Nicholas Clark

Dr. Nicholas Clark

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Research Focus & Metrics

Academic Career Length

14Years (2013-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 March 2018 in The Annals of Applied Statistics
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Journal Article
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NCNicholas Clark
Nicholas Clark
PDPhilip M. Dixon
Philip M. Dixon
Spatio-temporal hierarchical modeling is an extremely attractive way to model the spread of crime or terrorism data over a given region, especially when the observations are counts and must be modeled discretely. The spatio-temporal diffusion is placed, as a matter of convenience, in the process model allowing for straightforward estimation of the diffusion parameters through Bayesian techniques. However, this method of modeling does not allow for the existence of self-excitation, or a temporal data model dependency, that has been shown to exist in criminal and terrorism data. In this manuscript we will use existing theories on how violence spreads to create models that allow for both spatio-temporal diffusion in the process model as well as temporal diffusion, or self-excitation, in the data model. We will further demonstrate how Laplace approximations similar to their use in Integrated Nested Laplace Approximation can be used to quickly and accurately conduct inference of self-exciting spatio-temporal models allowing practitioners a new way of fitting and comparing multiple process models. We will illustrate this approach by fitting a self-exciting spatio-temporal model to terrorism data in Iraq and demonstrate how choice of process model leads to differing conclusions on the existence of self-excitation in the data and differing conclusions on how violence spread spatially-temporally in that country from 2003–2010.

8 February 2022 in Biology
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Journal Article
Open access
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Francesco CampaFrancesco Campa
Francesco Campa
DTDiana M Thomas
Diana M Thomas
KWKrista Watts
Krista Watts
NCNicholas Clark
Nicholas Clark
DBDaniel Paul Baller
Daniel Paul Baller
ASAnaliza M. Silva
Analiza M. Silva
The present study aimed to develop reference values for bioelectrical phase angle in male and female athletes from different sports. Overall, 2224 subjects participated in this study [1658 males (age 26.2 ± 8.9 y) and 566 females (age 26.9 ± 6.6 y)]. Participants were categorized by their sport discipline and sorted into three different sport modalities: endurance, velocity/power, and team sports. Phase angle was directly measured using a foot-to-hand bioimpedance technology at a 50 kHz frequency during the in-season period. Reference percentiles (5th, 15th, 50th, 85th, and 95th) were calculated and stratified by sex, sport discipline and modality using an empirical Bayesian analysis. This method allows for the sharing of information between different groups, creating reference percentiles, even for sports disciplines with few observations. Phase angle differed (men: p < 0.001; women: p = 0.003) among the three sport modalities, where endurance athletes showed a lower value than the other groups (men: vs. velocity/power: p = 0.010, 95% CI = −0.43 to −0.04; vs. team sports: p < 0.001, 95% CI = −0.48 to −0.02; women: vs. velocity/power: p = 0.002, 95% CI = −0.59 to −0.10; vs. team sports: p = 0.015, 95% CI = −0.52 to −0.04). Male athletes showed a higher phase angle than female athletes within each sport modality (endurance: p < 0.01, 95% CI = 0.63 to 1.14; velocity/power: p < 0.01, 95% CI = 0.68 to 1.07; team sports: p < 0.01, 95% CI = 0.98 to 1.23). We derived phase angle reference percentiles for endurance, velocity/power, and team sports athletes. Additionally, we calculated sex-specific references for a total of 22 and 19 sport disciplines for male and female athletes, respectively. This study provides sex- and sport-specific percentiles for phase angle that can track body composition and performance-related parameters in athletes.

1 August 2020 in Obesity
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DTDiana M Thomas
Diana M Thomas
RSRodney Sturdivant
Rodney Sturdivant
NDNikhil V. Dhurandhar
Nikhil V. Dhurandhar
SDSwati Debroy
Swati Debroy
NCNicholas Clark
Nicholas Clark
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2 or COVID‐19) disease has led to a wide‐spread global pandemic (1). COVID‐19 symptoms and mortality are disproportionately more severe in people with obesity and obesity related comorbidities (2, 3). This is of concern for the United States, where ~42% have obesity and of these, 85% have type 2 diabetes.

10 December 2013 in Knee Surgery, Sports Traumatology, Arthroscopy
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Journal Article
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BWBrian R. Waterman
Brian R. Waterman
KCKenneth L. Cameron
Kenneth L. Cameron
MHMark Hsiao
Mark Hsiao
JLJoseph R. Langston
Joseph R. Langston
NCNicholas Clark
Nicholas Clark
BOBrett D. Owens
Brett D. Owens

24 September 2019 in The American Journal of Clinical Nutrition
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Journal Article
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DTDiana M Thomas
Diana M Thomas
NCNicholas Clark
Nicholas Clark
DTDusty Turner
Dusty Turner
CSCynthia Siu
Cynthia Siu
THTanya M Halliday
Tanya M Halliday
DADavid B Allison
David B Allison
Regression to the mean (RTM) is a statistical phenomenon where initial measurements of a variable in a nonrandom sample at the extreme ends of a distribution tend to be closer to the mean upon a second measurement. Unfortunately, failing to account for the effects of RTM can lead to incorrect conclusions on the observed mean difference between the 2 repeated measurements in a nonrandom sample that is preferentially selected for deviating from the population mean of the measured variable in a particular direction. Study designs that are susceptible to misattributing RTM as intervention effects have been prevalent in nutrition and obesity research. This field often conducts secondary analyses of existing intervention data or evaluates intervention effects in those most at risk (i.e., those with observations at the extreme ends of a distribution). To provide best practices to avoid unsubstantiated conclusions as a result of ignoring RTM in nutrition and obesity research. We outlined best practices for identifying whether RTM is likely to be leading to biased inferences, using a flowchart that is available as a web-based app at https://dustyturner.shinyapps.io/DecisionTreeMeanRegression/. We also provided multiple methods to quantify the degree of RTM. Investigators can adjust analyses to include the RTM effect, thereby plausibly removing its biasing influence on estimating the true intervention effect. The identification of RTM and implementation of proper statistical practices will help advance the field by improving scientific rigor and the accuracy of conclusions. This trial was registered at clinicaltrials.gov as NCT00427193.

2 January 2020 in Journal of Statistics Education
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Journal Article
Open access
KCKevin Cummiskey
Kevin Cummiskey
BABryan Adams
Bryan Adams
JPJames Pleuss
James Pleuss
DTDusty Turner
Dusty Turner
NCNicholas Clark
Nicholas Clark
KWKrista Watts
Krista Watts
Over the last two decades, statistics educators have made important changes to introductory courses. Current guidelines emphasize developing statistical thinking in students and exposing them to the entire investigative process in the context of interesting research questions and real data. As a result, many concepts (confounding, multivariable models, study design, etc.) previously reserved only for higher-level courses now appear in introductory courses. Despite these changes, causality is rarely discussed in introductory courses, except for warning students “correlation does not imply causation” or covering the special case of randomized controlled experiments. In this paper, we argue causal inference concepts align well with statistics education guidelines for introductory courses by developing statistical and multivariable thinking, exposing students to many aspects of the investigative process, and fostering active learning. We discuss how to integrate causal inference concepts into introductory courses using causal diagrams and provide an illustrative example with youth smoking data. Through our website, we also provide a guided student activity and instructor resources.