The constant strain rate loading and dynamic stress equilibrium are prerequisites for ensuring the experimental data of the Split Hopkinson Pressure Bar (SHPB). In order to achieve this requirement, a proper pulse shaper dimensions were used in the experiment. For this purpose, the pulse shaper diameter, thickness and strength and the strike bar length and its velocity on the incident pulse are studied by ∅80mm SHPB apparatus. Then, the parameters affecting the two key inflection points and three loading areas of the incident pulse are discussed. In addition, the improved methods for two typical non-constant strain rate waveforms for the concrete experiments are obtained based on the regular pulse shaping. Moreover, SHPB experiments are conducted for concrete by employing different pulse shaper dimensions. The results show that more valid data can be obtained by employing the pulse shaper with large thickness when the strain rate is non-constant during the experiment. The conclusions and method provide guidance for selecting pulse shaper for concrete SHPB experiments.

Idiopathic pulmonary fibrosis (IPF) is a chronic progressive interstitial pulmonary disease characterized with radiographically evident pulmonary infiltrates and extracellular matrix deposition with limited treatment options. We previously described that microcystin-LR (MC-LR) reduces transforming growth factor (TGF)-β1/Smad signaling and ameliorates pulmonary fibrosis in bleomycin (BLM)-induced rat models. In the present study, we further demonstrate that microcystin-RR (MC-RR), an MC congener with lower toxicity than MC-LR, exerted an anti-fibrotic effect on BLM-induced pulmonary fibrosis rodent models and compared it with MC-LR. Our data show that MC-RR treatment attenuated BLM-associated pulmonary inflammation and collagen deposition in both therapeutic and preventive models. MC-RR reduced the expression of fibrotic markers, including vimentin, α-smooth muscle actin, collagen 1α1, and fibronectin, in rat pulmonary tissues. Furthermore, the core features of BLM-induced pulmonary fibrotic lesions were better alleviated by MC-RR than by MC-LR. MC-RR treatment substantially decreased the number of pulmonary M2 macrophages. In vitro, MC-RR attenuated the epithelial-mesenchymal transition and fibroblast-myofibroblast transition triggered by M2 macrophages. Therefore, we highlight MC-RR as a promising molecule for developing therapeutic and prophylactic strategies against IPF, a refractory lung disease.

Based on mechanical properties of Polyamide 66 (PA66) under complex loading conditions, a Drucker–Prager yield criterion was employed to characterize its yield behavior. Then, a one-dimensional model, which contains a viscoelastic regime and a viscoplastic regime, was introduced and converted into a three-dimensional constitutive model. The three-dimensional model was implemented into a LS-DYNA software, which was used to predict the dynamic response of PA66 under Taylor impact conditions, whose corresponding tests were conducted by gas gun and recorded by high-speed camera. By contrasting the simulation results and these of the corresponding tests, the deformed shapes including the residual length, the maximum diameter and the shape of the mushroom head of the PA66 bars were found to be similar to these obtained from the tests, which verified the accuracy of the three-dimensional constitutive model, and proved that the model was able to be applied to high-rate impact loading conditions.

In order to study the critical ricochet velocity and critical penetration velocity of tungsten alloy rod obliquely penetrating a finite-thickness metal plate, experiment and numerical calculation of tungsten alloy rod impacting on homogeneous armor steel plate with a thickness of 30mm at an angle of 60° were carried out. Compared the experimental and numerical results with the results using models, it is found that, the results of the ricochet models proposed by Tate, Rosenberg and Steven B for semi-infinite thick plate are quite different from those of experiment and numerical calculation, so they can not be applied to the ricochet situation of finite-thickness plate. The critical penetration velocity model proposed by De Marre and Zhao are in good agreement with the numerical and experimental results, which can predict critical penetration velocity of tungsten alloy rod obliquely penetrating a finite-thickness metal plate with large impact angle. The penetration depth of the projectile under the critical ricochet velocity is about 1/3 of the thickness of the target plate, and the angle between the ejection trajectory of the fragments produced by projectile and target plate and projectile penetration trajectory is exactly 90° in the first penetration stage.

In order to increase the penetration ability of tungsten fiber-reinforced Zr-based bulk metallic glasses matrix composite rod, two multi-diameter tungsten fiber-reinforced Zr-based bulk metallic glasses matrix composites (MD-WF/Zr-MG) are designed. In MD-WF/Zr-MG-I, the diameters of tungsten fiber (WF) increase gradually from the inside to outside, which is the opposite in MD-WF/Zr-MG-II. Penetration experiment of two kinds of MD-WF/Zr-MG rods into rolled homogeneous armor (RHA) steel target from 1470 m/s to 1630 m/s is conducted. The average penetration depth of the MD-WF/Zr-MG-II rod is higher than that of the MD-WF/Zr-MG-I rod. Penetration failure modes of MD-WF/Zr-MG-I and MD-WF/Zr-MG-II rods are bending, backflow of WFs and shear failure respectively. The failure mode of MD-WF/Zr-MG is affected by the bend spaces and the ultimate bending diameters of WFs. If the bend spaces of all WFs are equal or larger than their ultimate bending diameters, the penetration failure mode is the bending and backflow of WFs, oppositely the penetration failure mode is the shear failure. The MD-WF/Zr-MG rod with shear failure exhibits high penetration ability because of low penetration resistance and little residual material in the crater. When designing MD-WF/Zr-MG, bend spaces of a part of WFs should be smaller than their ultimate bending diameter to cause shear failure.