Frequency response analysis (FRA) has recently been developed as a widely accepted tool for power transformer winding mechanical deformation diagnosis, and has proven to be effective and powerful in many cases. However, there still exist problems regarding the application of FRA. FRA is a comparative method in which the measured FRA signature should be compared with its fingerprint. Small differences of FRA signatures in certain frequency bands might be produced by external disturbance, which hinders fault diagnosis. Additionally, the existing correlation coefficient indicator recommended by power industry standards cannot reflect key information of signatures, namely the extreme points. This paper proposes an improved FRA based on binary morphology and extreme point variation. Binary morphology is first introduced to extract the certain frequency bands of signatures with significant difference. A composite indicator of extreme point variation is adopted to realize the diagnosis of fault level. A ternary diagram is constructed by the area proportions of the binary image to identify winding faults, which has a potential to realize cluster analysis of fault types.

Objective: To minimize the effect of muscle contractions during irreversible electroporation (IRE), this paper attempts to research the ablation effect and muscle contractions by applying high-frequency IRE (H-FIRE) ablation to liver tissue in vivo. Methods: An insulated needle electrode was produced by painting an insulating coating on the outer surface of the needle electrode tip. A series of experiments were conducted using insulated needle electrodes and traditional needle electrodes to apply H-FIRE pulses and traditional monopolar IRE pulses to rabbit liver tissues. The finite element model of the rabbit liver tissue was established to determine the lethal thresholds of H-FIRE in liver tissues. Muscle contractions were measured by an accelerometer. Results: With increased constitutive pulse width and pulse voltage, the ablation area and muscle contraction strength are also increased, which can be used to optimize the ablation parameters of H-FIRE. Under the same pulse parameters, the ablation areas are similar for the two types of electrodes, and the ablation region has a clear boundary. H-FIRE and insulated needle electrodes can mitigate the extent of muscle contractions. The lethal thresholds of H-FIRE in rabbit liver tissues were determined. Conclusion: This paper describes the relationships between the ablation area, muscle contractions, and pulse parameters; the designed insulated needle electrodes can be used in IRE for reducing muscle contraction. Significance: The study provides guidance for treatment planning and reducing muscle contractions in the clinical application of H-FIRE.

Irreversible electroporation, as a nonthermal therapy of prostate cancer, has been used in clinic for several years. The mechanism of irreversible electroporation ablation is thermal independent; thus, the main structures (eg, rectum, urethra, and neurovascular bundle) in prostate are spared during the treatment, which leads to the retention of prostate function. However, various clinical trials have shown that muscle contractions occur during this therapy, which warrants deep muscle anesthesia. Use of high-frequency bipolar pulses has been proposed to reduce muscle contractions during treatment, which has already triggered a multitude of studies at the cellular and animal scale. In this study, we first investigated the efficacy and safety of high-frequency bipolar pulses in human prostate cancer ablation. There are 40 male patients with prostate cancer aged between 51 and 85 years involved in this study. All patients received 250 high-frequency bipolar pulse bursts with the repeat frequency of 1 Hz. Each burst comprised 20 individual pulses of 5 microseconds, so one burst total energized time was 100 microseconds. The number of the electrodes ranged 2 to 6, depending on tumor size. A small amount of muscle relaxant was still needed, so there were no visible muscle contractions during the pulse delivery process. Four weeks after treatment, it was found that the ablation margins were distinct in magnetic resonance imaging scans, and the prostate capsule and urethra were retained. Eight patients underwent radical prostatectomy for pathological analysis after treatment, and the results of hematoxylin and eosin staining revealed that the urethra and major vasculature in prostate have been preserved. By overlaying the electric field contour on the ablation zone, the electric field lethality threshold is determined to be 522 ± 74 V/cm. This study is the first to validate the feasibility of tumor ablation by high-frequency bipolar pulses and provide valuable experience of irreversible electroporation in clinical applications.

For irreversible-electroporation (IRE)-based therapies, the underlying electric field distribution in the target tissue is influenced by the electroporation-induced conductivity changes and is important for predicting the treatment zone. Objective: In this study, we characterized the liver tissue conductivity changes during high-frequency irreversible electroporation (H-FIRE) treatments of widths 5 and 10 μs and proposed a method for predicting the ablation zones. Methods: To achieve this, we created a finite-element model of the tissue treated with H-FIRE and IRE pulses based on experiments conducted in an in-vivo rabbit liver study. We performed a parametric sweep on a Heaviside function that captured the tissue conductivity versus electric field behavior to yield a model current close to the experimental current during the first burst/pulse. A temperature module was added to account for the current increase in subsequent bursts/pulses. The evolution of the electric field at the end of the treatment was overlaid on the experimental ablation zones determined from hematoxylin and eosin staining to find the field thresholds of ablation. Results: Dynamic conductivity curves that provided a statistically significant relation between the model and experimental results were determined for H-FIRE. In addition, the field thresholds of ablation were obtained for the tested H-FIRE parameters. Conclusion: The proposed numerical model can simulate the electroporation process during H-FIRE. Significance: The treatment planning method developed in this study can be translated to H-FIRE treatments of different widths and for different tissue types.

High-frequency bipolar high-voltage pulsed electric field can be used in tumor ablation to uniform the electric field distribution in the ablated region and inhibit muscle contraction effectively. Developing a high-frequency bipolar pulsed power generator (HBPPG) with wide range of specifications such as voltage magnitude, waveform, repetition rate and pulse width, is of great significance for promoting the clinical application of irreversible electroporation. Hence, in this study, a novel modular high-voltage HBPPG circuit topology is proposed for such application. Each module consists of an H-bridge and an isolated inductor. Theoretical analysis, simulation and experimental results show that this generator perfectly combines the advantages of solid-state Marx and bridge circuit, with high stability and redundancy. The pulse frequency, pulse duration and waveform can be flexibly adjusted by controller software algorithm according to load parameters. The viability of the proposed HBPPG is demonstrated by PSpice simulation and equal-scale prototype. The key parameters of the developed HBPPG show as following: voltage amplitude up to ±10 kV with 500 ns-5 μs pulse widths, 500 kHz within the burst and 10 kHz within the continuation limited by the input high-voltage DC power supply. All the pulse parameters can be programmed arbitrarily.

Transformer winding deformation is common among all sorts of transformer failures. Cumulative deformation can eventually burgeon into catastrophic faults and result in entire network outage. It is possible to detect the early signs of faults with continuous online monitoring transformer. However, frequency response analysis (FRA) is considered to be a useful and accurate tool for sufficient detection. This paper aims at proposing a novel diagnostic system for online monitoring power transformer winding deformation based on FRA. In order to realize online monitoring transformer winding, the system uses the capacitive coupling method to inject controllable nanosecond pulses, which function as the excitation signal of winding, and to obtain the response signal. This proposed method may extend frequency range for analysis and perhaps could early detect minor winding movement and looseness. Transformer experiments show great prospect in the application of the system.