Cervical cancer represents a major health problem among females due to its increased mortality rate. The conventional therapies are very aggressive and unsatisfactory when it comes to survival rate, especially in terminal stages, which requires the development of new treatment alternatives. With the use of nanotechnology, various chemotherapeutic drugs can be transported via nanocarriers directly to cervical cancerous cells, thus skipping the hepatic first-pass effect and decreasing the rate of chemotherapy side effects. This review comprises various drug delivery systems that were applied in cervical cancer, such as lipid-based nanocarriers, polymeric and dendrimeric nanoparticles, carbon-based nanoparticles, metallic nanoparticles, inorganic nanoparticles, micellar nanocarriers, and protein and polysaccharide nanoparticles. Nanoparticles have a great therapeutic potential by increasing the pharmacological activity, drug solubility, and bioavailability. Through their mechanisms, they highly increase the toxicity in the targeted cervical tumor cells or tissues by linking to specific ligands. In addition, a nondifferentiable model is proposed through holographic implementation in the dynamics of drug delivery dynamics. As any hologram functions as a deep learning process, the artificial intelligence can be proposed as a new analyzing method in cervical cancer.

The purpose of this study was to analyze the published cases regarding large ovarian masses in adolescents, in order to find useful clinical implications for the diagnosis and management of the condition. The methodology employed a systematic review of reported cases of large/giant ovarian tumor in adolescence. The main objective was to assess the imagery findings, histology of the tumor, and the type of surgery performed. Our study included 58 patients with the tumor diameters ranged between 11 and 42 cm, with a median value of 22.75 cm and a mean diameter of 24.66 ± 8.50 cm. The lesions were benign in 47 cases (81%), borderline in 2 cases (3.4%), and malign in 9 cases (15.6%). We found no statistically significant difference (p > 0.05) between the size of the tumors and the ovarian markers levels. At the same time, a statistically significant difference was identified (p=<0,001) between elevated levels of the serum markers and the malignant tumor type (OR = 12.45; CI95 = 2.55-94.77). The main types of surgery performed were cystectomy (35 cases), oophorectomy (4 cases), salpingo-oophorectomy (18 cases). Open laparotomy was performed in 46 cases on tumors with a median diameter of 25 ± 8.8 cm, while laparoscopy was done in 12 cases on tumors with a median diameter of 23.7 ± 7.6 cm. For optimal surgical management, it is advisable to assess first the imagery findings and tumor markers. Then, the laparoscopic approach should be considered as a feasible option, especially in cases where there are no predictive factors for a malign disease.

Background and Objectives: The most utilized approach for the embolization of uterine arteries is the transfemoral path. However, the transradial approach (TRA) has been gaining popularity among cardiologic interventions in the last years but only few studies have shown its applicability in uterine myoma treatment. The objective of this paper is to assess the feasibility, safety and efficacy of TRA when compared with the transbrachial, transulnar or transfemoral approach (TFA) for uterine arteries embolization (UAE). Materials and methods: A systematic review of the literature that analyzes the TRA for UAE it was carried out, in order to assess its safety and effectiveness. It was systematically searched the literature (Google Scholar, PubMed/MEDLINE, Cochrane Library and Embase) using the words “uterine artery embolization”/“uterine embolization” and “transradial”/“radial”. All the relevant papers published until March 2020 were retrieved and analyzed. Results: Ten studies were considered eligible for this topic. TRA is a comparable method with TFA for uterine artery embolization. Conclusions: These studies allowed us to conclude that TRA is as safe and efficient as TFA. Its advantages include few complications, shorter hospitalization period, and rapid mobilization but a steeper learning curve has the disadvantage of a longer learning curve compared to TFA. Yet, these findings are built on few reports and more research is needed.

The aim of the paper is to identify the of optimal plastic type used in obtaining thoraco-lumbar orthoses - used in the treatments of comminutive fracture, of burst fracture type of the vertebrae in the lumbar area. For this purpose, with the help of Finite Element Analysis (FEA), a theoretical study was carried out on the influence of elastic properties of plastics, used in the achieving of lumbar orthoses, on the state of tension and on the local displacements of the bone fragments from the traumatized area under the condition of the movement from the base of extension and flexion. In the study the force of flexion, the force of extension and the elastic modulus of plastic material varied on three levels. The theoretical results obtained were completed with clinical trials carried out on a total of 26 patients who suffer thoraco-lumbar comminutive fracture, burst fractures type, at vertebra T11 and were immobilized in Boston-type plastic orthoses made of: polypropylene (PP), rigid vinyl polychloride (PVC-D) and polytetrafluoroethylene (PTFE). As a result of observations, it was found that the use of an orthesis made from rigid plastic material, although it appears higher stresses in the traumatized zone, the displacements of bone fragments are smaller, the pains is higher in the fractured zone, the angle of kyphosis (LKA) close to the normal value and a better mobility of the spine (ODI indicator).

Endometriosis is considered a serious public health issue because of the large number of females affected by this illness. Chronic pain management in patients with endometriosis demands new strategies to increase the life quality of these patients. The development of drug delivery systems represents a new approach in pain treatment among endometriosis patients. Diclofenac sodium, one of the most utilized nonsteroidal anti-inflammatory drugs (NSAID), has its own limitations when being used in formulas such as oral, parental, or local applications. In this paper, a series of four drug release formulations based on chitosan, 2-hydroxy-5-nitrobenzaldehyde, and diclofenac sodium salt were prepared in view of the investigation of the drug release ability. The formulations were analyzed from a morphological and supramolecular point of view by scanning electron microscopy and polarized light microscopy. The in vitro drug release ability was investigated by mimicking a physiologic environment. A mathematical model, using the fractal paradigm of motion, is utilized to explain the behaviors of the drug delivery system presented in this paper. These results suggest a great potential of the proposed drug delivery system, based on chitosan and 2-hydroxy-5-nitrobenzaldehyde to improve the diclofenac sodium salt bioavailability, and it may represent a future treatment formula for endometriosis pain.

Two different operational procedures are proposed for evaluating and predicting the onset of epileptic and eclamptic seizures. The first procedure analyzes the electrical activity of the brain (EEG signals) using nonlinear dynamic methods (the time variations of the standard deviation, the variance, the skewness and the kurtosis; the evolution in time of the spatial–temporal entropy; the variations of the Lyapunov coefficients, etc.). The second operational procedure reconstructs any type of EEG signal through harmonic mappings from the usual space to the hyperbolic one using the time homographic invariance of a multifractal-type Schrödinger equation in the framework of the scale relativity theory (i.e., in a multifractal paradigm of motions). More precisely, the explicit differential descriptions of the brain activity in the form of 2 × 2 matrices with real elements disclose, through the in-phase coherences at various scale resolutions (i.e., as scale transitions), the multitude of brain neuronal dynamics, especially sequences of epileptic and eclamptic seizures. These two operational procedures are not mutually exclusive, but rather become complementary, offering valuable information concerning epileptic and eclamptic seizures. In such context, the prediction of epileptic and eclamptic seizures becomes fundamental for patients not responding to medical treatment and also presenting an increased rate of seizure recurrence.