Factories use many manufacturing processes that consume a lot of energy and highly contribute in greenhouse gas emissions. The introduction of the concept of Industrial Internet in USA and Industry 4.0 in Europe offers many opportunities to reduce energy consumption in these factories. Introducing and utilizing smart techniques for the applications pertinent to manufacturing processes within the Industry 4.0 domain can offer many benefits for reducing energy consumption in smart factories. This paper investigates and discusses these opportunities and benefits. The paper also discusses the roles of Industry 4.0 technologies in enabling these opportunities. Consequently, introducing these capabilities will help significantly reduce both production costs and greenhouse gas emissions. The paper then provides a benefit analysis that shows the advantages of such leverage. In addition, the paper offers an enabling architecture and its components that includes cyber-physical system (CPS) manufacturing services layer, fog manufacturing services layer, cloud manufacturing services layer, and blockchain-based service-oriented middleware to support such opportunities.

Smart cities are becoming a reality. Various aspects of modern cities are being automated and integrated with information and communication technologies to achieve higher functionality, optimized resources utilization, and management, and improved quality of life for the residents. Smart cities rely heavily on utilizing various software, hardware, and communication technologies to improve the operations in areas, such as healthcare, transportation, energy, education, logistics, and many others, while reducing costs and resources consumption. One of the promising technologies to support such efforts is the Cloud of Things (CoT). CoT provides a platform for linking the cyber parts of a smart city that are executed on the cloud with the physical parts of the smart city, including residents, vehicles, power grids, buildings, water networks, hospitals, and other resources. Another useful technology is Fog Computing, which extends the traditional Cloud Computing paradigm to the edge of the network to enable localized and real-time support for operating-enhanced smart city services. However, proper integration and efficient utilization of CoT and Fog Computing is not an easy task. This paper discusses how the service-oriented middleware (SOM) approach can help resolve some of the challenges of developing and operating smart city services using CoT and Fog Computing. We propose an SOM called SmartCityWare for effective integration and utilization of CoT and Fog Computing. SmartCityWare abstracts services and components involved in smart city applications as services accessible through the service-oriented model. This enhances integration and allows for flexible inclusion and utilization of the various services needed in a smart city application. In addition, we discuss the implementation and experimental issues of SmartCityWare and demonstrate its use through examples of smart city applications.

Protein-protein interaction (PPI) is essential to most biological processes. Abnormal interactions may have implications in a number of neurological syndromes. Given that the association and dissociation of protein molecules is crucial, computational tools capable of effectively identifying PPI are desirable. In this paper, we propose a simple yet effective method to detect PPI based on pairwise similarity and using only the primary structure of the protein. The PPI based on Pairwise Similarity (PPI-PS) method consists of a representation of each protein sequence by a vector of pairwise similarities against large subsequences of amino acids created by a shifting window which passes over concatenated protein training sequences. Each coordinate of this vector is typically the E-value of the Smith-Waterman score. These vectors are then used to compute the kernel matrix which will be exploited in conjunction with support vector machines.