Glioblastomas (GBM) are the most common primary brain tumor with a median survival of 15 months. A population of cells with stem cell properties (glioblastoma stem cells, GSCs) drives the initiation and progression of GBM and is localized in specialized microenvironments which support their behavior. GBM are characterized as extremely resistant to therapy, resulting in tumor recurrence. Reactive oxygen species (ROS) control the cellular stability by influencing different signaling pathways. Normally, redox systems prevent cell oxidative damage; however, in gliomagenesis, the cellular redox mechanisms are highly impaired. Herein we review the dual nature of the redox status in drug resistance. ROS generation in tumor cells affects the cell cycle and is involved in tumor progression and drug resistance in GBM. However, excess ROS production has been found to induce cell death programs such as apoptosis and autophagy. Since GBM cells have a high metabolic rate and produce high levels of ROS, metabolic adaptation in these cells plays an essential role in resistance to oxidative stress-induced cell death. Finally, the microenvironment with the stromal components participates in the enhancement of the oxidative stress to promote tumor progression and drug resistance.

Energy efficiency and low-carbon energy systems are increasingly taken into account in seaports, due to climate change challenges and the evolution of environmental regulations. Thus, technological breakthroughs must be brought to numerous systems in harbors, such as harbor cranes, seaport vehicles, or the power supply of berthed vessels. These aspects may require the establishment of a microgrid in the harbor area. Microgrids have been subjected to a wide development on the mainland and islands, mostly for domestic loads. However, these are still scarce in harbor areas. Their development in such places faces several challenges, such as high power requirements, monitoring and management of a wide range of loads, energy policy framework, etc. Moreover, the establishment of a microgrid involves a study of sizing and of energy management, to avoid prohibitive costs and to verify load requirements. This paper provides a literature survey related to the development of microgrids in seaport areas. Firstly, the main components that occur in harbor microgrids are listed, and then a review of studies dealing with sizing and energy management is proposed. Finally, from this survey, innovative concepts and barriers are listed, with an up-to-date review of microgrid development in seaports worldwide.

This paper proposes a simple and effective method to reduce speed ripples of Permanent Magnet Synchronous Machines (PMSMs) at low speed working conditions. The treated issue is related to the periodic torque ripples which induce speed oscillations that deteriorate the drive performance. The main idea of the proposed method is to modify a conventional PMSM controller by superposing an appropriate compensation signal to the quadratic-current reference. The proposed approach allows to reduce speed ripples at low speed through a simple compensation signal and does not require a hard calculation cost. A theoretical analysis is presented, and both simulation and experimental results are presented to validate the proposed compensation method.

Proton Exchange Membrane (PEM) water electrolysers have gained attention as efficient and sustainable hydrogen production devices. Understanding their electrical behavior is crucial for optimizing their performance and control strategies. This comprehensive review analyzes both the static and dynamic electrical models, emphasizing the often-neglected dynamic models. Static models reveal steady-state behavior, offering insights into voltage-current characteristics, polarization phenomena, and overall efficiency. On the other hand, dynamic models capture transient responses, enabling an analysis of time-dependent performance and system reactions to input variations, such as flow rate, temperature, pressure, and electrical potential. The review also addresses overlooked diffusion phenomena, crucial for accurate mass transport dynamics and enhancing dynamic model accuracy. Furthermore, the article highlights challenges and research possibilities in electrical modeling, offering insight into future research subjects.

NSAIDs exhibit protective properties towards some cancers, especially colon cancer. Yet, it is not clear how they play their protective role. PGE2 is generally shown as the only target of the NSAIDs anticancerous activity. However, PGE2 known targets become more and more manifold, considering both the molecular pathways involved and the target cells in the tumour. The role of PGE2 in tumour progression thus appears complex and multipurpose.