Heart Rate Variability (HRV) evaluates the autonomic nervous system regulation and can be used as a monitoring tool in conditions such as cardiovascular diseases, neuropathies and sleep staging. It can be extracted from the electrocardiogram (ECG) and the photoplethysmogram (PPG) signals. Typically, the HRV is obtained from the ECG processing. Being the PPG sensor widely used in clinical setups for physiological parameters monitoring such as blood oxygenation and ventilatory rate, the question arises regarding the PPG adequacy for HRV extraction. There is not a consensus regarding the PPG being able to replace the ECG in the HRV estimation. This work aims to be a contribution to this research area by comparing the HRV estimation obtained from simultaneously acquired ECG and PPG signals from forty subjects. A peak detection method is herein introduced based on the Hilbert transform: Hilbert Double Envelope Method (HDEM). Two other peak detector methods were also evaluated: Pan-Tompkins and Wavelet-based. HRV parameters for time, frequency and the non-linear domain were calculated for each algorithm and the Pearson correlation, T-test and RMSE were evaluated. The HDEM algorithm showed the best overall results with a sensitivity of 99.07% and 99.45% for the ECG and the PPG signals, respectively. For this algorithm, a high correlation and no significant differences were found between HRV features and the gold standard, for the ECG and PPG signals. The results show that the PPG is a suitable alternative to the ECG for HRV feature extraction.

Photoplethysmography (PPG) is widely used in wearable devices due to its conveniency and cost-effective nature. From this signal, several biomarkers can be collected, such as heart and respiration rate. For the usual acquisition scenarios, PPG is an artefact-ridden signal, which mandates the need for the designated classification algorithms to be able to reduce the noise component effect on the classification. Within the selected classification algorithm, the hyperparameters’ adjustment is of utmost importance. This study aimed to develop a deep learning model for robust PPG wave detection, which includes finding each beat’s temporal limits, from which the peak can be determined. A study database consisting of 1100 records was created from experimental PPG measurements performed in 47 participants. Different deep learning models were implemented to classify the PPG: Long Short-Term Memory (LSTM), Bidirectional LSTM, and Convolutional Neural Network (CNN). The Bidirectional LSTM and the CNN-LSTM were investigated, using the PPG Synchrosqueezed Fourier Transform (SSFT) as the models’ input. Accuracy, precision, recall, and F1-score were evaluated for all models. The CNN-LSTM algorithm, with an SSFT input, was the best performing model with accuracy, precision, and recall of 0.894, 0.923, and 0.914, respectively. This model has shown to be competent in PPG detection and delineation tasks, under noise-corrupted signals, which justifies the use of this innovative approach.

Electrohysterography (EHG) is a promising technique for pregnancy monitoring and preterm risk evaluation. It allows for uterine contraction monitoring as early as the 20th gestational week, and it is a non-invasive technique based on recording the electric signal of the uterine muscle activity from electrodes located in the abdominal surface. In this work, EHG-based contraction detection methodologies are applied using signal envelope features. Automatic contraction detection is an important step for the development of unsupervised pregnancy monitoring systems based on EHG. The exploratory methodologies include wavelet energy, Teager energy, root mean square (RMS), squared RMS, and Hilbert envelope. In this work, two main features were evaluated: contraction detection and its related delineation accuracy. The squared RMS produced the best contraction (97.15 ± 4.66%) and delineation (89.43 ± 8.10%) accuracy and the lowest false positive rate (0.63%). Despite the wavelet energy method having a contraction accuracy (92.28%) below the first-rated method, its standard deviation was the second best (6.66%). The average false positive rate ranged between 0.63% and 4.74%—a remarkably low value.

The uterine electromyogram, also called electrohysterogram (EHG), is the electrical signal generated by uterine contractile activity. The EHG has been considered an expanding technique for pregnancy monitoring and preterm risk evaluation. Data were collected on the abdominal surface. It has been speculated the effect of the placenta location on the characteristics of the EHG. In this work, a preliminary exploration method is proposed using the average spectra of Alvarez waves contractions of subjects with anterior and non-anterior placental position as a basis for the triple-dispersion Cole model that provides a best fit for these two cases. This leads to the uterine impedance estimation for these two study cases. Non-linear least square fitting (NLSF) was applied for this modelling process, which produces electric circuit fractional models’ representations. A triple-dispersion Cole-impedance model was used to obtain the uterine impedance curve in a frequency band between 0.1 and 1 Hz. A proposal for the interpretation relating the model parameters and the placental influence on the myometrial contractile action is provided. This is the first report regarding in silico estimation of the uterine impedance for cases involving anterior or non-anterior placental positions.

The electrohysterogram (EHG) is the uterine muscle electromyogram recorded at the abdominal surface of pregnant or non-pregnant woman. The maternal respiration electromyographic signal (MR-EMG) is one of the most relevant interferences present in an EHG. Alvarez (Alv) waves are components of the EHG that have been indicated as having the potential for preterm and term birth prediction. The MR-EMG component in the EHG represents an issue, regarding Alv wave application for pregnancy monitoring, for instance, in preterm birth prediction, a subject of great research interest. Therefore, the Alv waves denoising method should be designed to include the interference MR-EMG attenuation, without compromising the original waves. Adaptive filter properties make them suitable for this task. However, selecting the optimal adaptive filter and its parameters is an important task for the success of the filtering operation. In this work, an algorithm is presented for the automatic adaptive filter and parameter selection using synthetic data. The filter selection pool comprised sixteen candidates, from which, the Wiener, recursive least squares (RLS), householder recursive least squares (HRLS), and QR-decomposition recursive least squares (QRD-RLS) were the best performers. The optimized parameters were L = 2 (filter length) for all of them and λ = 1 (forgetting factor) for the last three. The developed optimization algorithm may be of interest to other applications. The optimized filters were applied to real data. The result was the attenuation of the MR-EMG in Alv waves power. For the Wiener filter, power reductions for quartile 1, median, and quartile 3 were found to be −16.74%, −20.32%, and −15.78%, respectively (p-value = 1.31 × 10⁻¹²).