Purpose.: To investigate microrobots as an assistive tool for minimally invasive intraocular surgery and to demonstrate mobility and controllability inside the living rabbit eye. Methods.: A system for wireless magnetic control of untethered microrobots was developed. Mobility and controllability of a microrobot are examined in different media, specifically vitreous, balanced salt solution (BSS), and silicone oil. This is demonstrated through ex vivo and in vivo animal experiments. Results.: The developed electromagnetic system enables precise control of magnetic microrobots over a workspace that covers the posterior eye segment. The system allows for rotation and translation of the microrobot in different media (vitreous, BSS, silicone oil) inside the eye. Conclusions.: Intravitreal introduction of untethered mobile microrobots can enable sutureless and precise ophthalmic procedures. Ex vivo and in vivo experiments demonstrate that microrobots can be manipulated inside the eye. Potential applications are targeted drug delivery for maculopathies such as AMD, intravenous deployment of anticoagulation agents for retinal vein occlusion (RVO), and mechanical applications, such as manipulation of epiretinal membrane peeling (ERM). The technology has the potential to reduce the invasiveness of ophthalmic surgery and assist in the treatment of a variety of ophthalmic diseases.

Within only a few decades from its initial introduction, the field of surgical robotics has evolved into a dynamic and rapidly growing research area with increasing clinical uptake worldwide. Initially introduced for stereotaxic neurosurgery, surgical robots are now involved in an increasing number of procedures, demonstrating their practical clinical potential while propelling further advances in surgical innovations. Emerging platforms are also able to perform complex interventions through only a single-entry incision, and navigate through natural anatomical pathways in a tethered or wireless fashion. New devices facilitate superhuman dexterity and enable the performance of surgical steps that are otherwise impossible. They also allow seamless integration of microimaging techniques at the cellular level, significantly expanding the capabilities of surgeons. This paper provides an overview of the significant achievements in surgical robotics and identifies the current trends and future research directions of the field in making surgical robots safer, smaller, and smarter.

Concentric tube robots are catheter-sized continuum robots that are well suited for minimally invasive surgery inside confined body cavities. These robots are constructed from sets of precurved superelastic tubes and are capable of assuming complex 3-D curves. The family of 3-D curves that the robot can assume depends on the number, curvatures, lengths, and stiffnesses of the tubes in its tube set. The robot design problem involves solving for a tube set that will produce the family of curves necessary to perform a surgical procedure. At a minimum, these curves must enable the robot to smoothly extend into the body and to manipulate tools over the desired surgical workspace while respecting anatomical constraints. This paper introduces an optimization framework that utilizes procedure- or patient-specific image-based anatomical models along with surgical workspace requirements to generate robot tube set designs. The algorithm searches for designs that minimize robot length and curvature and for which all paths required for the procedure consist of stable robot configurations. Two mechanics-based kinematic models are used. Initial designs are sought using a model assuming torsional rigidity. These designs are then refined using a torsionally compliant model. The approach is illustrated with clinically relevant examples from neurosurgery and intracardiac surgery.

Microrobots are promising tools for micromanipulation and minimally invasive interventions. Robust electromagnetic control of microrobots can be achieved through precisely modeled magnetic steering systems and accurate localization. Error-free modeling and position information, however, are not realistic assumptions, and microrobots need to be controlled under force and localization uncertainties. In this paper, methods to account for these types of uncertainties are presented. Initially, the uncertainties in electromagnetic force generation of a new class of manipulation systems are quantified. Subsequently, a drag-force uncertainty model for linear dynamics is proposed. This model can be employed for microrobots whose fluid dynamics are not well understood. A set of performance measures is introduced in the design of controllers, and a PID and a robust H _∞ controller are synthesized and evaluated through simulations. To demonstrate the capabilities of the synthesized controllers under localization and force uncertainties, low update rates are considered. The H _∞ controller can provably respect the performance measures under higher uncertainties than the PID controller, and its performance is further quantified through experiments in a prototype electromagnetic control system.