High-frequency bipolar high-voltage pulsed electric field can be used in tumor ablation to uniform the electric field distribution in the ablated region and inhibit muscle contraction effectively. Developing a high-frequency bipolar pulsed power generator (HBPPG) with wide range of specifications such as voltage magnitude, waveform, repetition rate and pulse width, is of great significance for promoting the clinical application of irreversible electroporation. Hence, in this study, a novel modular high-voltage HBPPG circuit topology is proposed for such application. Each module consists of an H-bridge and an isolated inductor. Theoretical analysis, simulation and experimental results show that this generator perfectly combines the advantages of solid-state Marx and bridge circuit, with high stability and redundancy. The pulse frequency, pulse duration and waveform can be flexibly adjusted by controller software algorithm according to load parameters. The viability of the proposed HBPPG is demonstrated by PSpice simulation and equal-scale prototype. The key parameters of the developed HBPPG show as following: voltage amplitude up to ±10 kV with 500 ns-5 μs pulse widths, 500 kHz within the burst and 10 kHz within the continuation limited by the input high-voltage DC power supply. All the pulse parameters can be programmed arbitrarily.

In order to solve problems, such as the nonadjustable drive pulsewidth of semiconductor lasers, in this article, an all-solid-state modular pulse current generator (PCG) topology based on a coupling inductor is proposed. Each stage of the PCG consists of one inductor, two switches, and a diode. The inductors are charged in series and discharged parallel to the load by controlling the timing. The design of the coupling inductor makes it possible to increase the energy storage density of the system. To reduce the requirement for a high-voltage power supply, the capacitor is first charged by the dc power supply, and then charge the energy storage inductor. Theoretical analysis, simulation, and prototype development verify the correctness and feasibility of the PCG. A seven-stage PCG prototype is developed: at a charging voltage of 0–500 V, an adjustable output of 0–200 A is achieved. The maximum pulsewidth can reach 5 μ s with a rise time and fall time of 100 ns at resistive–capacitive load. The repetition frequency can reach 100 Hz. Finally, the PCG is successfully applied to laser arrays.

This article presents a new type of all solid state boost Marx pulse generator. On the basis of the classic pulse forming Marx circuit, without changing the voltage level of each voltage module, a new switch is added for the isolated inductor energy storage and recovery, so as to realize the output of high-voltage nanosecond pulses. At the same time, in order to improve the voltage level of the semiconductor switch and break the limitation of the voltage of the single-stage pulse forming circuit, a series-connected silicon carbide (SiC) metal-oxide-semiconductor field effect transistor ( mosfet s) with a single external driver is designed. The series switch has a simple structure with few components and is extremely easy to use in a modular high voltage pulse generator. Its theoretical feasibility is verified by mathematical model and circuit simulation, and the ten-stage prototype is built in this article. Under the condition of input dc voltage of 500 V, it can output 18 kV high voltage pulses of 200–1200 ns, and the gain multiple has reached 36 times.

In recent years, pulsed magnetic field (PMF) have attracted significant attention as a non-invasive electroporation method in the biomedical field. To further explore the biomedical effects generated by oscillating PMF, we designed a novel PMF generator for biomedical research. Based on resonance principles, the designed generator outputs sinusoidal oscillating PMF. To validate the feasibility and application value of the designed topology, a miniaturized platform was constructed using a selected multi-turn solenoid coil. The output performance of the generator was tested under different discharge voltage levels. The results revealed that the current multiplication factor remained consistently around 2 times, with the energy efficiency and circuit quality factor maintained at 82% and above 4.5, respectively. In addition, the generator’s ability to flexibly modulate the number of pulse oscillations was demonstrated. The compatibility of the designed coil parameters and generator circuit parameters was analyzed, with tests on the effects of coil resistance and switch action time on the generator’s output performance. Based on the magnetic field action platform, a simulation model of the actual scale coil was established. The spatial and temporal distribution of the magnetic field, induced electric field, and power transmission in the target area were described from multiple angles. Finally, biological experiments conducted using the constructed generator revealed the synergistic effect of sinusoidal oscillating PMF combined with drugs in tumor cell killing.

Marx circuit is widely used in pulse-generating devices. However, in practical applications, the discharge loop of the Marx often includes stray capacitance and inductance, which can cause oscillations at the leading edge of the pulse. This article proposes an resistor-capacitor-diode (RCD) snubber circuit connected to the load in parallel to suppress waveform oscillations. First, the design of the RCD snubber circuit for the Marx pulse generator is presented, including the derivation of the equivalent circuit and characteristic equations. Next, the root locus method is applied to the analyzed parameters of the snubber circuit, determining the appropriate ranges of capacitance and resistance values for the RCD. Additionally, PSPICE simulation software is employed to verify the pulse oscillation suppression effectiveness of the RCD snubber circuit. Finally, the performance of the proposed RCD snubber circuit is tested on a Marx generator with 4 kV output voltage, 1 Hz frequency, and 500 ns pulsewidth. The test results demonstrate that the RCD snubber circuit has a great effect of oscillation suppression, which decreases the pules overshoot from 685 to 207 V, achieving a 69.8% reduction.