The work environment plays a crucial role in the health and performance of employees. The growing interest in workers’ well-being has driven the inclusion of nature in workplaces, despite many employees spending most of their time indoors, away from nature. Studies show that biophilic design in offices can have positive effects and promote workers’ well-being. However, research on the beneficial effects of nature exposure in the workplace is limited and scattered. Thus, the aim of this systematic review was to consolidate current knowledge on the restorative effects of nature exposure on workers during work activities. Different types of exposure, both outdoors and indoors, were considered, with a focus on outcomes related to well-being, motivation, job satisfaction, and work performance. Out of the initially identified 1225 articles, only 16 met the criteria for analysis. Although the analysed studies provided compelling evidence regarding the restorative effects of nature exposure in the workplace, the review also points out gaps and limitations concerning the number of specific studies in this area and the need to adequately assess the sensory dimensions involved in these effects. Conducting more comprehensive and multidimensional investigations into the impacts of nature on the work environment could contribute to guiding more effective design strategies and creating healthier and more productive workplaces for employees.