Achieving the UN Sustainable Development Goals depends on using resources efficiently, avoiding fragmentation in decision-making, recognising the trade-offs and synergies across sectors and adopting an integrated Nexus thinking among policymakers. Nexus Informatics develops the science of recognising and quantifying nexus interlinkages. Nexus-coherent solutions enhance the effect of policymaking in achieving adequate governance, leading to successful strategic vision and efficient resource management. In this article, we present the structure of a System Dynamics Model-the Nexus_SDM-that maps sector-specific data from major databases (e.g., EUROSTAT) and scenario models (e.g., E3ME-FTT OSeMOSYS and SWIM) for the national case study of Greece. Disaggregation algorithms are employed on annual national-scale data, turning them into detailed spatial and temporal datasets, by converting them to monthly values spread among all 14 River Basin Districts (RBDs). The Nexus_SDM calculates Nexus Interlinkage Factors and quantifies interlinkages among Water, Energy, Food, Built Environment, Natural Land and greenhouse gas (GHG) emissions. It simulates the nexus in the national case study of Greece as a holistic multi-sectoral system and provides insights into the vulnerability of resources to future socio-economic scenarios. It calculates the link between crop type/area, irrigation water and agricultural value, revealing which crops have the highest agricultural value with the least water and crop area. It demonstrates that fossil fuel power generation and use of oil for transportation are responsible for the most GHG emissions in most RBDs and presents projections for years 2030 and 2050. The analysis showcases that to move from a general nexus thinking to an operational nexus concept, it is important to focus on data availability and scale. Advanced Sankey and Chord diagrams are introduced to show distribution of resource use among RBDs and an innovative visualisation tool is developed, the Nexus Directional Chord plot, which reveals Nexus hotspots and strong interlinkages among sectors, facilitating stakeholder awareness.

Water, energy, food, land and climate form a tightly-connected nexus in which actions on one sector impact other sectors, creating feedbacks and unanticipated consequences. This is especially because at present, much scientific research and many policies are constrained to single discipline/sector silos that are often not interacting (e.g., water-related research/policy). However, experimenting with the interaction and determining how a change in one sector could impact another may require unreasonable time frames, be very difficult in practice and may be potentially dangerous, triggering any one of a number of unanticipated side-effects. Current modelling often neglects knowledge from practice. Therefore, a safe environment is required to test the potential cross-sectoral implications of policy decisions in one sector on other sectors. Serious games offer such an environment by creating realistic ‘simulations’, where long-term impacts of policies may be tested and rated. This paper describes how the ongoing (2016–2020) Horizon2020 project SIM4NEXUS will develop serious games investigating potential plausible cross-nexus implications and synergies due to policy interventions for 12 multi-scale case studies ranging from regional to global. What sets these games apart is that stakeholders and partners are involved in all aspects of the modelling definition and process, from case study conceptualisation, quantitative model development including the implementation and validation of each serious game. Learning from playing a serious game is justified by adopting a proof-of-concept for a specific regional case study in Sardinia (Italy). The value of multi-stakeholder involvement is demonstrated, and critical lessons learned for serious game development in general are presented.