The acetone content in the exhaled breath of individuals as a biomarker of diabetes has become widely studied as a non-invasive means of quantifying blood glucose levels. This calls for development of sensors for the quantitative analysis of trace concentration of acetone, which is presents in the human exhaled breath. Traditional gas detection systems, such as the Gas Chromatography/Mass Spectrometry and several types of chemiresistive sensors are currently being used for this purpose. However, these systems are known to have limitations of size, cost, response time, operating conditions, and consistent accuracy. An ideal breath acetone sensor should provide solutions to overcome the above limitations and provide good stability and reliability. It should be a simple and portable detection system of good sensitivity, selectivity that is low in terms of both cost and power consumption. To achieve this goal, in this paper, we report a new sensing nanomaterial made by nanocomposite, 1D KWO (K₂W₇O₂₂) nanorods/2D Ti₃C₂T_x nanosheets, as the key component to design an acetone sensor. The preliminary result exhibits that the new nanocomposite has an improved response to acetone, with 10 times higher sensitivity comparing to KWO-based sensor, much better tolerance of humidity interference and enhanced stability for multiple months. By comparing with other nanomaterials: Ti₃C₂, KWO, and KWO/Ti₃C₂T_x nanocomposites with variable ratio of KWO and Ti₃C₂T_x from 1:1, 1:2, 1:5, 2:1, 4:1, and 9:1, the initial results confirm the potential of the novel KWO/Ti₃C₂ (2:1) nanocomposite to be an excellent sensing material for application in sensitive and selective detection of breath acetone for diabetics health care and prevention.