Large interindividual variations in the biological response to citrus flavanones have been observed, and this could be associated with high variations in their bioavailability. The aim of this study was to identify the main determinants underlying interindividual differences in citrus flavanone metabolism and excretion. In a randomized cross-over study, non-obese and obese volunteers, aged 19–40 years, ingested single doses of Pera and Moro orange juices, and urine was collected for 24 h. A large difference in the recovery of the urinary flavanone phase II metabolites was observed, with hesperetin-sulfate and hesperetin-sulfo-O-glucuronide being the major metabolites. Subjects were stratified according to their total excretion of flavanone metabolites as high, medium, and low excretors, but the expected correlation with the microbiome was not observed at the genus level. A second stratification was proposed according to phase II flavanone metabolism, whereby participants were divided into two excretion groups: Profiles A and B. Profile B individuals showed greater biotransformation of hesperetin-sulfate to hesperetin-sulfo-O-glucuronide, as well as transformation of flavanone-monoglucuronide to the respective diglucuronides, suggestive of an influence of polymorphisms on UDP-glucuronosyltransferase. In conclusion, this study proposes a new stratification of volunteers based on their metabolic profiles. Gut microbiota composition and polymorphisms of phase II enzymes may be related to the interindividual variability of metabolism.

Citrus fruits and juices are a major source of dietary flavanones, and the regular consumption of these foods is inversely associated with the development of cardiometabolic diseases. However, the biological benefits depend on the bioavailability of these compounds, and previous studies have reported a large interindividual variability in the absorption and excretion of these compounds. Different factors, such as age, gender or genetic polymorphism of genes coding enzymes involved in the metabolism and transport of the flavanones, may explain this heterogeneity. This study aimed to assess the impact of single nucleotide polymorphism of sulfotransferases SULT1A1 and SULT1C4, and ABCC2 transporter genes on excretion of phase II flavanone metabolites in volunteers after 24 h of orange juice intake. Forty-six volunteers ingested a single dose of 500 mL of orange juice and 24-h urine was collected. The hesperetin and naringenin phase II metabolites were quantified in urine, and SNPs in SULT1A1, SULT1C4 and ABCC2 genes were genotyped. A significant (p < 0.05) relationship between the SNPs in these genes and the high excretion of phase II flavanone metabolites were observed. These results identified novel polymorphisms associated with higher absorption of flavanones, which may provide bases for future personalized nutritional guidelines for consuming flavanone-rich foods rich in these nutrients for better benefit from their health properties.

No âmbito das Unidades de Alimentação e Nutrição Hospitalares (UANSs) há produção de resíduos que são descartados durante a produção de refeições. Foi realizado um estudo transversal para levantamento das práticas de sustentabilidade de quatorze UANs hospitalares capital brasileira situa na região Nordeste. Para tanto foi aplicado um questionário digital aos nutricionistas responsáveis pelas UANs, que abordou aspectos sobre gestão, controle no consumo de água, energia, prática de coleta seletiva de resíduos, descarte de óleos e gorduras, oferta de alimentos regionais com aquisição proveniente da agricultara familiar. Foi realizada análise estatística descritiva e calculadas as frequências simples e relativas, com auxílio do software Microsoft Excel, versão 2013. As unidades adotam algumas práticas sustentáveis, em relação ao planejamento e elaboração do cardápio respeitando a sazonalidade dos alimentos, assim como a utilização de alimentos regionais. Contudo outras questões consideradas relevantes como as constantes capacitações dos funcionários, coleta seletiva, entre outras ainda não são realizadas nestas unidades. Diante da avaliação, observou-se que as unidades apresentam aspectos favoráveis à sustentabilidade ambiental, no entanto também foram identificadas práticas inadequadas à manutenção do ambiente, assim torna-se imprescindível a reformulação das condutas nesses locais visando à minimização dos impactos ambientais.

Talisia esculenta (A. ST.-HIL.) Radlk is a Brazilian wild fruit, known as a pitomba, belonging to the Sapindaceae family. The objective of the present work was to perform a review of the literature in order to identify studies on its physico-chemical characterization, antioxidant activity and biological activity. The articles search was done in PubMed, SciELO, Science Direct and LILACS. We identified 90 publications, 8 in SciELO, 3 in LILACS, 67 in Science Direct and 12 in PubMed. Subsequently, duplication of the articles between the databases was verified, and the triage was done by reading the titles, abstracts and reading in full, to analyze which articles fit the study objective, and only 5 studies were included. The review exposes Talisia esculenta Radlk (A. ST.-HIL.) as a fruit that has a bioactive potential, but there is a shortage of studies that deal with its chemical composition and its biological activity.