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Age-related macular degeneration (AMD) is one of the main causes of deterioration in vision in adults aged 55 and older. In spite of therapies, the progression of the disease is often observed without reverse vision quality. In the present study, we explored whether, in undifferentiated ARPE-19 retinal cells, a disruption of the VEGF receptors (VEGF-R)/caveolin-1 (Cav-1)/protein kinases pathway could be a target for counteracting VEGF secretion. We highlight that Resvega®, a combination of omega-3 fatty acids with an antioxidant, resveratrol, inhibits VEGF-A secretion in vitro by disrupting the dissociation of the VEGF-R2/Cav-1 complex into rafts and subsequently preventing MAPK activation. Moreover, DNA ChIP analysis reveals that this combination prevents the interaction between AP-1 and vegf-a and vegf-r2 gene promoters. By these pathways, Resvega could present a potential interest as nutritional complementation against AMD.
Flavie Courtaut; Alessandra Scagliarini; Virginie Aires; Clarisse Cornebise; Jean-Paul Pais de Barros; Céline Olmiere; Dominique Delmas. VEGF-R2/Caveolin-1 Pathway of Undifferentiated ARPE-19 Retina Cells: A Potential Target as Anti-VEGF-A Therapy in Wet AMD by Resvega, an Omega-3/Polyphenol Combination. International Journal of Molecular Sciences 2021, 22, 6590 .
AMA StyleFlavie Courtaut, Alessandra Scagliarini, Virginie Aires, Clarisse Cornebise, Jean-Paul Pais de Barros, Céline Olmiere, Dominique Delmas. VEGF-R2/Caveolin-1 Pathway of Undifferentiated ARPE-19 Retina Cells: A Potential Target as Anti-VEGF-A Therapy in Wet AMD by Resvega, an Omega-3/Polyphenol Combination. International Journal of Molecular Sciences. 2021; 22 (12):6590.
Chicago/Turabian StyleFlavie Courtaut; Alessandra Scagliarini; Virginie Aires; Clarisse Cornebise; Jean-Paul Pais de Barros; Céline Olmiere; Dominique Delmas. 2021. "VEGF-R2/Caveolin-1 Pathway of Undifferentiated ARPE-19 Retina Cells: A Potential Target as Anti-VEGF-A Therapy in Wet AMD by Resvega, an Omega-3/Polyphenol Combination." International Journal of Molecular Sciences 22, no. 12: 6590.
The multidrug resistance phenotype is a global phenomenon and causes chemotherapy failure in various cancers, such as in uterine sarcomas that have a high mortality rate. To overcome this phenotype, there is growing research interest in developing new treatment strategies. In this study, we highlight the potential of two essential oils from the Apiaceae family, Pituranthos chloranthus (PC) and Teucrium ramosissimum Desf. (TR), to act as chemopreventive and chemosensitizing agents against two uterine sarcoma cell lines, MES-SA and P-gp-overexpressing MES-SA/Dx5 cells. We found that PC and TR were able to inhibit the cell viability of sensitive MES-SA and resistant MES-SA/Dx5 cells by a slight modulation of the cell cycle and its regulators, but also through a significant induction of apoptosis. The molecular mechanism involved both caspase pathways associated with an overproduction of reactive oxygen species (ROS) and mitochondrial membrane depolarization. Very interestingly, the combination of doxorubicin with PC or TR induced a synergism to increase cell death in resistant MES-SA/Dx5 cells and, subsequently, had the benefit of decreasing the resistance index to doxorubicin. These synergistic effects were reinforced by a decrease in P-gp expression and its P-gp adenosine triphosphatase (ATPase) activity, which subsequently led to intracellular doxorubicin accumulation in resistant sarcoma cells.
Aida Lahmar; Aline Mathey; Virginie Aires; Dorra Elgueder; Anne Vejux; Rihab Khlifi; Fairouz Sioud; Leila Chekir-Ghedira; Dominique Delmas. Essential Oils, Pituranthos chloranthus and Teucrium ramosissimum, Chemosensitize Resistant Human Uterine Sarcoma MES-SA/Dx5 Cells to Doxorubicin by Inducing Apoptosis and Targeting P-Glycoprotein. Nutrients 2021, 13, 1719 .
AMA StyleAida Lahmar, Aline Mathey, Virginie Aires, Dorra Elgueder, Anne Vejux, Rihab Khlifi, Fairouz Sioud, Leila Chekir-Ghedira, Dominique Delmas. Essential Oils, Pituranthos chloranthus and Teucrium ramosissimum, Chemosensitize Resistant Human Uterine Sarcoma MES-SA/Dx5 Cells to Doxorubicin by Inducing Apoptosis and Targeting P-Glycoprotein. Nutrients. 2021; 13 (5):1719.
Chicago/Turabian StyleAida Lahmar; Aline Mathey; Virginie Aires; Dorra Elgueder; Anne Vejux; Rihab Khlifi; Fairouz Sioud; Leila Chekir-Ghedira; Dominique Delmas. 2021. "Essential Oils, Pituranthos chloranthus and Teucrium ramosissimum, Chemosensitize Resistant Human Uterine Sarcoma MES-SA/Dx5 Cells to Doxorubicin by Inducing Apoptosis and Targeting P-Glycoprotein." Nutrients 13, no. 5: 1719.
Eye diseases are currently a major public health concern due to the growing number of cases resulting from both an aging of populations and exogenous factors linked to our lifestyles. Thus, many treatments including surgical pharmacological approaches have emerged, and special attention has been paid to prevention, where diet plays a preponderant role. Recently, potential antioxidants such as resveratrol have received much attention as potential tools against various ocular diseases. In this review, we focus on the mechanisms of resveratrol against ocular diseases, in particular age-related macular degeneration, glaucoma, cataract, diabetic retinopathy, and vitreoretinopathy. We analyze, in relation to the different steps of each disease, the resveratrol properties at multiple levels, such as cellular and molecular signaling as well as physiological effects. We show and discuss the relationship to reactive oxygen species, the regulation of inflammatory process, and how resveratrol can prevent ocular diseases through a potential epigenetic action by the activation of sirtuin-1. Lastly, various new forms of resveratrol delivery are emerging at the same time as some clinical trials are raising more questions about the future of resveratrol as a potential tool for prevention or in therapeutic strategies against ocular diseases. More preclinical studies are required to provide further insights into RSV’s potential adjuvant activity.
Dominique Delmas; Clarisse Cornebise; Flavie Courtaut; Jianbo Xiao; Virginie Aires. New Highlights of Resveratrol: A Review of Properties against Ocular Diseases. International Journal of Molecular Sciences 2021, 22, 1295 .
AMA StyleDominique Delmas, Clarisse Cornebise, Flavie Courtaut, Jianbo Xiao, Virginie Aires. New Highlights of Resveratrol: A Review of Properties against Ocular Diseases. International Journal of Molecular Sciences. 2021; 22 (3):1295.
Chicago/Turabian StyleDominique Delmas; Clarisse Cornebise; Flavie Courtaut; Jianbo Xiao; Virginie Aires. 2021. "New Highlights of Resveratrol: A Review of Properties against Ocular Diseases." International Journal of Molecular Sciences 22, no. 3: 1295.
Age-related macular degeneration (AMD) is a degenerative disease of the retina where the molecular mechanism involves the production of vascular endothelial growth factor (VEGF), a factor of poor prognosis of the progression of the disease. Previous studies have shown that resveratrol, a polyphenol of grapevines, can prevent VEGF secretion induced by stress from retinal cells. Considering the fundamental role played by VEGF in development and progression of AMD, we investigate the potential effect of red wine extract (RWE) on VEGF secretion and its signaling pathway in human retinal cells ARPE-19. To examine the effect of RWE in ARPE-19, a quantitative and qualitative analysis of the RWE was performed by HPLC MS/MS. We show for the first time that RWE decreased VEGF-A secretion from ARPE-19 cells and its protein expression in concentration-dependent manner. RWE-induced alteration in VEGF-A production is associated with a down of VEGF-receptor 2 (VEGF-R2) protein expression and its phosphorylated intracytoplasmic domain. Subsequently, the activation of kinase pathway is disturbing and RWE prevents the phosphorylation of MEK and ERK 1/2 in human retinal cells ARPE-19. Finally, this study sheds light on the interest that the use of polyphenolic cocktails could represent in a prevention strategy.
Clarisse Cornebise; Flavie Courtaut; Marie Taillandier-Coindard; Josep Valls-Fonayet; Tristan Richard; David Monchaud; Virginie Aires; Dominique Delmas. Red Wine Extract Inhibits VEGF Secretion and Its Signaling Pathway in Retinal ARPE-19 Cells to Potentially Disrupt AMD. Molecules 2020, 25, 5564 .
AMA StyleClarisse Cornebise, Flavie Courtaut, Marie Taillandier-Coindard, Josep Valls-Fonayet, Tristan Richard, David Monchaud, Virginie Aires, Dominique Delmas. Red Wine Extract Inhibits VEGF Secretion and Its Signaling Pathway in Retinal ARPE-19 Cells to Potentially Disrupt AMD. Molecules. 2020; 25 (23):5564.
Chicago/Turabian StyleClarisse Cornebise; Flavie Courtaut; Marie Taillandier-Coindard; Josep Valls-Fonayet; Tristan Richard; David Monchaud; Virginie Aires; Dominique Delmas. 2020. "Red Wine Extract Inhibits VEGF Secretion and Its Signaling Pathway in Retinal ARPE-19 Cells to Potentially Disrupt AMD." Molecules 25, no. 23: 5564.
Silymarin extracted from milk thistle consisting of flavonolignan silybin has shown chemopreventive and chemosensitizing activity against various cancers. The present review summarizes the current knowledge on the potential targets of silymarin against various cancers. Silymarin may play on the system of xenobiotics, metabolizing enzymes (phase I and phase II) to protect normal cells against various toxic molecules or to protect against deleterious effects of chemotherapeutic agents on normal cells. Furthermore, silymarin and its main bioactive compounds inhibit organic anion transporters (OAT) and ATP-binding cassettes (ABC) transporters, thus contributing to counteracting potential chemoresistance. Silymarin and its derivatives play a double role, namely, limiting the progression of cancer cells through different phases of the cycle—thus forcing them to evolve towards a process of cell death—and accumulating cancer cells in a phase of the cell cycle—thus making it possible to target a greater number of tumor cells with a specific anticancer agent. Silymarin exerts a chemopreventive effect by inducing intrinsic and extrinsic pathways and reactivating cell death pathways by modulation of the ratio of proapoptotic/antiapoptotic proteins and synergizing with agonists of death domains receptors. In summary, we highlight how silymarin may act as a chemopreventive agent and a chemosensitizer through multiple pathways.
Dominique Delmas; Jianbo Xiao; Anne Vejux; Virginie Aires. Silymarin and Cancer: A Dual Strategy in Both in Chemoprevention and Chemosensitivity. Molecules 2020, 25, 2009 .
AMA StyleDominique Delmas, Jianbo Xiao, Anne Vejux, Virginie Aires. Silymarin and Cancer: A Dual Strategy in Both in Chemoprevention and Chemosensitivity. Molecules. 2020; 25 (9):2009.
Chicago/Turabian StyleDominique Delmas; Jianbo Xiao; Anne Vejux; Virginie Aires. 2020. "Silymarin and Cancer: A Dual Strategy in Both in Chemoprevention and Chemosensitivity." Molecules 25, no. 9: 2009.
In spite of chemotherapy and systematic screening for people at risk, the mortality rate of colorectal cancer (CRC) remains consistently high, with 600,000 deaths per year. This low success rate in the treatment of CRC results from many failures associated with high resistance and the risk of metastasis. Therefore, in response to these therapeutic failures, new strategies have been under development for several years aimed at increasing the effect of anticancer compounds and/or at reducing their secondary effects on normal cells, thus enabling the host to better withstand chemotherapy. This study highlights that xanthohumol (Xn) concentrations under the IC50 values were able to induce apoptosis and to enhance the DNA-damage response (DDR). We demonstrate for the first time that Xn exerts its anticancer activity in models of colon cancer through activation of the ataxia telangiectasia mutated (ATM) pathway. Subsequently, the ability of Xn to restore DNA damage in CRC cells can sensitize them to anticancer agents such as SN38 (7-ethyl-10-hydroxycamptothecin) used in chemotherapy.
Alessandra Scagliarini; Aline Mathey; Virginie Aires; Dominique Delmas. Xanthohumol, a Prenylated Flavonoid from Hops, Induces DNA Damages in Colorectal Cancer Cells and Sensitizes SW480 Cells to the SN38 Chemotherapeutic Agent. Cells 2020, 9, 932 .
AMA StyleAlessandra Scagliarini, Aline Mathey, Virginie Aires, Dominique Delmas. Xanthohumol, a Prenylated Flavonoid from Hops, Induces DNA Damages in Colorectal Cancer Cells and Sensitizes SW480 Cells to the SN38 Chemotherapeutic Agent. Cells. 2020; 9 (4):932.
Chicago/Turabian StyleAlessandra Scagliarini; Aline Mathey; Virginie Aires; Dominique Delmas. 2020. "Xanthohumol, a Prenylated Flavonoid from Hops, Induces DNA Damages in Colorectal Cancer Cells and Sensitizes SW480 Cells to the SN38 Chemotherapeutic Agent." Cells 9, no. 4: 932.
Despite major advances in the last 10 years, whether in terms of prevention or treatment, the 5 year survival rate remains relatively low for a large number of cancers. These therapeutic failures can be the consequence of several factors associated with the cellular modifications or with the host by itself, especially for some anticancer drugs such as cisplatin, which induces a nephrotoxicity. In the strategy of research for active molecules capable both of exerting a protective action against the deleterious effects of cisplatin and exerting a chemosensitizing action with regard to cancer cells, we tested the potential effects of Ephedra alata Decne extract (E.A.) rich in polyphenolic compounds towards a 4T1 breast cancer model in vitro and in vivo. We showed that E.A. extract inhibited cell viability of 4T1 breast cancer cells and induced apoptosis in a caspase-dependent manner, which involved intrinsic pathways. Very interestingly, we observed a synergic antiproliferative and pro-apoptotic action with cisplatin. These events were associated with a strong decrease of breast tumor growth in mice treated with an E.A./cisplatin combination and simultaneously with a decrease of hepato- and nephrotoxicities of cisplatin.
Fairouz Sioud; Souheila Amor; Imène Ben Toumia; Aida Lahmar; Virginie Aires; Leila Chekir-Ghedira; Dominique Delmas. A New Highlight of Ephedra alata Decne Properties as Potential Adjuvant in Combination with Cisplatin to Induce Cell Death of 4T1 Breast Cancer Cells In Vitro and In Vivo. Cells 2020, 9, 362 .
AMA StyleFairouz Sioud, Souheila Amor, Imène Ben Toumia, Aida Lahmar, Virginie Aires, Leila Chekir-Ghedira, Dominique Delmas. A New Highlight of Ephedra alata Decne Properties as Potential Adjuvant in Combination with Cisplatin to Induce Cell Death of 4T1 Breast Cancer Cells In Vitro and In Vivo. Cells. 2020; 9 (2):362.
Chicago/Turabian StyleFairouz Sioud; Souheila Amor; Imène Ben Toumia; Aida Lahmar; Virginie Aires; Leila Chekir-Ghedira; Dominique Delmas. 2020. "A New Highlight of Ephedra alata Decne Properties as Potential Adjuvant in Combination with Cisplatin to Induce Cell Death of 4T1 Breast Cancer Cells In Vitro and In Vivo." Cells 9, no. 2: 362.
Resveratrol has been proposed to prevent tumor growth and the different steps of carcinogenesis; nevertheless, these biological effects are sometimes discordant between different cell types. Several hypotheses and works have suggested that the metabolism of resveratrol could be at the origin of a different cellular response. We show here, using colorectal tumor cell lines, that the biological effects of RSV result mainly from its carriage by carriers of the superfamily of ABC transporter, i.e., P-gP, MRP, or BCRP. Using cell lines overexpressing these different transporters, we have been able to highlight the importance of P-gP in the response of cells to RSV. These results were confirmed by invalidating the gene coding for P-gP, which restored the sensitivity of colorectal cells resistant to the polyphenol. Subsequently, the status of P-glycoprotein expression is an important element to be taken into consideration in the cytotoxic activity of resveratrol in colorectal cancer cells.
Virginie Aires; Didier J Colin; Agnès Doreau; Attilio Di Pietro; Jean-Marie Heydel; Yves Artur; Norbert Latruffe; Dominique Delmas. P-Glycoprotein 1 Affects Chemoactivities of Resveratrol against Human Colorectal Cancer Cells. Nutrients 2019, 11, 2098 .
AMA StyleVirginie Aires, Didier J Colin, Agnès Doreau, Attilio Di Pietro, Jean-Marie Heydel, Yves Artur, Norbert Latruffe, Dominique Delmas. P-Glycoprotein 1 Affects Chemoactivities of Resveratrol against Human Colorectal Cancer Cells. Nutrients. 2019; 11 (9):2098.
Chicago/Turabian StyleVirginie Aires; Didier J Colin; Agnès Doreau; Attilio Di Pietro; Jean-Marie Heydel; Yves Artur; Norbert Latruffe; Dominique Delmas. 2019. "P-Glycoprotein 1 Affects Chemoactivities of Resveratrol against Human Colorectal Cancer Cells." Nutrients 11, no. 9: 2098.
Obesity may not be consistently associated with metabolic disorders and mortality later in life, prompting exploration of the challenging concept of healthy obesity. Here, the consumption of a high-fat/high-sucrose (HF/HS) diet produces hyperglycaemia and hypercholesterolaemia, increases oxidative stress, increases endotoxaemia, expands adipose tissue (with enlarged adipocytes, enhanced macrophage infiltration and the accumulation of cholesterol and oxysterols), and reduces the median lifespan of obese mice. Despite the persistence of obesity, supplementation with a polyphenol-rich plant extract (PRPE) improves plasma lipid levels and endotoxaemia, prevents macrophage recruitment to adipose tissues, reduces adipose accumulation of cholesterol and cholesterol oxides, and extends the median lifespan. PRPE drives the normalization of the HF/HS-mediated functional enrichment of genes associated with immunity and inflammation (in particular the response to lipopolysaccharides). The long-term limitation of immune cell infiltration in adipose tissue by PRPE increases the lifespan through a mechanism independent of body weight and fat storage and constitutes the hallmark of a healthy adiposity trait.
Virginie Aires; Jérôme Labbé; Valérie Deckert; Jean-Paul Pais De Barros; Romain Boidot; Marc Haumont; Guillaume Maquart; Naig Le Guern; David Masson; Emmanuelle Prost-Camus; Michel Prost; Laurent Lagrost. Healthy adiposity and extended lifespan in obese mice fed a diet supplemented with a polyphenol-rich plant extract. Scientific Reports 2019, 9, 1 -16.
AMA StyleVirginie Aires, Jérôme Labbé, Valérie Deckert, Jean-Paul Pais De Barros, Romain Boidot, Marc Haumont, Guillaume Maquart, Naig Le Guern, David Masson, Emmanuelle Prost-Camus, Michel Prost, Laurent Lagrost. Healthy adiposity and extended lifespan in obese mice fed a diet supplemented with a polyphenol-rich plant extract. Scientific Reports. 2019; 9 (1):1-16.
Chicago/Turabian StyleVirginie Aires; Jérôme Labbé; Valérie Deckert; Jean-Paul Pais De Barros; Romain Boidot; Marc Haumont; Guillaume Maquart; Naig Le Guern; David Masson; Emmanuelle Prost-Camus; Michel Prost; Laurent Lagrost. 2019. "Healthy adiposity and extended lifespan in obese mice fed a diet supplemented with a polyphenol-rich plant extract." Scientific Reports 9, no. 1: 1-16.
The mitochondrial-located enzyme Carnitine palmitoyltransferase
Virginie Aires; Dominique Delmas; Fatima Djouadi; Jean Bastin; Mustapha Cherkaoui; Norbert Latruffe. Resveratrol-Dependent Stimulation of Mitochondrial Fatty Acid Oxidation in Deficient Cells. Implication of miRNAs. Proceedings 2019, 11, 5 .
AMA StyleVirginie Aires, Dominique Delmas, Fatima Djouadi, Jean Bastin, Mustapha Cherkaoui, Norbert Latruffe. Resveratrol-Dependent Stimulation of Mitochondrial Fatty Acid Oxidation in Deficient Cells. Implication of miRNAs. Proceedings. 2019; 11 (1):5.
Chicago/Turabian StyleVirginie Aires; Dominique Delmas; Fatima Djouadi; Jean Bastin; Mustapha Cherkaoui; Norbert Latruffe. 2019. "Resveratrol-Dependent Stimulation of Mitochondrial Fatty Acid Oxidation in Deficient Cells. Implication of miRNAs." Proceedings 11, no. 1: 5.
Inflammation has been described as an initiator event of major diseases with significant impacts in terms of public health including in cardiovascular disease, autoimmune disorders, eye diseases, age-related diseases, and the occurrence of cancers. A preventive action to reduce the key processes leading to inflammation could be an advantageous approach to reducing these associated pathologies. Many studies have reported the value of polyphenols such as resveratrol in counteracting pro-inflammatory cytokines. We have previously shown the potential of red wine extract (RWE) and the value of its qualitative and quantitative polyphenolic composition to prevent the carcinogenesis process. In this study, we addressed a new effect of RWE in inflammation through a modulation of IL-1β secretion and the NLRP3 inflammasome pathway. NLRP3 inflammasome requires two signals, priming to increase the synthesis of NLRP3 and pro-IL-1β proteins and activation, which activates NLRP3. Inflammasome formation is triggered by a range of substances such as lipopolysaccharide (LPS). Using two different macrophages, one of which does not express the adaptor protein ASC (apoptosis-associated speck-like protein containing a CARD), which is essential to form active inflammasome complexes that produce IL-1β, we show that RWE decreases IL-1 β secretion and gene expression whatever line is used. Moreover, this strong reduction of pro-inflammatory IL-1β is associated with a decrease of NLRP3 and, in J774A, ASC protein expression, which depends on the choice of activator ATP or nigericin.
Pauline Chalons; Souheila Amor; Flavie Courtaut; Emma Cantos-Villar; Tristan Richard; Cyril Auger; Philippe Chabert; Valérie Schni-Kerth; Virginie Aires; Dominique Delmas. Study of Potential Anti-Inflammatory Effects of Red Wine Extract and Resveratrol through a Modulation of Interleukin-1-Beta in Macrophages. Nutrients 2018, 10, 1856 .
AMA StylePauline Chalons, Souheila Amor, Flavie Courtaut, Emma Cantos-Villar, Tristan Richard, Cyril Auger, Philippe Chabert, Valérie Schni-Kerth, Virginie Aires, Dominique Delmas. Study of Potential Anti-Inflammatory Effects of Red Wine Extract and Resveratrol through a Modulation of Interleukin-1-Beta in Macrophages. Nutrients. 2018; 10 (12):1856.
Chicago/Turabian StylePauline Chalons; Souheila Amor; Flavie Courtaut; Emma Cantos-Villar; Tristan Richard; Cyril Auger; Philippe Chabert; Valérie Schni-Kerth; Virginie Aires; Dominique Delmas. 2018. "Study of Potential Anti-Inflammatory Effects of Red Wine Extract and Resveratrol through a Modulation of Interleukin-1-Beta in Macrophages." Nutrients 10, no. 12: 1856.
There are compelling evidences that resveratrol act on immune systems by affecting the major type of immune cells and pro-inflammatory-cytokines associated lymphocytes. Resveratrol is able to interfere on the adaptative and innate immune responses trough a modulation of cytokine-associated immune cells, of the lymphocyte differentiation process and the ratio of the different subtypes of T lymphocytes. In this chapter, we discuss the resveratrol action on the different subtypes of immune cells and subsequently on the interleukin-associated production in various contexts of diseases (auto-immune diseases, cancers). We highlight in each case the molecular mechanism by which resveratrol modulates the immune and inflammatory response, in particular by modulating signaling pathways such as the NFκB pathway or MAPK pathways. By these immunomodulatory properties, resveratrol could provide a novel strategy to enhance the efficacy of immunotherapy in various human diseases.
Dominique Delmas; Emeric Limagne; Anne Vejux; François Ghiringhelli; Virginie Aires. A Link Between Immunity and Inflammation: Actionable Targets of Resveratrol. Resveratrol: State-of-the-Art Science and Health Applications 2018, 209 -237.
AMA StyleDominique Delmas, Emeric Limagne, Anne Vejux, François Ghiringhelli, Virginie Aires. A Link Between Immunity and Inflammation: Actionable Targets of Resveratrol. Resveratrol: State-of-the-Art Science and Health Applications. 2018; ():209-237.
Chicago/Turabian StyleDominique Delmas; Emeric Limagne; Anne Vejux; François Ghiringhelli; Virginie Aires. 2018. "A Link Between Immunity and Inflammation: Actionable Targets of Resveratrol." Resveratrol: State-of-the-Art Science and Health Applications , no. : 209-237.
Wine has been popular worldwide for many centuries and currently remains an important component of our diet. Scientific interest in wine and its health effects has grown considerably since the 1990s with the emergence of the “French Paradox” concept, correlating moderate wine consumption, a characteristic of the Mediterranean diet, and low incidence of coronary heart diseases. Since then, the positive effects on health, health promotion, disease prevention, and disease prognosis of moderate wine consumption, in particular red wine, have been attributed to its polyphenolic compounds such as resveratrol, quercetin, and other flavonoids acting as antioxidants. Several epidemiological, in vivo and in vitro, studies have reported that moderate red wine or red wine polyphenolic extract consumption may be active in the prevention and treatment of chronic diseases such as cardiovascular disease, metabolic syndrome, degenerative pathologies, and cancer. The aim of this review is to summarize the current findings about the effects of red wine polyphenols on cancer and to discuss how the polyphenolic composition of red wine may influence its chemopreventive properties.
Souheila Amor; Pauline Châlons; Virginie Aires; Dominique Delmas. Polyphenol Extracts from Red Wine and Grapevine: Potential Effects on Cancers. Diseases 2018, 6, 106 .
AMA StyleSouheila Amor, Pauline Châlons, Virginie Aires, Dominique Delmas. Polyphenol Extracts from Red Wine and Grapevine: Potential Effects on Cancers. Diseases. 2018; 6 (4):106.
Chicago/Turabian StyleSouheila Amor; Pauline Châlons; Virginie Aires; Dominique Delmas. 2018. "Polyphenol Extracts from Red Wine and Grapevine: Potential Effects on Cancers." Diseases 6, no. 4: 106.
Lipid droplets (LD) are now-well recognized as playing a role in cancer progression, however their potential role in chemoresistance remains largely unknown, particularly in colorectal cancer (CRC). We recently highlighted that LD accumulate in CRC cells under the control of lysophosphatidylcholine acyltransferase 2 (LPCAT2) enzyme expression. We also showed that chemotherapy-induced LD accumulation counteracts intrinsic and extrinsic cancer cell death activation.
Alexia Karen Cotte; Virginie Aires; François Ghiringhelli; Dominique Delmas. LPCAT2 controls chemoresistance in colorectal cancer. Molecular & Cellular Oncology 2018, 5, e1448245 .
AMA StyleAlexia Karen Cotte, Virginie Aires, François Ghiringhelli, Dominique Delmas. LPCAT2 controls chemoresistance in colorectal cancer. Molecular & Cellular Oncology. 2018; 5 (3):e1448245.
Chicago/Turabian StyleAlexia Karen Cotte; Virginie Aires; François Ghiringhelli; Dominique Delmas. 2018. "LPCAT2 controls chemoresistance in colorectal cancer." Molecular & Cellular Oncology 5, no. 3: e1448245.
Carnitine palmitoyltransferase-2 (CPT2) is a mitochondrial enzyme involved in long-chain fatty acid entry into mitochondria for their β-oxidation and energy production. Two phenotypes are associated with the extremely reduced CPT2 activity in genetically deficient patients: neonatal lethality or, in milder forms, myopathy. Resveratrol (RSV) is a phytophenol produced by grape plant in response to biotic or abiotic stresses that displays anti-oxidant properties, in particular through AP-1, NFκB, STAT-3, and COX pathways. Some beneficiary effects of RSV are due to its modulation of microRNA (miRNA) expression. RSV can enhance residual CPT2 activities in human fibroblasts derived from CPT2-deficient patients and restores normal fatty acid oxidation rates likely through stimulation of mitochondrial biogenesis. Here, we report changes in miRNA expression linked to CPT2-deficiency, and we identify miRNAs whose expression changed following RSV treatment of control or CPT2-deficient fibroblasts isolated from patients. Our findings suggest that RSV consumption might exert beneficiary effects in patients with CPT2-deficiency.
Virginie Aires; Dominique Delmas; Fatima Djouadi; Jean Bastin; Mustapha Cherkaoui-Malki; Norbert Latruffe. Resveratrol-Induced Changes in MicroRNA Expression in Primary Human Fibroblasts Harboring Carnitine-Palmitoyl Transferase-2 Gene Mutation, Leading to Fatty Acid Oxidation Deficiency. Molecules 2017, 23, 7 .
AMA StyleVirginie Aires, Dominique Delmas, Fatima Djouadi, Jean Bastin, Mustapha Cherkaoui-Malki, Norbert Latruffe. Resveratrol-Induced Changes in MicroRNA Expression in Primary Human Fibroblasts Harboring Carnitine-Palmitoyl Transferase-2 Gene Mutation, Leading to Fatty Acid Oxidation Deficiency. Molecules. 2017; 23 (1):7.
Chicago/Turabian StyleVirginie Aires; Dominique Delmas; Fatima Djouadi; Jean Bastin; Mustapha Cherkaoui-Malki; Norbert Latruffe. 2017. "Resveratrol-Induced Changes in MicroRNA Expression in Primary Human Fibroblasts Harboring Carnitine-Palmitoyl Transferase-2 Gene Mutation, Leading to Fatty Acid Oxidation Deficiency." Molecules 23, no. 1: 7.
Resveratrol (RSV) has been proposed to prevent tumor growth; nevertheless, these preventive effects are controversial since RSV pharmacokinetics studies show a low bioavailability. Recent clinical trials show that patients with colorectal cancer and receiving oral RSV have high levels of RSV conjugates in the colorectum, mainly RSV-3-O-sulfate (R3S), RSV-3-O-glucuronide, and RSV-4'-O-glucuronide. However, their potential biological activity has not yet been established. This study thus investigated in human colorectal cancer cell lines whether RSV main metabolites retain anticarcinogenic properties as their parental molecule. Proliferation, apoptosis assays and cell cycle analysis were performed to study the effect of RSV, R3S, RSV-3-O-glucuronide, or RSV-4'-O-glucuronide alone or of a mixture of the three metabolites. R3S inhibits colon cancer cells proliferation and an accumulation of cells in S phase. Interestingly, the mixture induced a synergistic effect. This process was associated with an induction of DNA damages and apoptotic process, which allowed sensitization of colon cancer cells to the anticancer drugs. Altogether, our data provide significant new insight into the molecular mechanism of RSV and support the notion that despite low bioavailability in vivo, RSV biological effects could be mediated by its metabolites.
Virginie Aires; Emeric Limagne; Alexia Cotte; Norbert Latruffe; Francois Ghiringhelli; Dominique Delmas. Resveratrol metabolites inhibit human metastatic colon cancer cells progression and synergize with chemotherapeutic drugs to induce cell death. Molecular Nutrition & Food Research 2013, 57, 1170 -1181.
AMA StyleVirginie Aires, Emeric Limagne, Alexia Cotte, Norbert Latruffe, Francois Ghiringhelli, Dominique Delmas. Resveratrol metabolites inhibit human metastatic colon cancer cells progression and synergize with chemotherapeutic drugs to induce cell death. Molecular Nutrition & Food Research. 2013; 57 (7):1170-1181.
Chicago/Turabian StyleVirginie Aires; Emeric Limagne; Alexia Cotte; Norbert Latruffe; Francois Ghiringhelli; Dominique Delmas. 2013. "Resveratrol metabolites inhibit human metastatic colon cancer cells progression and synergize with chemotherapeutic drugs to induce cell death." Molecular Nutrition & Food Research 57, no. 7: 1170-1181.