Thien Hien Tran

Thien Hien Tran


Research Focus & Metrics

Academic Career Length

8Years (2019-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

View All Publications
16 November 2019 in Asian Journal of Chemistry
Verified
Journal Article
Open access
TTThi Ngan Tran
Thi Ngan Tran
TTThien Hien Tran
Thien Hien Tran
XLXuan Tien Le
Xuan Tien Le
TATrieu Tuan Anh
Trieu Tuan Anh
Minh Quan PHAMMinh Quan PHAM
Minh Quan PHAM
TTTrần Quốc Toàn
Trần Quốc Toàn
In this study, kaffir lime peel was used for extraction of essential oil by hydrodistillation and evaluation of physico-chemical characteristics. The yield of essential oil was 1.8 %. The physico-chemical parameters averaged specific gravity (0.8587g/cm3), acid index (0.667 mg KOH/g), ester index (4.203 mg KOH/g), refractive index (1.469), rotator power +3. Twenty-three components were classified in kaffir lime peel oils. The result of GC-MS revealed that the oil is extremely rich in α-pinene (35.54 %), Eucalyptol (20.902 %), camphene (4.384 %), bicyclo[3.1.1]hept-3-en-2-one (7.794 %), caryophyllene (1.225 %), endo-borneol (4.147 %), bornyl acetate (4.065%). The aim of this study is to promote for further research on extraction enhancement and application of that constituents to cosmetics, medicine and food industries to enhance antioxidant and anti-bacterial capabilities create more useful formulations

28 August 2022 in Processes
Verified
Journal Article
Open access
PDF file
HHHiệp Phú Hoàng
Hiệp Phú Hoàng
KVKhang Pham Van
Khang Pham Van
TTThien Hien Tran
Thien Hien Tran
DPDung Pham
Dung Pham
Cinnamomum verum (Cinnamomum genus) essential oil is commonly used in food preparation and traditional medicines, with a broad spectrum of biological activities. However, research on the extraction of essential oils (EOs) from C. verum cultivated locally in Vietnam is currently limited. Therefore, in this study, the chemical compositions and bioactivities of EOs from the bark and leaves of C. verum collected from the Thai Nguyen and Yen Bai provinces of Vietnam were investigated. The EOs samples were extracted by using water distillation, organic solvent (n-hexane) and ultrasound-assisted (in n-hexane solvent) extraction methods. The chemical composition of the obtained EOs were analyzed by GC-FID and GC/MS analyses. Results showed that the major chemical compositions of C. verum EOs were: (E)-cinnamaldehyde, trans-cinnamic acid, cinnamyl acetate, and benzaldehyde. Furthermore, C. verum EOs exhibited inhibitory activities against two tested cancer cell lines and four bacterial strains. These findings provide essential knowledge about the potential application of C. verum EOs cultivated in Vietnam for the pharmaceutical industry.

8 October 2022 in Processes
Verified
Journal Article
Open access
PDF file
LKLe Trung Khoang
Le Trung Khoang
HHHoang Thi Thu Huyen
Hoang Thi Thu Huyen
HCHuynh Van Chung
Huynh Van Chung
LDLe Xuan Duy
Le Xuan Duy
TTTrần Quốc Toàn
Trần Quốc Toàn
TTThien Hien Tran
Thien Hien Tran
Polyscias fruticosa (L.) Harms is commonly used for medicinal purposes in Vietnam. In traditional medicine, the plant is used to cure ischemia, reduce inflammation, and increase cerebral blood circulation. Triterpene saponins are the major chemical constituents found in the roots of P. fruticosa. This compound exhibited a broad spectrum of biological effects, including lowering blood sugar, suppressing tumor growth and inflammation. This study focused on optimizing the process of total saponins extraction from P. fruticosa roots using the ultrasonic-assisted extraction (UAE) method, ethanol solvent and response surface methodology, and Box–Behnken design model, then evaluating the cytotoxic effect against some cancer cell lines. The results showed that under the optimal conditions, including an extraction temperature of 60 °C and ultrasonic power of 185 W in 65 min, the maximum extraction yield and total saponin content were 14.51 ± 1.15% and 41.24 ± 1.68 mg/g, respectively. Moreover, the saponin extract had cytotoxic effects against A549, HepG2, PC-3, and Hela. The results of this study confirmed that triterpene saponin is an important chemical component which is present in a high content in P. fruticosa roots and gives rise to significant biological activities. In addition, UAE can be used as a highly efficient method for triterpene saponins extraction from P. fruticosa roots.

1 December 2020 in IOP Conference Series: Materials Science and Engineering
Verified
Conference Paper
Open access
PDF file
TTT Q Toan
T Q Toan
TTT T Truc
T T Truc
XLX T Le
X T Le
NQN T C Quyen
N T C Quyen
TTThien Hien Tran
Thien Hien Tran
This study attempted the extraction of essential oils (EOs) from orange peel, and optimized the experimental parameters of the microwave-assisted hydrodistillation process. Gas chromatography-Mass spectrometry was often used for the assessment of the chemical content of the natural oils collected. Optimal conditions for the extraction process consisted of the ratio of 1:3 peel/water, microwave power of 300W and duration of 45 minutes. These conditions gave the highest yield (2%). From the gas chromatographic results, five components were identified in the obtained orange peel EOs with Limonene being the major components (98.416%). Based on availability, orange peel is suggested as an economically viable source for limonene production. Obtained results are expected to aid in mitigation of environmental impact caused by agricultural wastes.

25 February 2020 in Asian Journal of Chemistry
Verified
Journal Article
Open access
NQNguyen Thi Ngoc Quyen
Nguyen Thi Ngoc Quyen
HLHuynh Thi Kieu Linh
Huynh Thi Kieu Linh
TNThuy Trang Le Ngoc
Thuy Trang Le Ngoc
HAHoang Le Tuan Anh
Hoang Le Tuan Anh
NNNguyen Hong Khoi Nguyen
Nguyen Hong Khoi Nguyen
HMHuỳnh Cang Mai
Huỳnh Cang Mai
In present study, a steam distillation method has been adopted for extraction of the essential oil from Vietnamese lemon (Citrus aurantifolia) peel harvested from Tien Giang Province, Vietnam. Various extraction conditions influencing the oil yield were investigated. The resulting essential oil was evaluated for physico-chemical characteristics and antibacterial activities. The chemic al composition of oil was investigated by GC-MS. The results showed that with grinded lemon peel, a ratio of water and lemon peels of 3:1 (mL/g), extraction time of 90 min at 120 ºC, the highest essential oil yield was attained at 2.1 %. Bioactive components found at high content included limonene (64.90 %), γ-terpinene (13.70 %), β-pinene (11.89 %), α-pinene (2.11 %), β-cymene (1.80 %) and sabinen (1.52 %). The lemon essential oil in this study was found to inhibit five bacteria strains including Staphylococcus aureus, Bacillus cereus, Escherichia coli, Salmonella enterica and Pseudomonas aeruginosa.

22 December 2023 in Processes
Verified
Journal Article
Open access
PDF file
HHHiệp Phú Hoàng
Hiệp Phú Hoàng
TTThien Hien Tran
Thien Hien Tran
KVKhang Pham Van
Khang Pham Van
This study investigated the chemical compositions and inhibitory activities of essential oils (EOs) of Salix babylonica from Vietnam. The gas chromatography–mass spectrometry (GC/MS) system was used to analyze the chemical compositions of Salix babylonica essential oils. A total of twenty-eight and thirty-one compounds were identified in essential oils of the leaves and bark, among which many chemical compositions were identified for the first time in this plant. Salix babylonica essential oils demonstrated antibacterial activities against Gram-negative strains such as Pseudomonas aeruginosa (PA) and Escherichia coli and Gram-positive strains such as Staphylococcus aureus (SA), and demonstrated anti-cancer activities against three cancer cell lines (HepG2, MCF-7 cell, and A549). The evaluation of the ability to inhibit three strains of microorganisms and inhibit the growth of three cancer cell lines was first conducted using essential oils extracted from the plant species S. babylonica collected in Asia, which will be the basis for using essential oils of this plant in medicine.