Rationale: Promotion of mitophagy is considered a promising strategy for the treatment of neurodegenerative diseases including Alzheimer's disease (AD). The development of mitophagy-specific inducers with low toxicity and defined molecular mechanisms is essential for the clinical application of mitophagy-based therapy. The aim of this study was to investigate the potential of a novel small-molecule mitophagy inducer, ALT001, as a treatment for AD.

The aim of this study was to examine whether rubrofusarin, an active ingredient of the Cassia species, has an antidepressive effect in chronic restraint stress (CRS) mouse model. Although acute treatment using rubrofusarin failed, chronic treatment using rubrofusarin ameliorated CRS-induced depressive symptoms. Rubrofusarin treatment significantly reduced the number of Fluoro-Jade B-positive cells and caspase-3 activation within the hippocampus of CRS-treated mice. Moreover, rubrofusarin treatment significantly increased the number of newborn neurons in the hippocampus of CRS-treated mice. CRS induced activation of glycogen synthase kinase-3β and regulated development and DNA damage responses, and reductions in the extracellular-signal-regulated kinase pathway activity were also reversed by rubrofusarin treatment. Microglial activation and inflammasome markers, including nod-like receptor family pyrin domain containing 3 and adaptor protein apoptosis-associated speck-like protein containing CARD, which were induced by CRS, were ameliorated by rubrofusarin. Synaptic plasticity dysfunction within the hippocampus was also rescued by rubrofusarin treatment. Within in vitro experiments, rubrofusarin blocked corticosterone-induced long-term potentiation impairments. These were blocked by LY294002, which is an Akt inhibitor. Finally, we found that the antidepressant effects of rubrofusarin were blocked by an intracerebroventricular injection of LY294002. These results suggest that rubrofusarin ameliorated CRS-induced depressive symptoms through PI3K/Akt signaling.

The power distribution network (PDN) of a high-speed printed circuit board requires a high-performance power supply. The total equivalent inductance above the top ground plane is an important part of PDN design and is regarded as L _above . In this paper, an inductance library for different structures of capacitor connections and capacitor sizes has been built, which is essential for PDN design. computer simulation technology (CST) and partial element equivalent circuit method are applied to obtain the shorted pattern design curves at various design data. The shorted pattern design curve means the total equivalent inductance varies with the distance between pad and ground plane. In addition, an approximate shorted model is established for a decoupling capacitor-mounted model, which will be convenient for us to get the inductance of L _above . In this paper, the design curve provides an intuitive guideline in designing PDN and facilitates the industry to choose what they want with consideration of the inductance, space, via numbers, etc.

In this paper, frequency dependent target impedance is proposed for optimal Power Distribution Network (PDN) design. Target impedance indicates how much and where decoupling capacitors should be located in the PDNs therefore it directly affects performance of the electrical systems or manufacturing cost. In this paper, frequency dependent target impedance considering IC's power current spectrum is proposed. Based on the proposed target impedance, GPU's VDD PDN is designed so that the hierarchical PDN impedance is maintained bellow the proposed target impedance in frequency domain. We simulated designed PDN with GPU chip's signal model in the time domain to verify the proposed target impedance. Simultaneous Switching Noise (SSN) in the GPU chip PDN was suppressed bellow the target which is 5% of the supply voltage based on proposed design. Compared to the conventional target impedance, proposed target impedance allowed more flexible design and at the same time satisfied the design criterion.

Wireless power transfer (WPT) is an emerging technology deployed for a wide range of applications. Various design challenges need to be addressed at both circuit and system levels. However, the conventional modeling methods either require impractical assumptions or only focus on the coil-to-coil part. This article presents a system-level model for WPT applications, including all the critical interior blocks, such as power amplifier, transmitter coil, receiver coil, matching networks, and rectifier. An accurate characterization method is proposed to obtain the rectifier impedance as a realistic load condition. Then, through frequency harmonic analysis, the power capabilities along the power flow path are analytically derived for both the fundamental and higher order harmonic components. The system efficiency and the power loss at each block can be accurately estimated. As a result, this model can not only optimize the system performance, but also help improve the thermal design for WPT products. With the assistance of this improved model, a practical design methodology is introduced to optimize the system parameters. An experimental prototype is built to validate the proposed model and the design methodology. Good correlations are observed between the calculations and experiments in both the time-domain and frequency-domain results.