Decision-makers from the Slovenian healthcare system have generally failed to look beyond the information and communication technology, while trying to implement highly intricate and expensive eHealth project. Accordingly, functional integration of planned information and communication technology solutions with various business aspects of the healthcare system has remained largely ignored, while the existing and obsolete business model of the Slovenian healthcare system continues to operate significantly limited and unadapted to the increasing and ubiquitous penetration of information and communication technologies into the healthcare environment. This article explores the characteristics and structure of the business model concept, identifies the impending effects of informatization on the healthcare business model, and finally provides a framework for information and communication technology-induced transformation of the existing healthcare business model in Slovenia. The research is based on the case study evidence and structured interviews with the distinguished experts from the cross-sectional areas of the healthcare system strongly related to the business model concept. Research results imply that effective transformation of the healthcare business model should consider various factors from the healthcare ecosystem, including a redefinition of the functions and relationships of and between the main actors of the business model, and the reconfiguration of the organizational, structural, and technological elements in line with the long-term business objectives.

According to rough estimates, there are approximately 150,000 rare disease patients in Slovenia (out of a total population of 2 million). Despite the absence of accurate epidemiological data on their status, these figures reveal the great importance of this area for the Slovenian healthcare system. Consistent monitoring in the field of rare diseases facilitates evidence-informed healthcare policies, comprehensive observation of rare disease patients, and consequently serves increasingly demanding medical and statistical needs. This paper initially explores the current situation concerning rare diseases and identifies related challenges for the planned development of a national rare disease registry in Slovenia. Based on the research findings, the paper outlines the construction of the pilot rare disease registry and conceptualizes the establishment of a rare disease ecosystem in Slovenia. The research is based on a case study design, where focus group sessions were used as the main data collection technique. Structured discussions were conducted with 24 eminent experts affiliated with the leading institutions in the field of rare diseases in Slovenia. Analysis and interpretations of the data obtained were carried by means of conventional content analysis. A subsequent course of action for developing the pilot rare disease registry and conceptualizing the rare disease ecosystem was formulated in collaboration with the experts participating in the focus groups. The research results indicate that the effective development of the national rare disease registry, followed by the establishment of the rare disease ecosystem in Slovenia, requires a broad approach that entails a whole series of systemic changes and considerations. Moreover, well-orchestrated and well-funded efforts to achieve this goal should involve the coordinated action of all stakeholders, including the amendment of the regulatory framework, quality design, and enactment of a general rare disease policy, as well as the alignment of medical, organizational, and technological aspects in accordance with the long-term public healthcare objectives. The establishment of a rare disease ecosystem in Slovenia and probably elsewhere, including a national rare disease registry, would represent an important improvement for patients, as it could significantly contribute to more coordinated healthcare treatment and enable comprehensive monitoring of the treatment process and results. A well-organized rare disease ecosystem could bring considerable benefits to healthcare system managers by providing a useful platform for estimating the required resources, evidence-informed policymaking, technological innovation, and organizational restructuring. This research provides valuable insight into the background of the issues that many countries face in the field of rare diseases, and ultimately provides practical recommendations for the development of national rare disease registries. However, ensuring effective healthcare delivery in this intricate field is critically dependent on the harmonization of digital solutions with other systemic factors and the adaptation of the rare disease ecosystem to the patients’ needs and the specifics of the healthcare environment.

This paper analyses the role and significance of the selected factors for the successful design and implementation of public policies in Slovenia and more broadly. Based on structured interviews and content analysis of the responses, we investigated the impact of predefined factors (i.e. strategic, institutional, normative, economic/financial, methodological/procedural, organisational/human resources/ICT support factors). The aim of the article is to analyse the case of Slovenia, to identify which factors contribute most to the successful design and implementation of public policies, and to provide a basis for comparison with similar countries or systems. The research findings imply several conclusions, particularly strategic factors, which have been identified as the most essential. The other findings are related to the lack of evaluation practice, the discontinuity of and early changes in government, which affect all aspects of policy execution and lead to poor intersectoral collaboration as well as insufficient and ineffective public debate. Not surprisingly, all of the identified hindrances are featured in the pertinent theories as necessary democratic dimensions of contemporary public governance. Contrary to the national context, the EU influence seems to expedite policymaking processes and contribute to the consistency of policies.

While Electronic Prescription Systems (EPS) adoption varies across EU Member States, there's a lack of comprehensive comparative analysis. Existing studies focus on single EPSs, employ diverse methodologies, and lack up-to-date data. This study fills this gap by providing a comprehensive overview of EPS development, functionalities, and usage statistics in each EU Member State. Most EU Member States widely adopted EPS by 2022, with exceptions including Germany, France, and Luxembourg, where pilot projects or just plans existed at that time. Out of the 27 EPSs, 25 employ a similar design featuring a central server and end-user software or web-based applications. Among these, 22 are structured as single national systems. The fundamental technical solution is remarkably similar across the EU. Despite these similarities, functionalities, authentication methods, prescription validity, and medication coverage differ significantly among EPSs. A multinational team, including co-authors from each EU Member State, collected data using a structured questionnaire. The study underscores the need for standardized methodologies in EPS research and emphasizes the importance of comprehensive comparative analysis to inform healthcare policies and digitalization efforts.

Epidemiological studies indicate that exposure to ultrafine particles (UFP) in ambient air represents an important environmental public health issue. The aim of this study was to determine the association between UFP in ambient air and the daily number of consultations in the primary health care unit due to diabetes mellitus in children and elderly population of the Municipality of Ljubljana. A 5-year time-trend ecological study was carried out for the period between 1 January 2013 and 31 December 2017. The daily number of primary health care consultations due to diabetes mellitus among children and elderly population was observed as the health outcome. Daily mean UFP concentrations (different size from 10 to 100 nm) were measured and calculated. Poisson regression analysis was used to investigate the association between the observed outcome and the daily UFP, particulate matter fine fraction (PM_2.5), and particulate matter coarse fraction (PM₁₀) concentrations, adjusted to other covariates. The results show that the daily number of consultations due to diabetes mellitus were highly significantly associated with the daily concentrations of UFP (10 to 20 nm; p ≤ 0.001 and 20 to 30 nm; p ≤ 0.001) in all age groups and in the elderly population. In observed the population of children, we did not confirm the association. Findings indicate that specified environmental challenges should be addressed by comprehensive public health strategies leading to the coordinated cross-sectoral measures for the reduction of UFP in ambient air and the mitigation of adverse health effects.