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Mercedes Gil-Campos
Metabolism and Investigation Unit, Reina Sofia University Hospital, Maimónides Institute of Biomedicine Research of Córdoba (IMIBIC), University of Córdoba, 14071 Córdoba, Spain

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Journal article
Published: 25 August 2021 in Nutrients
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The aim was to identify different dietary and physical activity (PA) patterns in 5- to 14-year-old children with a high prevalence of overweight and obesity using cluster analysis based on their adherence to the Spanish Society of Community Nutrition dietary guidelines and levels of PA, and to determine their associations with age, sex, body composition, and cardiometabolic risk markers. In 549 children, hierarchical cluster analysis was used to identify subgroups with similar adherence to dietary recommendations and level of PA. Three clusters were identified: Cluster 1, with the lowest level of vigorous PA and adherence to dietary recommendations; Cluster 2, with the lowest levels of moderate and vigorous PA and the highest adherence to dietary recommendations; and Cluster 3, with the highest level of PA, especially vigorous PA and a medium level adherence to dietary recommendations. Cluster 3 had lower total body fat and higher lean body mass percentages than Cluster 2. Cluster 2 had lower high-density lipoprotein cholesterol and higher low-density lipoprotein cholesterol levels than Cluster 1. The results from our study suggest that it is important to consider adherence to PA recommendations together with adherence to dietary guidelines to understand patterns of obesogenic habits in pediatric populations with high prevalence of overweight and obesity.

ACS Style

Mercedes Gil-Campos; Alexandra Pérez-Ferreirós; Francisco Jesús Llorente-Cantarero; Augusto Anguita-Ruiz; Juan José Bedoya-Carpente; Anton Kalén; Luis A. Moreno; Gloria Bueno; Ángel Gil; Concepción M. Aguilera; Rosaura Leis. Association of Diet, Physical Activity Guidelines and Cardiometabolic Risk Markers in Children. Nutrients 2021, 13, 2954 .

AMA Style

Mercedes Gil-Campos, Alexandra Pérez-Ferreirós, Francisco Jesús Llorente-Cantarero, Augusto Anguita-Ruiz, Juan José Bedoya-Carpente, Anton Kalén, Luis A. Moreno, Gloria Bueno, Ángel Gil, Concepción M. Aguilera, Rosaura Leis. Association of Diet, Physical Activity Guidelines and Cardiometabolic Risk Markers in Children. Nutrients. 2021; 13 (9):2954.

Chicago/Turabian Style

Mercedes Gil-Campos; Alexandra Pérez-Ferreirós; Francisco Jesús Llorente-Cantarero; Augusto Anguita-Ruiz; Juan José Bedoya-Carpente; Anton Kalén; Luis A. Moreno; Gloria Bueno; Ángel Gil; Concepción M. Aguilera; Rosaura Leis. 2021. "Association of Diet, Physical Activity Guidelines and Cardiometabolic Risk Markers in Children." Nutrients 13, no. 9: 2954.

Original research article
Published: 26 March 2021 in Frontiers in Psychiatry
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This study examined the presence of neurodevelopmental regression and its effects on the clinical manifestations and the severity of autism spectrum disorder (ASD) in a group of children with autism compared with those without neurodevelopmental regression at the time of initial classification and subsequently. Methods and Subjects: ASD patients were classified into two subgroups, neurodevelopmental regressive (AMR) and non-regressive (ANMR), using a questionnaire based on the Autism Diagnostic Interview-Revised test. The severity of ASD and neurodevelopment were assessed with the Childhood Autism Rating Scale Test-2, Strengths and Difficulties Questionnaire, and Pervasive Developmental Disorders Behavior Inventory Parent Ratings (PDDBI) and with the Battelle Developmental Inventory tests at the beginning of the study and after 24 months of follow-up. Fifty-two patients aged 2–6 years with ASD were included. Nineteen were classified with AMR, and 33 were classified with ANMR. Results: The AMR subgroup presented greater severity of autistic symptoms and higher autism scores. Additionally, they showed lower overall neurodevelopment. The AMR subgroup at 24 months had poorer scores on the Battelle Developmental Inventory test in the following areas: Total personal/social (p < 0.03), Total Motor (p < 0.04), Expressive (p < 0.01), and Battelle Total (p < 0.04). On the PDDBI test, the AMR subgroup had scores indicating significantly more severe ASD symptoms in the variables: ritual score (p < 0.038), social approach behaviors (p < 0.048), expressive language (p < 0.002), and autism score (p < 0.003). Conclusions: ASD patients exhibited a set of different neurological phenotypes. The AMR and ANMR subgroups presented different clinical manifestations and prognoses in terms of the severity of autistic symptoms and neurodevelopment.

ACS Style

Pilar Martin-Borreguero; Antonio Rafael Gómez-Fernández; Maria Jose De La Torre-Aguilar; Mercedes Gil-Campos; Katherine Flores-Rojas; Juan Luis Perez-Navero. Children With Autism Spectrum Disorder and Neurodevelopmental Regression Present a Severe Pattern After a Follow-Up at 24 Months. Frontiers in Psychiatry 2021, 12, 1 .

AMA Style

Pilar Martin-Borreguero, Antonio Rafael Gómez-Fernández, Maria Jose De La Torre-Aguilar, Mercedes Gil-Campos, Katherine Flores-Rojas, Juan Luis Perez-Navero. Children With Autism Spectrum Disorder and Neurodevelopmental Regression Present a Severe Pattern After a Follow-Up at 24 Months. Frontiers in Psychiatry. 2021; 12 ():1.

Chicago/Turabian Style

Pilar Martin-Borreguero; Antonio Rafael Gómez-Fernández; Maria Jose De La Torre-Aguilar; Mercedes Gil-Campos; Katherine Flores-Rojas; Juan Luis Perez-Navero. 2021. "Children With Autism Spectrum Disorder and Neurodevelopmental Regression Present a Severe Pattern After a Follow-Up at 24 Months." Frontiers in Psychiatry 12, no. : 1.

Journal article
Published: 20 February 2021 in Antioxidants
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The World Health Organization has recommended performing at least 60 min a day of moderate-to-vigorous physical activity (MVPA) and reducing sedentarism in children and adolescents to offer significant health benefits and mitigate health risks. Physical fitness and sports practice seem to improve oxidative stress (OS) status during childhood. However, to our knowledge, there are no data regarding the influence of objectively-measured physical activity (PA) and sedentarism on OS status in children and adolescents. The present study aimed to evaluate the influence of moderate and vigorous PA and sedentarism on OS and plasma total antioxidant capacity (TAC) in a selected Spanish population of 216 children and adolescents from the GENOBOX study. PA (light, moderate, and vigorous) and sedentarism (i.e., sedentary time (ST)) were measured by accelerometry. A Physical Activity-Sedentarism Score (PASS) was developed integrating moderate and vigorous PA and ST levels. Urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG) and isoprostane F2α (F2-IsoPs), as markers of OS, were determined by ELISA; and TAC was estimated by colorimetry using an antioxidant kit. A higher PASS was associated with lower plasma TAC and urinary 8-OHdG and F2-IsoPs, showing a better redox profile. Reduced OS markers (8-OHdG and F2-IsoPs) in children with higher PASS may diminish the need of maintaining high concentrations of antioxidants in plasma during rest to achieve redox homeostasis.

ACS Style

Francisco Llorente-Cantarero; Francisco Aguilar-Gómez; Rosaura Leis; Gloria Bueno; Azahara Rupérez; Augusto Anguita-Ruiz; Rocío Vázquez-Cobela; María Mesa; Luis Moreno; Ángel Gil; Concepción Aguilera; Mercedes Gil-Campos. Relationship between Physical Activity, Oxidative Stress, and Total Plasma Antioxidant Capacity in Spanish Children from the GENOBOX Study. Antioxidants 2021, 10, 320 .

AMA Style

Francisco Llorente-Cantarero, Francisco Aguilar-Gómez, Rosaura Leis, Gloria Bueno, Azahara Rupérez, Augusto Anguita-Ruiz, Rocío Vázquez-Cobela, María Mesa, Luis Moreno, Ángel Gil, Concepción Aguilera, Mercedes Gil-Campos. Relationship between Physical Activity, Oxidative Stress, and Total Plasma Antioxidant Capacity in Spanish Children from the GENOBOX Study. Antioxidants. 2021; 10 (2):320.

Chicago/Turabian Style

Francisco Llorente-Cantarero; Francisco Aguilar-Gómez; Rosaura Leis; Gloria Bueno; Azahara Rupérez; Augusto Anguita-Ruiz; Rocío Vázquez-Cobela; María Mesa; Luis Moreno; Ángel Gil; Concepción Aguilera; Mercedes Gil-Campos. 2021. "Relationship between Physical Activity, Oxidative Stress, and Total Plasma Antioxidant Capacity in Spanish Children from the GENOBOX Study." Antioxidants 10, no. 2: 320.

Journal article
Published: 30 December 2020 in ACTUALIDAD MEDICA
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Aim: In recent years, there has been a remarkable increase in eating disorders among pediatric patients. The identification of certain clinical profiles allows us to better understand predisposing or triggering factors, as well as disorder prognosis in this age range. Therefore, the main objective of this study is to describe the patterns of pediatric patients with eating disorders to improve the approach of Pediatricians for these early-onset disorders and promote protocolized interventions as an essential tool to improve the health of these children. Methods: A retrospective study of pediatric patients diagnosed with eating disorders from 2009 to 2019 in a third-level pediatric hospital evaluated the demographic, biographical, anthropometric, psychiatric, and clinical characteristics, as well as others related to diagnosis and treatment. Results: Symptoms among children are similar to those experienced by adults and adolescents; however, incomplete forms of the disease are more frequent in children. The main differences between the age groups include a more equitable sex ratio, a shorter time evolution of the disease before diagnosis, less deterioration of overall health state in the first evaluation and a shorter duration of the disorder. Conclusions: The best prognosis in children could be explained by the closer medical follow-up of these patients and their better adherence to treatment, the early intervention of parents and higher dependence on their caregivers in food choices and intake. In addition, greater plasticity for psychological treatment and coordination of the multidisciplinary team in the care process also contributed the observed trend.

ACS Style

F. Ramírez-Sánchez; S. Jaimez-Pérez; M. Gil-Campos; K. Flores-Rojas. The experience in pediatric patients with eating disorder for 10 years. ACTUALIDAD MEDICA 2020, 105, 182 -189.

AMA Style

F. Ramírez-Sánchez, S. Jaimez-Pérez, M. Gil-Campos, K. Flores-Rojas. The experience in pediatric patients with eating disorder for 10 years. ACTUALIDAD MEDICA. 2020; 105 (105(811)):182-189.

Chicago/Turabian Style

F. Ramírez-Sánchez; S. Jaimez-Pérez; M. Gil-Campos; K. Flores-Rojas. 2020. "The experience in pediatric patients with eating disorder for 10 years." ACTUALIDAD MEDICA 105, no. 105(811): 182-189.

Journal article
Published: 08 November 2020 in Nutrients
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Diet is a key factor for obesity development; however, limited data are available on dietary cluster analysis in children with obesity. We aimed to assess the associations between dietary patterns and obesity and several cardiometabolic markers. Anthropometry, bioelectrical impedance, blood pressure and plasma biomarkers of oxidative stress, inflammation and endothelial damage were determined in 674 Caucasian children, aged 5–16, with normal or excess weight. Using a food frequency questionnaire and cluster analysis, two consistent dietary patterns were shown, labeled as health conscious (HC) and sweet and processed (SP). The HC pattern included a greater proportion of participants with overweight/obesity than the SP cluster (80.1% vs. 63.8%). However, children with obesity within the HC cluster, showed less abdominal fat, through waist to hip (0.93 vs. 0.94) and waist to height (0.61 vs. 0.63) indexes (p < 0.01). Univariate general models showed several additional differences in cardiometabolic risk biomarkers in the global and stratified analyses, with a healthier profile being observed mainly in the HC cluster. However, multivariate models questioned these findings and pointed out the need for further studies in this field. Anyhow, our findings support the benefits of a healthy diet and highlight the importance of dietary patterns in the cardiometabolic risk assessment of children with overweight/obesity, beyond weight control.

ACS Style

Miriam Latorre-Millán; Azahara Rupérez; Esther González-Gil; Alba Santaliestra-Pasías; Rocío Vázquez-Cobela; Mercedes Gil-Campos; Concepción Aguilera; Ángel Gil; Luis Moreno; Rosaura Leis; Gloria Bueno. Dietary Patterns and Their Association with Body Composition and Cardiometabolic Markers in Children and Adolescents: Genobox Cohort. Nutrients 2020, 12, 3424 .

AMA Style

Miriam Latorre-Millán, Azahara Rupérez, Esther González-Gil, Alba Santaliestra-Pasías, Rocío Vázquez-Cobela, Mercedes Gil-Campos, Concepción Aguilera, Ángel Gil, Luis Moreno, Rosaura Leis, Gloria Bueno. Dietary Patterns and Their Association with Body Composition and Cardiometabolic Markers in Children and Adolescents: Genobox Cohort. Nutrients. 2020; 12 (11):3424.

Chicago/Turabian Style

Miriam Latorre-Millán; Azahara Rupérez; Esther González-Gil; Alba Santaliestra-Pasías; Rocío Vázquez-Cobela; Mercedes Gil-Campos; Concepción Aguilera; Ángel Gil; Luis Moreno; Rosaura Leis; Gloria Bueno. 2020. "Dietary Patterns and Their Association with Body Composition and Cardiometabolic Markers in Children and Adolescents: Genobox Cohort." Nutrients 12, no. 11: 3424.

Journal article
Published: 02 October 2020 in International Journal of Environmental Research and Public Health
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Longitudinal changes of physical activity (PA) from childhood into adolescence have not been accurately described yet for the Spanish population. The aim of this study is to evaluate the changes of PA, assessed by accelerometry and anthropometric measures in a cohort of 213 children from the prepubertal to pubertal period, focusing on those with valid data from both time points (n = 75). Sedentary time (ST) increased about 50%, while all PA intensities declined from the pre-pubertal to pubertal period. Light PA (LPA) was the major contributor, decreasing by about 30%. Boys were more active than girls in both periods, but they showed a higher decline in PA, especially moderate-to-vigorous PA (MVPA). The proportion who reached the recommendation of 60 min of MVPA decreased by 33.3% in boys and 4.6% in girls. Children with obesity or overweight had lower MVPA than those with normal-weight in the pre-pubertal period, but no differences were found in the pubertal period. This study shows a decrease of PA and an increase of sedentarism in the transition from childhood to adolescence, particularly in boys. Regardless of body weight, adolescents tend to be less active. Therefore, prevention programs should be implemented to achieve optimal PA and reduce sedentarism during infancy considering the differences found by sex.

ACS Style

Francisco Jesús Llorente-Cantarero; Francisco Javier Aguilar-Gómez; Augusto Anguita-Ruiz; Azahara Iris Rupérez; Rocío Vázquez-Cobela; Katherine Flores-Rojas; Concepción M. Aguilera; Esther M. Gonzalez-Gil; Mercedes Gil-Campos; Gloria Bueno-Lozano; Rosaura Leis. Changes in Physical Activity Patterns from Childhood to Adolescence: Genobox Longitudinal Study. International Journal of Environmental Research and Public Health 2020, 17, 7227 .

AMA Style

Francisco Jesús Llorente-Cantarero, Francisco Javier Aguilar-Gómez, Augusto Anguita-Ruiz, Azahara Iris Rupérez, Rocío Vázquez-Cobela, Katherine Flores-Rojas, Concepción M. Aguilera, Esther M. Gonzalez-Gil, Mercedes Gil-Campos, Gloria Bueno-Lozano, Rosaura Leis. Changes in Physical Activity Patterns from Childhood to Adolescence: Genobox Longitudinal Study. International Journal of Environmental Research and Public Health. 2020; 17 (19):7227.

Chicago/Turabian Style

Francisco Jesús Llorente-Cantarero; Francisco Javier Aguilar-Gómez; Augusto Anguita-Ruiz; Azahara Iris Rupérez; Rocío Vázquez-Cobela; Katherine Flores-Rojas; Concepción M. Aguilera; Esther M. Gonzalez-Gil; Mercedes Gil-Campos; Gloria Bueno-Lozano; Rosaura Leis. 2020. "Changes in Physical Activity Patterns from Childhood to Adolescence: Genobox Longitudinal Study." International Journal of Environmental Research and Public Health 17, no. 19: 7227.

Journal article
Published: 18 September 2020 in Biomedicines
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Background: Asthma is a multifactorial condition where patients with identical clinical diagnoses do not have the same clinical history or respond to treatment. This clinical heterogeneity is reflected in the definition of two main endotypes. We aimed to explore the metabolic and microbiota signatures that characterize the clinical allergic asthma phenotype in obese children. Methods: We used a multi-omics approach combining clinical data, plasma and fecal inflammatory biomarkers, metagenomics, and metabolomics data in a cohort of allergic asthmatic children. Results: We observed that the obese allergic asthmatic phenotype was markedly associated with higher levels of leptin and lower relative proportions of plasma acetate and a member from the Clostridiales order. Moreover, allergic children with a worse asthma outcome showed higher levels of large unstained cells, fecal D lactate and D/L lactate ratio, and with a higher relative proportion of plasma creatinine and an unclassified family member from the RF39 order belonging to the Mollicutes class. Otherwise, children with persistent asthma presented lower levels of plasma citrate and dimethylsulfone. Conclusion: Our integrative approach shows the molecular heterogeneity of the allergic asthma phenotype while highlighting the use of omics technologies to examine the clinical phenotype at a more holistic level.

ACS Style

Mª Amelia Gomez-Llorente; Ana Martínez-Cañavate; Natalia Chueca; Mª De La Cruz Rico; Raquel Romero; Augusto Anguita-Ruiz; Concepción Mª Aguilera; Mercedes Gil-Campos; Maria D Mesa; Bekzod Khakimov; Jose Antonio Morillo; Ángel Gil; José Camacho; Carolina Gomez-Llorente. A Multi-Omics Approach Reveals New Signatures in Obese Allergic Asthmatic Children. Biomedicines 2020, 8, 359 .

AMA Style

Mª Amelia Gomez-Llorente, Ana Martínez-Cañavate, Natalia Chueca, Mª De La Cruz Rico, Raquel Romero, Augusto Anguita-Ruiz, Concepción Mª Aguilera, Mercedes Gil-Campos, Maria D Mesa, Bekzod Khakimov, Jose Antonio Morillo, Ángel Gil, José Camacho, Carolina Gomez-Llorente. A Multi-Omics Approach Reveals New Signatures in Obese Allergic Asthmatic Children. Biomedicines. 2020; 8 (9):359.

Chicago/Turabian Style

Mª Amelia Gomez-Llorente; Ana Martínez-Cañavate; Natalia Chueca; Mª De La Cruz Rico; Raquel Romero; Augusto Anguita-Ruiz; Concepción Mª Aguilera; Mercedes Gil-Campos; Maria D Mesa; Bekzod Khakimov; Jose Antonio Morillo; Ángel Gil; José Camacho; Carolina Gomez-Llorente. 2020. "A Multi-Omics Approach Reveals New Signatures in Obese Allergic Asthmatic Children." Biomedicines 8, no. 9: 359.

Review
Published: 19 August 2020 in International Journal of Environmental Research and Public Health
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Despite the existence of global recommendations for physical activity and lifestyle to avoid childhood obesity, there are no specific recommendations for school-age children. The aim of this meta-analysis was to measure the effects of current interventions with a physical activity component on body mass index (BMI) Z-score and on the moderate and vigorous physical activity (MVPA) time, measured by accelerometry, and focused on children with obesity. Randomized controlled trial studies (RCTs) based on physical activity interventions focused on children with obesity (6 to 12 years old) from January 1991 to August 2018 were included. The post-intervention mean and standard deviation of the BMI Z-score and MVPA engaged time were extracted to calculate the results using random effects models. Of a total of 229 studies considered potentially eligible, only 10 RCTs met the inclusion criteria. There were improvements in the BMI Z-score for physical activity intervention groups, compared with non-intervention children in addition to a significant increase in time engaged in MVPA. In conclusion, interventions with a physical activity component in school-children with obesity seem to be effective at reducing BMI and producing an increase in time spent engaged in physical activity. Therefore, interventions based on physical activity should be considered one of the main strategies in treating childhood obesity.

ACS Style

Jose Manuel Jurado-Castro; Mercedes Gil-Campos; Hugo Gonzalez-Gonzalez; Francisco Jesus Llorente-Cantarero. Evaluation of Physical Activity and Lifestyle Interventions Focused on School Children with Obesity Using Accelerometry: A Systematic Review and Meta-Analysis. International Journal of Environmental Research and Public Health 2020, 17, 6031 .

AMA Style

Jose Manuel Jurado-Castro, Mercedes Gil-Campos, Hugo Gonzalez-Gonzalez, Francisco Jesus Llorente-Cantarero. Evaluation of Physical Activity and Lifestyle Interventions Focused on School Children with Obesity Using Accelerometry: A Systematic Review and Meta-Analysis. International Journal of Environmental Research and Public Health. 2020; 17 (17):6031.

Chicago/Turabian Style

Jose Manuel Jurado-Castro; Mercedes Gil-Campos; Hugo Gonzalez-Gonzalez; Francisco Jesus Llorente-Cantarero. 2020. "Evaluation of Physical Activity and Lifestyle Interventions Focused on School Children with Obesity Using Accelerometry: A Systematic Review and Meta-Analysis." International Journal of Environmental Research and Public Health 17, no. 17: 6031.

Journal article
Published: 15 July 2020 in Antioxidants
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Oxidative stress could help explain the relationship between childhood obesity and a metabolically unhealthy (MU) status. Moreover, puberty could also influence this relationship, since it entails physiological cardiometabolic changes. We aimed to evaluate plasma antioxidants and oxidative stress biomarkers in MU and metabolically healthy (MH) prepubertal and pubertal children and their associations with pro-inflammatory and endothelial damage biomarkers, taking puberty into account. A total of 1444 Spanish children aged 3–17 years (48.9% males, 66% prepubertal, 47.1% with obesity) were recruited. Blood pressure, anthropometric and biochemical parameters were measured, and children were categorized as having a MU or MH status according to risk factors. Retinol, carotenes, tocopherols, total antioxidant capacity (TAC), oxidized low-density lipoprotein and selected pro-inflammatory and endothelial damage biomarkers were analyzed. General linear models adjusted for age, sex, recruitment center and body mass index, partial correlations and stepwise linear regressions were performed. Lower carotenes and tocopherols levels were found in MU than in MH children. Plasma TAC was lower in prepubertal and higher in pubertal children with obesity compared to normal-weight children. Antioxidants and oxidative stress biomarkers showed novel associations with several pro-inflammatory and endothelial damage biomarkers, with pubertal differences, supporting the importance of considering both the antioxidant and oxidative stress status and puberty in the prevention of metabolic diseases in childhood.

ACS Style

Azahara I. Rupérez; María D. Mesa; Augusto Anguita-Ruiz; Esther M. González-Gil; Rocío Vázquez-Cobela; Luis A. Moreno; Ángel Gil; Mercedes Gil-Campos; Rosaura Leis; Gloria Bueno; Concepción M. Aguilera. Antioxidants and Oxidative Stress in Children: Influence of Puberty and Metabolically Unhealthy Status. Antioxidants 2020, 9, 618 .

AMA Style

Azahara I. Rupérez, María D. Mesa, Augusto Anguita-Ruiz, Esther M. González-Gil, Rocío Vázquez-Cobela, Luis A. Moreno, Ángel Gil, Mercedes Gil-Campos, Rosaura Leis, Gloria Bueno, Concepción M. Aguilera. Antioxidants and Oxidative Stress in Children: Influence of Puberty and Metabolically Unhealthy Status. Antioxidants. 2020; 9 (7):618.

Chicago/Turabian Style

Azahara I. Rupérez; María D. Mesa; Augusto Anguita-Ruiz; Esther M. González-Gil; Rocío Vázquez-Cobela; Luis A. Moreno; Ángel Gil; Mercedes Gil-Campos; Rosaura Leis; Gloria Bueno; Concepción M. Aguilera. 2020. "Antioxidants and Oxidative Stress in Children: Influence of Puberty and Metabolically Unhealthy Status." Antioxidants 9, no. 7: 618.

Review article
Published: 02 July 2020 in Current Opinion in Endocrine and Metabolic Research
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Metabolic syndrome (MetS) is defined as a cluster of alterations related with insulin resistance (obesity, dyslipidemia, hypertension, and impaired glucose metabolism), which are associated with a higher risk of cardiovascular disease in adults. Several definitions have been proposed for older children and adolescents. However, no definitions have been made in accordance with pubertal status, and those in prepubertal state have not received attention enough, despite there are data suggesting the early presence of risk factors. The new insights concerning healthy and unhealthy metabolic status or the addition of novel metabolic risk biomarkers, may contribute to the knowledge about the development of MetS in children. This manuscript reviews the available evidence on MetS during childhood, focusing on the prepubertal period.

ACS Style

Francisco Javier Aguilar-Gomez; Gloria Bueno-Lozano; Rosaura Leis; Concepción María Aguilera; Mercedes Gil-Campos. Metabolic syndrome before puberty: Myth or reality? Current Opinion in Endocrine and Metabolic Research 2020, 14, 97 -103.

AMA Style

Francisco Javier Aguilar-Gomez, Gloria Bueno-Lozano, Rosaura Leis, Concepción María Aguilera, Mercedes Gil-Campos. Metabolic syndrome before puberty: Myth or reality? Current Opinion in Endocrine and Metabolic Research. 2020; 14 ():97-103.

Chicago/Turabian Style

Francisco Javier Aguilar-Gomez; Gloria Bueno-Lozano; Rosaura Leis; Concepción María Aguilera; Mercedes Gil-Campos. 2020. "Metabolic syndrome before puberty: Myth or reality?" Current Opinion in Endocrine and Metabolic Research 14, no. : 97-103.

Journal article
Published: 02 June 2020 in Journal of Clinical Medicine
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Polygenetic risk scores (pGRSs) consisting of adult body mass index (BMI) genetic variants have been widely associated with obesity in children populations. The implication of such obesity pGRSs in the development of cardio-metabolic alterations during childhood as well as their utility for the clinical prediction of pubertal obesity outcomes has been barely investigated otherwise. In the present study, we evaluated the utility of an adult BMI predisposing pGRS for the prediction and pharmacological management of obesity in Spanish children, further investigating its implication in the appearance of cardio-metabolic alterations. For that purpose, we counted on genetics data from three well-characterized children populations (composed of 574, 96 and 124 individuals), following both cross-sectional and longitudinal designs, expanding childhood and puberty. As a result, we demonstrated that the pGRS is strongly associated with childhood BMI Z-Score (B = 1.56, SE = 0.27 and p-value = 1.90 × 10−8), and that could be used as a good predictor of obesity longitudinal trajectories during puberty. On the other hand, we showed that the pGRS is not associated with cardio-metabolic comorbidities in children and that certain environmental factors interact with the genetic predisposition to the disease. Finally, according to the results derived from a weight-reduction metformin intervention in children with obesity, we discarded the utility of the pGRS as a pharmacogenetics marker of metformin response.

ACS Style

Augusto Anguita-Ruiz; Esther María González Gil; Azahara I. Rupérez; Francisco Jesús Llorente-Cantarero; Belén Pastor-Villaescusa; Jesús Alcalá-Fdez; Luis A. Moreno; Ángel Gil; Mercedes Gil-Campos; Gloria Bueno; Rosaura Leis; Concepción M. Aguilera. Evaluation of the Predictive Ability, Environmental Regulation and Pharmacogenetics Utility of a BMI-Predisposing Genetic Risk Score during Childhood and Puberty. Journal of Clinical Medicine 2020, 9, 1 .

AMA Style

Augusto Anguita-Ruiz, Esther María González Gil, Azahara I. Rupérez, Francisco Jesús Llorente-Cantarero, Belén Pastor-Villaescusa, Jesús Alcalá-Fdez, Luis A. Moreno, Ángel Gil, Mercedes Gil-Campos, Gloria Bueno, Rosaura Leis, Concepción M. Aguilera. Evaluation of the Predictive Ability, Environmental Regulation and Pharmacogenetics Utility of a BMI-Predisposing Genetic Risk Score during Childhood and Puberty. Journal of Clinical Medicine. 2020; 9 (6):1.

Chicago/Turabian Style

Augusto Anguita-Ruiz; Esther María González Gil; Azahara I. Rupérez; Francisco Jesús Llorente-Cantarero; Belén Pastor-Villaescusa; Jesús Alcalá-Fdez; Luis A. Moreno; Ángel Gil; Mercedes Gil-Campos; Gloria Bueno; Rosaura Leis; Concepción M. Aguilera. 2020. "Evaluation of the Predictive Ability, Environmental Regulation and Pharmacogenetics Utility of a BMI-Predisposing Genetic Risk Score during Childhood and Puberty." Journal of Clinical Medicine 9, no. 6: 1.

Journal article
Published: 01 May 2020 in Nutrients
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Sedentary habits during childhood are associated with adverse health outcomes. The aim of this work was to cluster lifestyle behaviors and metabolic biomarkers to establish different patterns in children. Their physical and sedentary activities were evaluated by accelerometry, and questionnaires that included lifestyle behaviors, such as adherence to a Mediterranean diet, anthropometry and blood biochemical markers. Cluster analysis was performed to establish different groups based on physical activity levels. A total of 489 children were finally selected. Cluster 1 included children with a mostly sedentary state, whereas Cluster 3 included the most active children and Cluster 2 included children that did not fit into either the sedentary or the highly active groups. In Cluster 3, 56% of children were in a sports club, and a lower percentage used electronic devices in their rooms compared to the other groups. Cluster 1 children exhibited higher insulin, HOMA-IR and triacylglycerides with respect to the other groups. No differences were found regarding adherence to a Mediterranean diet. The choice to practice an extracurricular sport could be an influencing factor to increase exercise and ensure an active lifestyle in children. Reducing or limiting screen time mainly in children’s rooms could contribute to an active lifestyle.

ACS Style

Rosaura Leis; Jose Manuel Jurado-Castro; Francisco Jesus Llorente-Cantarero; Augusto Anguita-Ruiz; Azahara Iris Rupérez; Juan Jose Bedoya-Carpente; Rocío Vázquez-Cobela; Concepción María Aguilera; Gloria Bueno; Mercedes Gil-Campos. Cluster Analysis of Physical Activity Patterns, and Relationship with Sedentary Behavior and Healthy Lifestyles in Prepubertal Children: Genobox Cohort. Nutrients 2020, 12, 1288 .

AMA Style

Rosaura Leis, Jose Manuel Jurado-Castro, Francisco Jesus Llorente-Cantarero, Augusto Anguita-Ruiz, Azahara Iris Rupérez, Juan Jose Bedoya-Carpente, Rocío Vázquez-Cobela, Concepción María Aguilera, Gloria Bueno, Mercedes Gil-Campos. Cluster Analysis of Physical Activity Patterns, and Relationship with Sedentary Behavior and Healthy Lifestyles in Prepubertal Children: Genobox Cohort. Nutrients. 2020; 12 (5):1288.

Chicago/Turabian Style

Rosaura Leis; Jose Manuel Jurado-Castro; Francisco Jesus Llorente-Cantarero; Augusto Anguita-Ruiz; Azahara Iris Rupérez; Juan Jose Bedoya-Carpente; Rocío Vázquez-Cobela; Concepción María Aguilera; Gloria Bueno; Mercedes Gil-Campos. 2020. "Cluster Analysis of Physical Activity Patterns, and Relationship with Sedentary Behavior and Healthy Lifestyles in Prepubertal Children: Genobox Cohort." Nutrients 12, no. 5: 1288.

Journal article
Published: 24 April 2020 in Nutrients
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Adipose tissue programming could be developed in very preterm infants with extrauterine growth restriction (EUGR), with an adverse impact on long-term metabolic status, as was studied in intrauterine growth restriction patterns. The aim of this cohort study was to evaluate the difference in levels of plasma adipokines in children with a history of EUGR. A total of 211 school age prepubertal children were examined: 38 with a history of prematurity and EUGR (EUGR), 50 with a history of prematurity with adequate growth (PREM), and 123 healthy children born at term. Anthropometric parameters, blood pressure, metabolic markers and adipokines (adiponectin, resistin, leptin) were measured. Children with a history of EUGR showed lower values of adiponectin (μg/mL) compared with the other two groups: (EUGR: 10.6 vs. PREM: 17.7, p < 0.001; vs. CONTROL: 25.7, p = 0.004) and higher levels of resistin (ng/mL) (EUGR: 19.2 vs. PREM: 16.3, p =0.007; vs. CONTROL: 7.1, p < 0.001. The PREM group showed the highest values of leptin (ng/mL), compared with the others: PREM: 4.9 vs. EUGR: 2.1, p = 0.048; vs. CONTROL: 3.2, p = 0.029). In conclusion, EUGR in premature children could lead to a distinctive adipokines profile, likely associated with an early programming of the adipose tissue, and likely to increase the risk of adverse health outcomes later in life.

ACS Style

María Dolores Ordóñez-Díaz; Mercedes Gil-Campos; Katherine Flores-Rojas; María Carmen Muñoz-Villanueva; Concepción María Aguilera-García; María Jose De La Torre-Aguilar; Juan Luis Pérez-Navero. Plasma Adipokines Profile in Prepubertal Children with a History of Prematurity or Extrauterine Growth Restriction. Nutrients 2020, 12, 1201 .

AMA Style

María Dolores Ordóñez-Díaz, Mercedes Gil-Campos, Katherine Flores-Rojas, María Carmen Muñoz-Villanueva, Concepción María Aguilera-García, María Jose De La Torre-Aguilar, Juan Luis Pérez-Navero. Plasma Adipokines Profile in Prepubertal Children with a History of Prematurity or Extrauterine Growth Restriction. Nutrients. 2020; 12 (4):1201.

Chicago/Turabian Style

María Dolores Ordóñez-Díaz; Mercedes Gil-Campos; Katherine Flores-Rojas; María Carmen Muñoz-Villanueva; Concepción María Aguilera-García; María Jose De La Torre-Aguilar; Juan Luis Pérez-Navero. 2020. "Plasma Adipokines Profile in Prepubertal Children with a History of Prematurity or Extrauterine Growth Restriction." Nutrients 12, no. 4: 1201.

Journal article
Published: 09 April 2020 in Nutrients
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High blood pressure (BP) is a risk factor for cardiovascular disease and sodium consumption is related to high BP. Moreover, sugar-sweetened beverages (SSB) and the Dietary Approach to Stop Hypertension (DASH) influence BP. For this reason, we investigated whether: 1) children with risk of elevated BP had a higher consumption frequency (CF) of energy-dense salty foods (EDSF), high-sugary foods (HSF) and SSB or a low DASH score; and 2) children with a higher CF of EDSF showed a worse anthropometric and metabolic profile. Anthropometry, BP and general biochemical parameters were measured in 687 Spanish children (5–16 years) with normal or excess weight. A food frequency questionnaire was used to calculate EDSF, HSF and SSB consumption, and modified DASH score. Results showed that sex and pubertal stage influenced modified DASH score. Diastolic hypertension was associated to higher CF of EDSF in the whole sample and to higher CF of SSB in pubertal children, both independently of nutritional status. In addition, CF of EDSF was positively associated with CF of HSF and SSB and inversely associated with modified DASH score. Targeted policies and intervention programs, specific for different age ranges, should be established that aim to reduce salt consumption from snacks and processed foods, which could reduce HSF and SSB consumption as well.

ACS Style

Gloria Pérez-Gimeno; Azahara I. Rupérez; Rocío Vázquez-Cobela; Gonzalo Herráiz-Gastesi; Mercedes Gil-Campos; Concepción M. Aguilera; Luis A. Moreno; María Rosaura Leis Trabazo; Gloria Bueno-Lozano. Energy Dense Salty Food Consumption Frequency Is Associated with Diastolic Hypertension in Spanish Children. Nutrients 2020, 12, 1027 .

AMA Style

Gloria Pérez-Gimeno, Azahara I. Rupérez, Rocío Vázquez-Cobela, Gonzalo Herráiz-Gastesi, Mercedes Gil-Campos, Concepción M. Aguilera, Luis A. Moreno, María Rosaura Leis Trabazo, Gloria Bueno-Lozano. Energy Dense Salty Food Consumption Frequency Is Associated with Diastolic Hypertension in Spanish Children. Nutrients. 2020; 12 (4):1027.

Chicago/Turabian Style

Gloria Pérez-Gimeno; Azahara I. Rupérez; Rocío Vázquez-Cobela; Gonzalo Herráiz-Gastesi; Mercedes Gil-Campos; Concepción M. Aguilera; Luis A. Moreno; María Rosaura Leis Trabazo; Gloria Bueno-Lozano. 2020. "Energy Dense Salty Food Consumption Frequency Is Associated with Diastolic Hypertension in Spanish Children." Nutrients 12, no. 4: 1027.

Original article
Published: 24 February 2020 in European Journal of Pediatrics
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Extrauterine growth restriction (EUGR) is a frequent morbidity of preterm infants that can affect short- and long-term prognosis as it involves different EUGR-related alterations in growth and neurological development, as well as cardiometabolic risk. However, knowledge about the prognosis of EUGR is scarce. Thus, the objective of this study is to review the evidence regarding EUGR-related comorbidities in childhood by a systematic approach. This review was carried out using the Joanna Briggs Institute Reviewers’ Manual Methodology and the PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analyses)-Search Extension for scoping review. The MEDLINE and EMBASE databases were used to identify papers published until September 2017. Twenty-four publications were included and 19 examined cohort studies. EUGR is mainly associated with (1) lower weight, length, and head circumference measures in childhood; (2) poor neurodevelopment; and (3) alterations in cardiometabolic risk markers. The definition for EUGR and the populations studied differ among authors. Conclusion: EUGR is mainly associated with poor growth and neurodevelopment, as well as with cardiometabolic alterations in childhood. Evidence is based on observational studies with variability in the included populations due to the lack of consensus regarding the definition for EUGR. Finding a gold standard definition becomes paramount in order to select phenotypes at risk later in life.

ACS Style

M D Martínez-Jiménez; F J Gómez-García; M Gil-Campos; J L Pérez-Navero. Comorbidities in childhood associated with extrauterine growth restriction in preterm infants: a scoping review. European Journal of Pediatrics 2020, 179, 1255 -1265.

AMA Style

M D Martínez-Jiménez, F J Gómez-García, M Gil-Campos, J L Pérez-Navero. Comorbidities in childhood associated with extrauterine growth restriction in preterm infants: a scoping review. European Journal of Pediatrics. 2020; 179 (8):1255-1265.

Chicago/Turabian Style

M D Martínez-Jiménez; F J Gómez-García; M Gil-Campos; J L Pérez-Navero. 2020. "Comorbidities in childhood associated with extrauterine growth restriction in preterm infants: a scoping review." European Journal of Pediatrics 179, no. 8: 1255-1265.

Review
Published: 21 December 2019 in Nutrients
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Childhood obesity is a global public health issue and is linked to metabolic syndrome, which increases the risk of comorbidities such as type 2 diabetes, cardiovascular diseases and cancer. Social, economic and cultural factors influence changes in nutrition and lifestyle characterized by poorer diets and reduced physical activity. This systematic review summarizes the evidence for nutritional education interventions to improve metabolic risks in children and adolescents. Systematic searches of the databases Medline (via PubMed) and Scopus were conducted following PRISMA guidelines. The risk of bias for each study was assessed following the methodology of the Cochrane Collaboration. Ten case-controlled and randomized controlled studies testing nutritional educational interventions targeting children and adolescents from the general population were eligible for inclusion. The sample size was 3915 and the age range was 7–20 years. The duration of intervention ranged from 12 weeks to 20 years. All the studies that provided data on abdominal obesity reported differences in favour of the intervention. However, data on the effects on the remaining components of metabolic syndrome remain inconclusive. These results support the role of nutritional education interventions as a strategy to reduce central adiposity and its possible unhealthy consequences in children and adolescents.

ACS Style

Rosaura Leis; Carmela De Lamas; María-José De Castro; Rosaura Picáns; Mercedes Gil-Campos; María L. Couce. Effects of Nutritional Education Interventions on Metabolic Risk in Children and Adolescents: A Systematic Review of Controlled Trials. Nutrients 2019, 12, 31 .

AMA Style

Rosaura Leis, Carmela De Lamas, María-José De Castro, Rosaura Picáns, Mercedes Gil-Campos, María L. Couce. Effects of Nutritional Education Interventions on Metabolic Risk in Children and Adolescents: A Systematic Review of Controlled Trials. Nutrients. 2019; 12 (1):31.

Chicago/Turabian Style

Rosaura Leis; Carmela De Lamas; María-José De Castro; Rosaura Picáns; Mercedes Gil-Campos; María L. Couce. 2019. "Effects of Nutritional Education Interventions on Metabolic Risk in Children and Adolescents: A Systematic Review of Controlled Trials." Nutrients 12, no. 1: 31.

Journal article
Published: 21 October 2019 in BMC Pediatrics
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Background The microorganism present in breast milk, added to other factors, determine the colonization of infants. The objective of the present study is to evaluate the safety, tolerance and effects of the consumption of a milk formula during the first year of life that is supplemented with L. fermentum CECT5716 or Bifidobacterium breve CECT7263, two strains originally isolated from breast milk. Methods A randomized, double blind, controlled, parallel group study including healthy, formula-fed infants was conducted. Two hundred and thirty-six 1-month-old infants were selected and randomly divided into three study groups according to a randomization list. Infants in the control group received a standard powdered infant formula until 12 months of age. Infants in the probiotic groups received the same infant formula but supplemented with L. fermentum CECT5716 Lc40 or B. breve CECT7263. Main outcome was weigh-gain of infants as safety marker. Results One hundred and eighty-nine infants completed the eleven months of intervention (61 in control group, 65 in Lf group and 63 in Bb group). The growth of infants in the three groups was consistent with standards. No significant differences were observed in the main outcome, weight-gain (Control group: 5.77 Kg ± 0.95, Lf group: 5.77 Kg ± 1.31, Bb group: 5.58 Kg ± 1.10; p = 0.527). The three milk formulae were well tolerated, and no adverse effects were related to the consumption of any of the formula. Infants receiving B. breve CECT7263 had a 1.7 times lower risk of crying than the control group (OR = 0.569, CI 95% 0.568–0.571; p = 0.001). On the other hand, the incidence of diarrhoea in infants receiving the formula supplemented with L. fermentum CECT5716 was a 44% lower than in infants receiving the control formula (p = 0.014). The consumption of this Lactobacillus strain also reduced the duration of diarrhoea by 2.5 days versus control group (p = 0.044). Conclusions The addition of L. fermentum CECT5716 Lc40 or B. breve CECT7263, two probiotic strains naturally found in breast milk, to infant formulae is safe and induces beneficial effects on the health of infants. Trial registration The trial was retrospectively registered in the US Library of Medicine (www.clinicaltrial.gov) with the number NCT03204630. Registered 11 August 2016.

ACS Style

J. Maldonado; M. Gil-Campos; J. A. Maldonado-Lobón; M. R. Benavides; K. Flores-Rojas; R. Jaldo; I. Jiménez Del Barco; V. Bolívar; A. D. Valero; E. Prados; I. Peñalver; M. Olivares. Evaluation of the safety, tolerance and efficacy of 1-year consumption of infant formula supplemented with Lactobacillus fermentum CECT5716 Lc40 or Bifidobacterium breve CECT7263: a randomized controlled trial. BMC Pediatrics 2019, 19, 361 -15.

AMA Style

J. Maldonado, M. Gil-Campos, J. A. Maldonado-Lobón, M. R. Benavides, K. Flores-Rojas, R. Jaldo, I. Jiménez Del Barco, V. Bolívar, A. D. Valero, E. Prados, I. Peñalver, M. Olivares. Evaluation of the safety, tolerance and efficacy of 1-year consumption of infant formula supplemented with Lactobacillus fermentum CECT5716 Lc40 or Bifidobacterium breve CECT7263: a randomized controlled trial. BMC Pediatrics. 2019; 19 (1):361-15.

Chicago/Turabian Style

J. Maldonado; M. Gil-Campos; J. A. Maldonado-Lobón; M. R. Benavides; K. Flores-Rojas; R. Jaldo; I. Jiménez Del Barco; V. Bolívar; A. D. Valero; E. Prados; I. Peñalver; M. Olivares. 2019. "Evaluation of the safety, tolerance and efficacy of 1-year consumption of infant formula supplemented with Lactobacillus fermentum CECT5716 Lc40 or Bifidobacterium breve CECT7263: a randomized controlled trial." BMC Pediatrics 19, no. 1: 361-15.

Original article
Published: 27 June 2019 in Metabolomics
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It is challenging to establish the mechanisms involved in the variety of well-defined clinical phenotypes in autism spectrum disorder (ASD) and the pathways involved in their pathogeneses. The aim of the present study was to evaluate the metabolomic profiles of children with ASD subclassified by mental regression (AR) phenotype and with no regression (ANR). The present study was a cross-sectional case–control study. Thirty children aged 2–6 years with ASD were included: 15 with ANR and 15 with AR. In addition, a control group of 30 normally developing children was selected and matched to the ASD group by sex and age. Plasma samples were analyzed with a metabolomics single platform methodology based on liquid chromatography-mass spectrometry. Univariate and multivariate analysis, including orthogonal partial least squares-discriminant analysis modeling and Shared-and-Unique-Structures plots, were performed using MetaboAnalyst 4.0 and SIMCA-P 15. The primary endpoint was the metabolic signature profiling among healthy children and autistic children and their subgroups. Metabolomic profiles of 30 healthy children, 15 ANR and 15 AR were compared. Several differences between healthy children and children with ASD were detected, involving mainly amino acid, lipid and nicotinamide metabolism. Furthermore, we report subtle differences between the ANR and AR groups. In this study, we report, for the first time, the plasmatic metabolomic profiles of children with ASD, including two different phenotypes based on mental regression status. The use of a liquid chromatography-mass spectrometry platform approach for metabolomics in ASD children using plasma appears to be very efficient and adds further support to previous findings in urine. Furthermore, the present study documents several changes related to amino acid, NAD+ and lipid metabolism that, in some cases, such as arginine and glutamate pathway alterations, seem to be associated with the AR phenotype. Further targeted analyses are needed in a larger cohort to validate the results presented herein.

ACS Style

O. D. Rangel-Huerta; A. Gomez-Fernández; M. J. De La Torre-Aguilar; A. Gil; J. L. Perez-Navero; K. Flores-Rojas; P. Martín-Borreguero; M. Gil-Campos. Metabolic profiling in children with autism spectrum disorder with and without mental regression: preliminary results from a cross-sectional case–control study. Metabolomics 2019, 15, 99 .

AMA Style

O. D. Rangel-Huerta, A. Gomez-Fernández, M. J. De La Torre-Aguilar, A. Gil, J. L. Perez-Navero, K. Flores-Rojas, P. Martín-Borreguero, M. Gil-Campos. Metabolic profiling in children with autism spectrum disorder with and without mental regression: preliminary results from a cross-sectional case–control study. Metabolomics. 2019; 15 (7):99.

Chicago/Turabian Style

O. D. Rangel-Huerta; A. Gomez-Fernández; M. J. De La Torre-Aguilar; A. Gil; J. L. Perez-Navero; K. Flores-Rojas; P. Martín-Borreguero; M. Gil-Campos. 2019. "Metabolic profiling in children with autism spectrum disorder with and without mental regression: preliminary results from a cross-sectional case–control study." Metabolomics 15, no. 7: 99.

Journal article
Published: 14 June 2019 in Nutrients
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Angiopoietin-like protein 4 (ANGPTL-4) regulates lipidic metabolism and affects energy homeostasis. However, its function in children with obesity remains unknown. We investigated plasma ANGPTL-4 levels in children and its relationship with body mass index (BMI) and different lipidic parameters such as free fatty acids (FFA). Plasma ANGPTL-4 levels were analyzed in two different cohorts. In the first cohort (n = 150, age 3-17 years), which included children with normal weight or obesity, we performed a cross-sectional study. In the second cohort, which included only children with obesity (n = 20, age 5-18 years) followed up for two years after an intervention for weight loss, in which we performed a longitudinal study measuring ANGPTL-4 before and after BMI-loss. In the cross-sectional study, circulating ANGPTL-4 levels were lower in children with obesity than in those with normal weight. Moreover, ANGPTL-4 presented a negative correlation with BMI, waist circumference, weight, insulin, homeostasis model assessment of insulin resistance index (HOMA index), triglycerides, and leptin, and a positive correlation with FFA and vitamin-D. In the longitudinal study, the percent change in plasma ANGPTL-4 was correlated with the percent change in FFA, total-cholesterol and high-density lipoprotein cholesterol. This study reveals a significant association of ANGPTL-4 with pediatric obesity and plasma lipid profile.

ACS Style

Silvia Barja-Fernández; Cintia Folgueira; Cecilia Castelao; Verónica Pena-León; Patricia González-Saenz; Rocío Vázquez-Cobela; Concepción M. Aguilera; Mercedes Gil-Campos; Gloria Bueno; Ángel Gil; Luis A. Moreno; Manuel Ruiz-Piñon; María García-Palacios; Felipe F. Casanueva; Carlos Diéguez; Rubén Nogueiras; Rosaura Leis; Luisa M. Seoane. ANGPTL-4 is Associated with Obesity and Lipid Profile in Children and Adolescents. Nutrients 2019, 11, 1340 .

AMA Style

Silvia Barja-Fernández, Cintia Folgueira, Cecilia Castelao, Verónica Pena-León, Patricia González-Saenz, Rocío Vázquez-Cobela, Concepción M. Aguilera, Mercedes Gil-Campos, Gloria Bueno, Ángel Gil, Luis A. Moreno, Manuel Ruiz-Piñon, María García-Palacios, Felipe F. Casanueva, Carlos Diéguez, Rubén Nogueiras, Rosaura Leis, Luisa M. Seoane. ANGPTL-4 is Associated with Obesity and Lipid Profile in Children and Adolescents. Nutrients. 2019; 11 (6):1340.

Chicago/Turabian Style

Silvia Barja-Fernández; Cintia Folgueira; Cecilia Castelao; Verónica Pena-León; Patricia González-Saenz; Rocío Vázquez-Cobela; Concepción M. Aguilera; Mercedes Gil-Campos; Gloria Bueno; Ángel Gil; Luis A. Moreno; Manuel Ruiz-Piñon; María García-Palacios; Felipe F. Casanueva; Carlos Diéguez; Rubén Nogueiras; Rosaura Leis; Luisa M. Seoane. 2019. "ANGPTL-4 is Associated with Obesity and Lipid Profile in Children and Adolescents." Nutrients 11, no. 6: 1340.

Correspondence
Published: 18 May 2019 in Anales de Pediatría
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Eva María Tejada-Ortigosa; Katherine Flores-Rojas; Laura Moreno-Quintana; Mercedes Gil-Campos. Perspectiva de género sobre los cuidados informales de las niñas y niños con enfermedades raras. Anales de Pediatría 2019, 91, 282 .

AMA Style

Eva María Tejada-Ortigosa, Katherine Flores-Rojas, Laura Moreno-Quintana, Mercedes Gil-Campos. Perspectiva de género sobre los cuidados informales de las niñas y niños con enfermedades raras. Anales de Pediatría. 2019; 91 (4):282.

Chicago/Turabian Style

Eva María Tejada-Ortigosa; Katherine Flores-Rojas; Laura Moreno-Quintana; Mercedes Gil-Campos. 2019. "Perspectiva de género sobre los cuidados informales de las niñas y niños con enfermedades raras." Anales de Pediatría 91, no. 4: 282.