suppression. Bioactive Materials 2025, 49, 154 -171.

Mohanapriya Murugesan, Ramya Mathiyalagan, Zelika Mega Ramadhania, Qihui Zhou, Se Chan Kang, Thavasyappan Thambi. Tailoring hyaluronic acid hydrogels: Impact of cross-linker length and density on skin rejuvenation as injectable dermal fillers and their potential effects on the MAPK signaling pathway suppression. Bioactive Materials. 2025; 49 ():154-171.

Mohanapriya Murugesan; Ramya Mathiyalagan; Zelika Mega Ramadhania; Qihui Zhou; Se Chan Kang; Thavasyappan Thambi. 2025. "Tailoring hyaluronic acid hydrogels: Impact of cross-linker length and density on skin rejuvenation as injectable dermal fillers and their potential effects on the MAPK signaling pathway suppression." Bioactive Materials 49, no. : 154-171.

Purpose: Law enforcement personnel are often exposed to critical incidents and are at risk of post-traumatic psychopathologies. The purpose of this systematic review is to synthesize and evaluate recent empirical research about primary and secondary prevention strategies designed to reduce the risk of law enforcement officers developing post-traumatic disorders.Design/methodology/approach: The study used a systematic review approach guided by the Institute of Medicine’s Standards for Systematic Reviews and Preferred Reporting Items for Systematic Reviews and Meta-Analyses.Findings: In total, 13 articles were deemed relevant to the question of evidence for prevention programs intended to reduce the development of post-traumatic psychopathologies in law enforcement officers. Our review found these indicated a lack of evidence for the efficacy of prevention programs. Seven of the articles included in this review focused on Critical Incident Stress Debriefing (CISD), providing no evidence to support CISD as a secondary prevention strategy for law enforcement officers. The remaining six studies focused on diverse prevention approaches including resilience training, imagery and psychosocial support, with limited evidence available.Originality/value: Interestingly, despite a plethora of literature in this area, our review indicates a lack of high-quality studies investigating effective prevention approaches for law enforcement personnel. Given the potentially significant impact of post-traumatic stress disorder and other conditions associated with work-related trauma for law enforcement organizations, there is a clear need to undertake high-quality research into preventative measures in this area.

Christine Randall; Nicole White; Nicholas Buys; Mary G. Carey; Wayne Corneil; Alex Fraess-Phillips. Law enforcement personnel: systematic review of the impact of prevention programs following exposure to work-related trauma. Policing: An International Journal 2025, ahead-of-p .

Christine Randall, Nicole White, Nicholas Buys, Mary G. Carey, Wayne Corneil, Alex Fraess-Phillips. Law enforcement personnel: systematic review of the impact of prevention programs following exposure to work-related trauma. Policing: An International Journal. 2025; ahead-of-p (ahead-of-p):.

Christine Randall; Nicole White; Nicholas Buys; Mary G. Carey; Wayne Corneil; Alex Fraess-Phillips. 2025. "Law enforcement personnel: systematic review of the impact of prevention programs following exposure to work-related trauma." Policing: An International Journal ahead-of-p, no. ahead-of-p: .

Purpose: This study aims to examine the impact of digital literacy as a major component of digital inequality on the total income of individuals (a major component of economic inequality) in Sri Lanka, emphasizing the variations observed due to several demographic and geographical factors. Design/methodology/approach: A baseline regression analysis using ordinary least squares was conducted, followed by an instrumental variable approach to address potential endogeneity. Variables such as age, education, gender, sector and employment status were included alongside digital literacy to examine their combined effect on total income. A logit model assessed digital literacy’s impact across income levels, while heterogeneity analysis explored how digital literacy influenced total income in diverse groups with distinct attributes. Findings: This study reveals that digital literacy significantly increases total income for individuals in Sri Lanka, as affirmed by various analyses used in the study. Results further indicate that demographic characteristics, such as age, gender, level of education, location, employment status and digital literacy, significantly affect individuals’ total income. Originality/value: This study contributes to the literature in multiple ways by exploring the impact of digital literacy on income inequalities by concentrating on different strata of society without focusing on one segment of society, focusing on individuals in a developing country in South Asia to investigate the income inequalities based on their level of digital literacy and using Labour Force Survey data to conduct research on digital inclusion and digital inequality.

Prabath Perera; Selva Selvanathan; Saroja Selvanathan; Jen-Je Su; Maneka Jayasinghe. From digital inequality to income inequality: exploring the multifaceted impact of digital literacy on income. Digital Policy, Regulation and Governance 2025, ahead-of-p .

Prabath Perera, Selva Selvanathan, Saroja Selvanathan, Jen-Je Su, Maneka Jayasinghe. From digital inequality to income inequality: exploring the multifaceted impact of digital literacy on income. Digital Policy, Regulation and Governance. 2025; ahead-of-p (ahead-of-p):.

Prabath Perera; Selva Selvanathan; Saroja Selvanathan; Jen-Je Su; Maneka Jayasinghe. 2025. "From digital inequality to income inequality: exploring the multifaceted impact of digital literacy on income." Digital Policy, Regulation and Governance ahead-of-p, no. ahead-of-p: .