With the rapid development of photo-responsive nanomaterials, photo-triggered therapeutic strategies such as photothermal therapy (PTT) and photodynamic therapy (PDT) have been new alternatives to current cancer therapeutic methods. Herein, we have fabricated oxygen vacancy-engineered BaTiO3 (BTO-Ov) nanoparticles (NPs) for near-infrared (NIR) light-triggered PTT, PDT, and catalytic therapy cooperatively for significantly improving cancer therapy. Compared to pristine BaTiO3 nanoparticles, BTO-Ov has stronger NIR light absorption and narrower band gap structure, which results in superior photothermal conversion and superoxide radical generation capabilities through PTT and PDT. Meanwhile, due to the existence of Ti3+, BTO-Ov also exhibits peroxidase (POD)-like activity to produce hydroxyl radical under tumor environment, which can be further improved under 808 nm light irradiation. Both in vitro and in vivo results demonstrate that such a multifunctional therapeutic nanoplatform can achieve a high therapeutic efficacy triggered by a single NIR light irradiation. The defect engineering strategy can be used as a general approach to fabricate multifunctional cancer therapeutic nanoplatform.
7 March 2023 in Journal of Colloid and Interface Science
Separative extended-gate AlGaAs/GaAs high electron mobility transistor (HEMT) biosensors based on the capacitance change strategy are proposed and fabricated. The working mechanism underlying this strategy is clearly clarified via examining the capacitance evolution on biorecognition and the capacitance matching issue between the HEMT and the sensing pad. The fabricated biosensors demonstrate a good linear current/voltage response to a label-free prostate-specific antigen (PSA) target over a broad concentration range of 100 fg/ml to 10 ng/ml in both 0.1× and 1× phosphate buffered saline solutions. Specifically, the sensitivity variation approaches 8.7% dec−1 at the critical concentration level of 2–8 ng/ml that enters the normal PSA region in the human body. The advantages of high sensitivity, low-cost, and convenience of usage make the proposed HEMT biosensors potential candidates for prostate cancer diagnosis.
Space charge capacitance and the physical mechanism of negative capacitance in organic light-emitting diodes (OLEDs) by transient current response analysis are investigated for the first time.
Electrochemical etching is a promising wet etching technology for preparing porous structures and the flat surface etching of 4H-SiC. In this study, the effects of current density and KOH concentration on the etching of 4H-SiC were investigated. We found that the respective mechanisms for preparing porous structures and flat surface etching differed. The porous and flat etching modes were proposed to clarify the mechanistic differences. In addition, we achieved an etch rate of 1 μm h−1 in flat etching mode, and the sample surface was improved for 4H-SiC applications in the field of optoelectronics and microelectronics through the thermal oxidation of SiC.