Prof. Letizia Angiolella
Sapienza, University of Rome, Department of Public Health and Infectious Deseases. Piazzale Aldo Moro, 5, 00100 Roma, Italy
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Academic Career Length
44Years (1983-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
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Journal Article
Gökhan Zengin
LUIGI MENGHINI
Antonella Di SottoRMRomina Mancinelli
Romina Mancinelli
Francesca Sisto
Rossella Grande +10
Due to renewed interest in the cultivation and production of Italian Cannabis sativa L., we proposed a multi-methodological approach to explore chemically and biologically both the essential oil and the aromatic water of this plant. We reported the chemical composition in terms of cannabinoid content, volatile component, phenolic and flavonoid pattern, and color characteristics. Then, we demonstrated the ethnopharmacological relevance of this plant cultivated in Italy as a source of antioxidant compounds toward a large panel of enzymes (pancreatic lipase, α-amylase, α-glucosidase, and cholinesterases) and selected clinically relevant, multidrug-sensible, and multidrug-resistant microbial strains (Staphylococcus aureus, Helicobacter pylori, Candida, and Malassezia spp.), evaluating the cytotoxic effects against normal and malignant cell lines. Preliminary in vivo cytotoxicity was also performed on Galleria mellonella larvae. The results corroborate the use of this natural product as a rich source of important biologically active molecules with particular emphasis on the role exerted by naringenin, one of the most important secondary metabolites.
1 March 1996 in The Journal of Infectious Diseases
Journal Article
Letizia AngiolellaMFMonica Facchin
Monica Facchin
Annarita StringaroBMBruno Maras
Bruno Maras
NSNicola Simonetti
Nicola Simonetti
ACAntonio Cassone
Antonio Cassone
Growth-subinhibitory nonlytic doses of cilofungin (a lipopeptide antibiotic affecting (1,3)-β-d-glucan synthesis) inhibited the incorporation of 46- to 48-kDa glucan-associated (46K) protein into the growing cell wall of Candida albicans. The purified 46K protein constituent strongly reacted with a monoclonal antibody against enolase, a major cytoplasmic enzyme of the fungus. In addition, two internal fragments of 12- and IS-amino acid residues from a tryptic digest of 46K protein showed 100% identity with amino acids in positions 34–45 and 66–80 of enolase. By immunoelectron microscopy with polyclonal and monoclonal anti-enolase antibodies, the 46K protein was clearly detected in the inner layers of the fungal cell wall. Thus, consistent with the proposed immunogenic and diagnostic roles of enolase in candidiasis, biochemical, immunochemical, and ultrastructural evidence strongly suggest that the cilofungin-susceptible 46K protein is a cell wall-associated form of this enzyme.
7 July 2005 in Journal of Medicinal Chemistry
Journal Article
RSRoberto Di Santo
Roberto Di SantoATAndrea Tafi
Andrea Tafi
Roberta CostiMBMaurizo Botta
Maurizo Botta
MAMarino Artico
Marino Artico
APAnna Teresa Palamara
Anna Teresa Palamara +4
1 May 2014 in Phytomedicine
Journal Article
LCLivia Civitelli
Livia CivitelliSPSimona Panella
Simona Panella
MMMaria Elena Marcocci
Maria Elena MarcocciAPAlberto De Petris
Alberto De Petris
SGStefania Garzoli
Stefania Garzoli
Letizia Angiolella +5
Journal Article
Since ancient times, plants have been used to preserve food, or for their health properties. Essential oils are complex mixtures of volatile compounds that are obtained from botanical material, specifically from aromatic plants. Lamiaceae is one of the most important families in the production of essential oils, as it has both antioxidant and antimicrobial properties. The essential oils of Mentha (the Lamiaceae family) have been extensively studied for their biological actions. In this review, we report the antioxidant, antifungal, antibiofilm, and cytotoxic properties of Mentha spp. essential oils. The first objective is to provide comprehensive information about the use of essential oils in the treatment of fungal infections, or as antioxidants and integrative anticancer therapy. The second is to explore the evidence supporting its effectiveness in treating diseases without causing any serious adverse reactions.
10 May 2016 in Journal of Enzyme Inhibition and Medicinal Chemistry
Journal Article
Simone CarradoriPCPaola Chimenti
Paola Chimenti
MFMarina Fazzari
Marina Fazzari
AGArianna Granese
Arianna Granese
Letizia AngiolellaThe limited arsenal of synthetic antifungal agents and the emergence of resistant Candida strains have prompted the researchers towards the investigation of naturally occurring compounds or their semisynthetic derivatives in order to propose new innovative hit compounds or new antifungal combinations endowed with reduced toxicity. We explored the anti-Candida effects, for the first time, of two bioactive compounds from Crocus sativus stigmas, namely crocin 1 and safranal, and some semisynthetic derivatives of safranal obtaining promising biological results in terms of minimum inhibitory concentration/minimum fungicidal concentration (MIC/MFC) values, synergism and reduction in the germ tube formation. Safranal and its thiosemicarbazone derivative 5 were shown to display good activity against Candida spp.
About Me
1981—Graduated in Biological Sciences at the University of Rome “La Sapienza”;
1982-1983—Winner of two scholarships in Infectious Diseases;
1988—PhD in Experimental Medicine at the Faculty of Medicine and Surgery of the University of Rome “La Sapienza”;
1990—Graduated from the Faculty of Pharmacy;
2001—Researcher in Microbiology;
2006—Associate Professor in the Faculty of Pharmacy and Medicine of the University of Rome Sapienza;
Since the year 2001, he has carried out didactic activity teaching Microbiology (MED/07) in the degree courses of Pharmacy, Herbal Products Science and Technology, Applied Pharmaceutical Sciences, and Medicine. He also covers Mycology courses for Specialization Schools in Microbiology and Virology and Hospital Pharmacy. His research activity is characterized by the production of high impact scientific work mainly concerning the following:
1) The study of drug resistance mechanisms and their possible implication in virulence in C. albicans and other yeasts such as Malassezia spp.
2) The study of the antifungal activity of new synthetic and/or natural molecules.
He is the author of 66 scientific publications in national and international peer-reviewed journals, the co-author of two patents, and the author of chapters of books and three curations.