Humanitas University

Francesco Tartaglia; Mauro Gitto; Pier Pasquale Leone; Mauro Chiarito; Gianmaria Calamita; Gianluca Mincione; Gabriele Gasparini; Bernhard Reimers; Ottavia F. Cozzi; Marco L. Rossi; Giulio G. Stefanini; Damiano Regazzoli; Antonio Mangieri; Antonio Colombo. Validation of complex PCI criteria in drug-coated balloon angioplasty. Clinical Research in Cardiology 2025, 1 -12.

Francesco Tartaglia, Mauro Gitto, Pier Pasquale Leone, Mauro Chiarito, Gianmaria Calamita, Gianluca Mincione, Gabriele Gasparini, Bernhard Reimers, Ottavia F. Cozzi, Marco L. Rossi, Giulio G. Stefanini, Damiano Regazzoli, Antonio Mangieri, Antonio Colombo. Validation of complex PCI criteria in drug-coated balloon angioplasty. Clinical Research in Cardiology. 2025; ():1-12.

Francesco Tartaglia; Mauro Gitto; Pier Pasquale Leone; Mauro Chiarito; Gianmaria Calamita; Gianluca Mincione; Gabriele Gasparini; Bernhard Reimers; Ottavia F. Cozzi; Marco L. Rossi; Giulio G. Stefanini; Damiano Regazzoli; Antonio Mangieri; Antonio Colombo. 2025. "Validation of complex PCI criteria in drug-coated balloon angioplasty." Clinical Research in Cardiology , no. : 1-12.

Sebastien Elvinger; Stephanie G Kuehne; Andrea Patrignani; Maximilian Tscharre; Matthias Freynhofer; Leor Perl; Ran Kornowski; Francesca Cesari; Rossella Marcucci; Laura Novelli; Isabell Bernlochner; Philip W Raake; Mauro Chiarito; Dario Bongiovanni. Sex-specific predictive value of reticulated platelets in coronary artery disease: A systematic review and meta-analysis. 2025, e70078 .

Sebastien Elvinger, Stephanie G Kuehne, Andrea Patrignani, Maximilian Tscharre, Matthias Freynhofer, Leor Perl, Ran Kornowski, Francesca Cesari, Rossella Marcucci, Laura Novelli, Isabell Bernlochner, Philip W Raake, Mauro Chiarito, Dario Bongiovanni. Sex-specific predictive value of reticulated platelets in coronary artery disease: A systematic review and meta-analysis. . 2025; ():e70078.

Sebastien Elvinger; Stephanie G Kuehne; Andrea Patrignani; Maximilian Tscharre; Matthias Freynhofer; Leor Perl; Ran Kornowski; Francesca Cesari; Rossella Marcucci; Laura Novelli; Isabell Bernlochner; Philip W Raake; Mauro Chiarito; Dario Bongiovanni. 2025. "Sex-specific predictive value of reticulated platelets in coronary artery disease: A systematic review and meta-analysis." , no. : e70078.

Introduction: This large, multicenter, Italian retrospective study aimed to describe clinical characteristics and risk factors associated with 30-day mortality in patients with Pseudomonas aeruginosa bloodstream infections (PA-BSI) admitted to internal medicine wards (IMW). To enhance clinical decision-making, we also developed and internally validated a bedside prognostic model to predict the 30-day mortality risk. Methods: We conducted a retrospective, multicenter cohort study across 14 public hospitals in Italy, analyzing all adult patients admitted to IMW with PA-BSI between 2021 and 2022. Results: Out of 285 eligible patients with PA-BSI, the median age was 73 years, and septic shock occurred in 13.3% of cases. Less than 5% of PA-BSI were caused by difficult-to-treat resistant P. aeruginosa (DTR-PA). Encouragingly, appropriate empiric therapy was administered in 69.8% of patients, yet the overall 30-day mortality remained 22.5%. Cox regression analysis identified age, and urinary catheter use as significant risk factors for mortality. Conversely, adequate source control and targeted therapy emerged as protective factors. Multivariate analysis confirmed septic shock at bloodstream infection onset (HR 6.96; 95% CI, 1.72–28.12) as a strong independent predictor of mortality, whereas effective source control (HR 0.152; 95% CI, 0.039–0.59) significantly improved survival odds. Using these insights, we developed a practical prognostic model capable of estimating the 30-day mortality risk, providing clinicians with a valuable predictive tool at the bedside. Conclusions: PA-BSI in IMWs is characterized by a relatively low incidence of septic shock and rate of resistance, alongside high rates of appropriate empiric therapy. Despite these favorable factors, meropenem may represent a valuable therapeutic option for PA-BSI with severe presentations in this setting since mortality remains substantial (22.5%). Our findings underscore the critical importance of early source control and identify septic shock as a key predictor of mortality even in the setting of IMW. The proposed bedside nomogram model could empower clinicians to identify high-risk patients early, facilitating timely interventions and improving outcomes in this vulnerable population.

Silvia Corcione; Simone Mornese Pinna; Antonio Vena; Michela Schenone; Maura Sanino; Renato Pascale; Emanuele Pivetta; Daniele Roberto Giacobbe; Maddalena Giannella; Nour Shbaklo; Davide Bavaro; Eleonora Taddei; Vincenzo Scaglione; Veronica Vassia; Benedetta Fumarola; Michele Bartoletti; Pierluigi Viale; Matteo Bassetti; Francesco Giuseppe De Rosa; on behalf of SITA GIOVANI (Young Investigators Group of the Società Italiana Terapia Antinfettiva). Pseudomonas aeruginosa bloodstream infections in internal medicine wards: A large Italian multicenter retrospective study. PLOS ONE 2025, 20, e0317540 .

Silvia Corcione, Simone Mornese Pinna, Antonio Vena, Michela Schenone, Maura Sanino, Renato Pascale, Emanuele Pivetta, Daniele Roberto Giacobbe, Maddalena Giannella, Nour Shbaklo, Davide Bavaro, Eleonora Taddei, Vincenzo Scaglione, Veronica Vassia, Benedetta Fumarola, Michele Bartoletti, Pierluigi Viale, Matteo Bassetti, Francesco Giuseppe De Rosa, on behalf of SITA GIOVANI (Young Investigators Group of the Società Italiana Terapia Antinfettiva). Pseudomonas aeruginosa bloodstream infections in internal medicine wards: A large Italian multicenter retrospective study. PLOS ONE. 2025; 20 (5):e0317540.

Silvia Corcione; Simone Mornese Pinna; Antonio Vena; Michela Schenone; Maura Sanino; Renato Pascale; Emanuele Pivetta; Daniele Roberto Giacobbe; Maddalena Giannella; Nour Shbaklo; Davide Bavaro; Eleonora Taddei; Vincenzo Scaglione; Veronica Vassia; Benedetta Fumarola; Michele Bartoletti; Pierluigi Viale; Matteo Bassetti; Francesco Giuseppe De Rosa; on behalf of SITA GIOVANI (Young Investigators Group of the Società Italiana Terapia Antinfettiva). 2025. "Pseudomonas aeruginosa bloodstream infections in internal medicine wards: A large Italian multicenter retrospective study." PLOS ONE 20, no. 5: e0317540.